PostDoc working on sarcoma genomics and biology at UCL Cancer Institute, with a special interest in genomically complex tumours.
Joined January 2017
- Tweets 61
- Following 76
- Followers 155
- Likes 78
3 Photos and videos
Christopher Steele retweeted
15 Nov 2022
Proud and excited to receive a @DFF_raad grant for the startup of my translational renal cancer research group at @moma_dk #renalcancer
15 Nov 2022
28 lovende, yngre forskere har netop modtaget bevillinger for 78 millioner kroner under Inge Lehmann-programmet, der har til formål at fremme mere ligestilling i forskningsmiljøer i Danmark. #dkforsk
Læs mere og se projekterne her👇
dff.dk/aktuelt/nyheder/28-fo…
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Christopher Steele retweeted
14 Oct 2022
Thrilled to share our latest paper on #mutationalsignatures recently published in @CellGenomics 🙌 Thanks so much to everyone that made SigProfilerExtractor a reality, especially Ludmil, @mishugeb, Mark and @VangaraRaviteja.
Check it out here: doi.org/10.1016/j.xgen.2022.…
13 Oct 2022
1/3 New powerful #AI, produced by #CancerGrandChallenges researchers and published in @CellGenomics, identifies 4 new #mutationalsignatures – including the long-sought-after link between #tobacco and #bladdercancer. Find out more: tinyurl.com/48svmp83
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Christopher Steele retweeted
14 Oct 2022
*Communication is everything*
In our latest work we found that histone-H3.3 mutation in the #bone dysregulates the communication between osteoclasts and osteoblasts driving giant cell #tumour of the bone.
#celldeathdifferentiation @cddpress
nature.com/articles/s41418-0…
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16 Jun 2022
I could not have done this without a @CRUKresearch travel grant, nor without the support of @NischalanP to pursue this line of research, or Ludmil Alexandrov for seeing the potential in the method! 2/2
nature.com/articles/s41586-0…
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16 Jun 2022
We have expanded our previous method of copy number signatures developed in sarcomas to identify a reference set of pan-cancer copy number signatures. These are available on @cosmic_sanger
now! 1/2
nature.com/articles/s41586-0…
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Christopher Steele retweeted
31 May 2022
Topographies of more than 70 mutational signatures are now available on COSMIC mutational signatures database.
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Christopher Steele retweeted
17 May 2022
Super excited to share our opinion article @IMalanchi and @fcicca from @TheCrick on @TrendsCellBio. We aim to add a new perspective to cancer initiation by asking two simple questions: 1) How does a mutant cell gain tumorigenic potential? cell.com/trends/cell-biology…
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Christopher Steele retweeted
19 Apr 2022
Our paper on #ctDNA in #osteosarcoma is out in European Journal of Cancer. Supported by @TomPrinceCT, @BCRT, @lundbeckfonden.
Great collaboration with @NeeshaKara, Adrienne Flanagan, Solange De Noon, @StephanBeck6, @iusher3, @orthopoda and others.
sciencedirect.com/science/ar…
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Christopher Steele retweeted
19 Mar 2020
If you are a data scientist (or just good at coding, machine learning, maths and stats) this is your chance to contribute to #COVID19 critical care! Help doctors find out what they can do to help maximise the survival rate of ICU patients? #datasaveslives
19 Mar 2020
This is open to everyone (not just UCL people)
Pls RT: @rco_slms_ucl @ucl_slms @UCLPopHealthSci @UCL_IHI @ICodingclub @uclmedsci @icls_info @CLOSER_UK @uclmaps @uclcs @UCL_ICS @UCL_Energy @IEHC_ECF @UCL_IEHC @gianlubaio @MathematicsUCL @UCL_BEAMS_SRF @UCLmedphys @Health_Eng
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12 Mar 2020
If you are interested in rare and fascinating cancers check out our review of the current knowledge of #undifferentiatedsarcoma of soft tissue. Come for shattered chromosomes, near-haploidy, hypermutation and extensive genome doubling! #TheLoneliestCancer authors.elsevier.com/c/1aj5-…
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Christopher Steele retweeted
25 Mar 2019
New paper out today in the Annals of Human Genetics from @UGI_at_UCL Professor @davecurtis314 "Clinical relevance of genome‐wide polygenic score may be less than claimed" tinyurl.com/y6zz97pu #ugi #ucl #polygenic #PRS
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18 Mar 2019
Our research on undifferentiated sarcoma is out today! Have a read to learn more about the genomics underlying this rare tumour type, including highly complex structural rearrangements, hypermutation, near-genome scale haploidy and more! authors.elsevier.com/sd/arti…
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Christopher Steele retweeted
1 Oct 2018
BREAKING NEWS
The 2018 #NobelPrize in Physiology or Medicine has been awarded jointly to James P. Allison and Tasuku Honjo “for their discovery of cancer therapy by inhibition of negative immune regulation.”
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Christopher Steele retweeted
15 Sep 2018
Cancer Spreads from Organ Donor to 4 People in 'Extraordinary' Case goo.gl/NJaJNt
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Christopher Steele retweeted
5 Sep 2018
In this review from the Balloux lab and friends @Vehuardo @kathrynharris26 we identify major bottlenecks that need to be resolved for WGS to routinely inform clinical intervention and discuss possible solutions. tinyurl.com/y9n25x8s #wgs #diagnostics #amr
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Christopher Steele retweeted
4 Jul 2018
TRACERx Bioinformatics positions available to work on lung cancer evolution and the immune microenvironment in our lab @TheCrick please retweet or apply (or both!) atsv7.wcn.co.uk/search_engin…
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Christopher Steele retweeted
2 May 2018
New package bioconductor.org/packages/TC… by @M2RUseR provides a suite of helper functions for checking and manipulating TCGA data including data obtained from the curatedTCGAData experiment package.
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Christopher Steele retweeted
2 May 2018
New package bioconductor.org/packages/cu… provides unrestricted TCGA assays and merged clinical/pathological/specimen data as MultiAssayExperiments containing SummarizedExperiment and RaggedExperiment objects, through ExperimentHub.
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Christopher Steele retweeted
25 Apr 2018
#TRACERx Renal: Preview of how 3 multi-center prospective studies 2 validation cohorts of matched primary metastasis biopsies fm 100 patients with clear-cell renal cell carcinoma provides a comprehensive picture of genetics & evolution of #metastasis bit.ly/2FhcxHR
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