From @davisjmcc, @YuanhuaHuang, @OliverStegle and Teichmann lab: Cardelino leverages variant information from single-cell RNA-seq data for inferring clonal tree configuration and mapping cells to their clone of origin. nature.com/articles/s41592-0…
For the first time, the highly dynamic cellular landscape of the human thymus has been charted across a lifespan, according to a new Science report, which may be useful in developing future T-cell therapeutic strategies. ($) fcld.ly/kc9mg52
Our work on T-cell lineage commitment and TCR recombination in the native thymic microenvironment across human lifespan is online! Fantastic team led by @park_jongeun, Sarah Teichmann, @Muzz_Haniffa and @taghon_t
science.sciencemag.org/conte…
Cardelino: Integrating whole exomes and single-cell transcriptomes to reveal phenotypic impact of somatic variants biorxiv.org/cgi/content/shor…#bioRxiv
Fast Batch Alignment of Single Cell Transcriptomes Unifies Multiple Mouse Cell Atlases into an Integrated Landscape biorxiv.org/cgi/content/shor…#bioRxiv
How can single-cell methodologies unravel immune cell fates?Check this mini review by @danieljkunz , me and @KylieReneeJames to learn about cell fate tracking, trajectories and more! @FrontImmunolfrontiersin.org/articles/10.…
Interested in new insights into alternative splicing at the single-cell level and how DNA methylation plays a so far underappreciated role? Take a look at our new bioRxiv preprint: biorxiv.org/content/early/20… Great collaboration with @mjbonder@OliverStegle @davisjmcc @StatGenomics
Our methods (with @OliverStegle ) do detect spatially variable genes and perform expression based histology are now published in Nature Methods! nature.com/articles/nmeth.46…
Our manuscript is now out in Nature Physics: Universal scaling behaviour of clone dynamics during tissue growth. Highlights emergence of core concepts of statistical physics in an unexpected context and implications for stem cell biology. nature.com/articles/s41567-0…
We have updated our SpatialDE paper - biorxiv.org/content/early/20…, largest addition is "automatic expression histology" which finds patterns defined by co-expressing genes with a GP mixture model.