@XR_Lab profile picture
Xiaojun Ren Group at UNC Charlotte @XR_Lab

My lab aims to understand the fundamental principles of genome regulation. We are particularly interested in LLPS and single molecules.

Joined December 2016
  • Tweets 468
  • Following 474
  • Followers 468
22 Photos and videos
ErbB family receptor dimerization dynamics and dysregulation via long-term single-molecule imaging: Cell cell.com/cell/fulltext/S0092…

ErbB family receptor dimerization dynamics and dysregulation via long-term single-molecule imaging

Ma et al. developed long-term single-particle tracking of ErbB family receptors in living cells using upconverting nanoparticles. They discovered constitutive HER2 and HER3 homodimerization and...

cell.com
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Xiaojun Ren Group at UNC Charlotte retweeted
UNC Biochemistry and Biophysics department@UNC_BCBP
Apr 17
“Spatial Organization of Epigenetic Information by Phase Separation” presented by Xiaojun (XJ) Ren, Ph.D. on Tuesday, April 21, 2026 – 11:00 am – 12:00 pm 1131 Bioinformatics Host: Jill Dowen Join us for our last seminar of the Spring semester.
“Spatial Organization of Epigenetic Information by Phase Separation” presented by Xiaojun (XJ) Ren, Ph.D. on Tuesday, April 21, 2026 – 11:00 am – 12:00 pm 1131 Bioinformatics Host: Jill Dowen Join us for our last seminar of the Spring semester.

ALT “Spatial Organization of Epigenetic Information by Phase Separation” presented by Xiaojun (XJ) Ren, Ph.D. on Tuesday, April 21, 2026 – 11:00 am – 12:00 pm 1131 Bioinformatics Host: Jill Dowen Join us for our last seminar of the Spring semester.

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It is so nice to see our Molecular Cell paper is out today! Thanks for my students and collaborators. Without you, this is impossible. Thanks for all reviewers! Your constructive comments make the paper much better!!!
Molecular Cell@MolecularCell
Mar 4
Online Now: Self-clustering of three CBX2 molecules drives PRC2 to promote facultative heterochromatinization of Polycomb target genes dlvr.it/TRHn4K
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Xiaojun Ren Group at UNC Charlotte retweeted
Andy Truman PhD@TrumanLab
Feb 26
New article about our research: science.charlotte.edu/2026/0…

UNC Charlotte Truman Lab publishes new insights into cellular heat shock response in Nature...

A new study from the Truman Lab has been published in Nature Communications, offering a deeper understanding of how cells respond to heat-induced stress.

science.charlotte.edu
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Xiaojun Ren Group at UNC Charlotte retweeted
Molecular Cell@MolecularCell
5 Dec 2025
Transcriptome-wide mRNP condensation precedes stress granule formation and excludes new mRNAs dlvr.it/TPffCB
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Multiscale structure of chromatin condensates explains phase separation and material properties | Science science.org/doi/10.1126/scie…

Multiscale structure of chromatin condensates explains phase separation and material properties

The structure and interaction networks of molecules within biomolecular condensates are poorly understood. Using cryo–electron tomography and molecular dynamics simulations, we elucidated the...

science.org
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Xiaojun Ren Group at UNC Charlotte retweeted
Huaiying Zhang@lab_zhang
3 Sep 2025
Happy to see this coming out at JCB!
Journal of Cell Biology@JCellBiol
3 Sep 2025
Rongwei Zhao et al. @lab_zhang @CarnegieMellon show that, in #cancer cells using the alternative lengthening of telomeres (ALT) pathway, #SUMO levels at #telomeres influence the formation of ALT-associated PML bodies. hubs.la/Q03GK3qh0
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Excited to have this powerful single-molecule microscopy installed. Exciting discoveries will come soon……
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We are pleased to announce the Inaugural 2025 Carolina Symposium on Genome Integrity and Chromatin Regulation on June 11, 2025 @unccharlotte Free registration, abstract for talk/poster: biology.charlotte.edu/announ…
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Cryo-EM reveals mechanisms of natural RNA multivalency | Science science.org/doi/10.1126/scie…

Cryo-EM reveals mechanisms of natural RNA multivalency

Homo-oligomerization of biological macromolecules leads to functional assemblies that are critical to understanding various cellular processes. However, RNA quaternary structures have rarely been...

science.org
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Xiaojun Ren Group at UNC Charlotte retweeted
Ning Zhao@NingInScience
18 Feb 2025
Imaging single endogenous RNA in live cells comes true!
Nature Biotechnology
@NatureBiotech
18 Feb 2025
Single-molecule live-cell RNA imaging with CRISPR–Csm go.nature.com/3EJPKsM
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Xiaojun Ren Group at UNC Charlotte retweeted
Robert Aboukhalil@RobAboukhalil
9 Aug 2021
Really excited to unveil sandbox.bio, an interactive playground for learning bioinformatics command-line tools like bedtools, bowtie2, and samtools (and more to come!) 🧑‍💻 🧬 Thanks to @aaronquinlan, @BenLangmead, and @mike_schatz for feedback and tutorial ideas.
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My lab is looking for a postdoctoral fellow. Exciting opportunities for LLPS, single-molecule imaging, genomic approaches, and genetic engineering. Pls RT
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ShorterLab@ShorterLab
6 Nov 2024
Threonine-rich carboxyl-terminal extension drives aggregation of stalled polypeptides: Molecular Cell cell.com/molecular-cell/full…

Threonine-rich carboxyl-terminal extension drives aggregation of stalled polypeptides

When ribosomes stall during translation of defective mRNAs, the resulting incomplete polypeptides form detergent-insoluble aggregates. Chang & Yoon et al. demonstrate that threonine residues drive...

cell.com
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As a new faculty member at UNC Charlotte, I am excited to present my first seminar here. ⁦@ShanYanLab⁩ Thanks for the picture!
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Xiaojun Ren Group at UNC Charlotte retweeted
Ben Sabari@bsabari
20 Sep 2024
Excited to share that our paper cell.com/molecular-cell/full… got the cover of the new issue of @MolecularCell. Extra cool that this is a photograph taken by the first author @Nancybrillet, a super-star research assistant and post-bacc who just started grad school @UTSWGradSchool
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Tjian Darzacq Group
@TjianDarzacq
13 Sep 2024
So cool to see @tgwgraham’s work featured in the @Nature Briefing today! Read more about our developments to detect single molecule protein-protein interactions in live cells here : nature.com/articles/d41586-0…

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Xiaojun Ren Group at UNC Charlotte retweeted
Jane Skok@jane_skok
11 Sep 2024
Registration for the 5th Annual Meeting on Advances in Nuclear Topology & 3D Chromatin Architecture in Cancer is NOW OPEN! Get ready to hear from an all-star lineup of speakers – you won't want to miss this. Register for free: bit.ly/chromatin-2024 #chromatin2024
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🚀 My lab is recruiting technicians, PhD students, and postdocs! Join us to leverage single-molecule techniques, genomic approaches, and genetic engineering to explore the roles of LLPS in genome regulation. Exciting opportunities to contribute to cutting-edge research!
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🚀 Thrilled to announce my lab has moved to UNC Charlotte, a vibrant and rapidly growing university! Huge thanks to my colleagues, collaborators, and friends for their support over the years. Excited for this new chapter and the great science ahead! 🌟🔬
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