(1/12) Over a year ago, we launched a new project to explore whether the tissue microenvironment could predict cellular behaviour and whether reprogramming might unlock new therapeutic avenues. 🧬 Spatial transcriptomics provides deep insights into tissue organisation. We wanted to take this further by building a model that predicts how the tissue microenvironment rewires cells, and in silico predict how reprogramming influences the diseased microenvironment. Today, in collaboration with @Muzz_Haniffa at @sangerinstitute we’re excited to share the preprint for Mintflow, including two novel disease datasets. Link to preprint: shorturl.at/alFUO 🧵

📢 Excited to share our new study, "Spatiotemporal Single-Cell Roadmap of Human Skin Wound Healing," in Cell Stem Cell! sciencedirect.com/science/ar… 🧵

These @humancellatlas papers are a major milestone. We’re proud to be among the funders of the Human Cell Atlas. This project, which has built a vibrant global community to work openly and in partnership, represents discovery science at its best.

“The @humancellatlas was one of @ChanZuckerberg’s first big bets in science, & these landmark papers are a testament to the power of collaboration.” –Steve Quake, Head of Science

Out today in Nature: "The Human Cell Atlas"! In my commentary, I compare the cell atlas to early naturalists exploring South America. Researchers mining this cell atlas can now make big discoveries, just as the next naturalists then discovered evolution. nature.com/articles/d41586-0…

🚨 New publication alert! 🚨 As part of the exciting #HCA publication bundle in @Nature, we reveal metaplasia’s role in inflammation in gut diseases, powered by a single-cell atlas of the entire human gastrointestinal tract. 🌟 nature.com/articles/s41586-0…

⭐️NEW PAPER OUT in @Nature⭐️ 🫀What is the relationship between the immune responses in the heart, blood, and tumor in patients with inflammation in the heart resulting from cancer immunotherapy (irMyocarditis)? This 🧵 breaks down the key findings 1/n nature.com/articles/s41586-0…

Cutaneous T cell lymphoma atlas reveals malignant TH2 cells supported by a B cell-rich tumor microenvironment @NatImmunol @Muzz_Haniffa @teichlab @RuoyanLi nature.com/articles/s41590-0…

Thrilled to share our recent work on cutaneous T cell lymphoma. Check it out. ⁦@NatImmunol⁩ ⁦@teichlab⁩ ⁦@HaniffaLab⁩ nature.com/articles/s41590-0…

New, highly requested, guidance from us @wellcometrust on how to discuss Research Environment in your application, and the kinds of things you might want to tell us about! wellcome.org/what-we-do/our-…

New Review from @Muzz_Haniffa and colleagues @sangerinstitute explains how the prenatal immune system develops rdcu.be/dZcJn

‘We are poised for an exciting era of translational ageing research with opportunities to build an interdisciplinary clinical and academic community’. Professor @AvanSayer presented the 2024 #HarveianOration, which you can now watch on demand: ow.ly/F85O50U0aBY

Really enjoyed writing this review @NatRevImmunol on our current understanding of the human prenatal immune system. Full text access: rdcu.be/dYJWg

Immune cells drive development of vessels in the skin 📹 still: Nusayhah Hudaa Gopee, Elena Winheim, @BayanneOlabi et al @Muzz_Haniffa @nubiosciences @krkoehler @BostonChildrens @teichlab @sangerinstitute in @Nature ➡️: bpod.org.uk/archive/2024/10/…

We're also hiring a Research Software Developer. Join us to redesign @omnipathdb and work with Postgres, Python, TypeScript & more) in systems biomedicine. PhD or relevant experience in engineering, CS, or computational bio required. Apply by Nov 18, 2024. tinyurl.com/mwjm56xk

Thank you @NatRevImmunol for highlighting the role of macrophages in human development - in the pancreas by @mcnostro @MCNostroLab and our study on human skin

Immune cells guide and protect developing skin, much like keystone species in a rainforest. @HaniffaLab @Muzz_Haniffa @teichlab @krkoehler @humancellatlas @EdelOToole @TreutleinLab @bayraktar_lab @FranzeProgatzky @UniofNewcastle @sangerinstitute nature.com/articles/s41586-0…

Ready for #DC2024Barcelona? We have ahead of us 4 fascinating days to share new data & discussions and to boost basic & translational research on #dendriticcells 25 top🌍speakers, 46 short talks, 200 posters, >300 attendees! support by @SEinmunologia @SCImmunologia @EuMacDcSoc

Only half day left #esid2024, but what a great agenda: @Muzz_Haniffa - queen of single cell immunology @BrodinPetter - king of systems immunology @123456789Dusan - master of human immunogenetics Followed by some amazing late breaking abstracts!

Great interview with Helen Berman 👇🏾