@fcylee profile picture
Flora Lee @fcylee
Joined February 2014
  • Tweets 202
  • Following 158
  • Followers 163
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Flora Lee@fcylee
1 Mar 2023
It was a special day to finally meet everyone at the Centre! I look forward to starting more interdisciplinary RNA neurodev research with my sponsors and collaborators!
CDN | King's College@dev_neuro
1 Mar 2023
Congratulations Flora Lee on being awarded a 5 year @wellcometrust Early Career Award! Today is her first day at the CDN. She will be working with @L_andreae looking at synaptic mRNA dysregulation in neurodevelopmental disorders.
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Boris Lenhard@BorisLenhard
7 Nov 2024
Our paper on the origin and properties of elusive 3' UTR-derived capped mRNA fragments is out. Great work by @NejcHaberman in collaboration with @AidaMartinezS, @TheSibleyLab, @GroupLenhard . link.springer.com/article/10…

Widespread 3′UTR capped RNAs derive from G-rich regions in proximity to AGO2 binding sites

BMC Biology - The 3′ untranslated region (3′UTR) plays a crucial role in determining mRNA stability, localisation, translation and degradation. Cap analysis of gene expression (CAGE), a...

link.springer.com
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Malgorzata Rogalska@MalgorzataRoga1
31 Oct 2024
🎉Excited to announce that our paper on the blueprint of the human spliceosome is now out in @ScienceMagazine ! A decade of work with Juan Valcárcel and the incredible team at @CRGenomica to uncover the intricate roles of this essential RNA machinery.science.org/doi/10.1126/scie…

Transcriptome-wide splicing network reveals specialized regulatory functions of the core spliceosome

The spliceosome is the complex molecular machinery that sequentially assembles on eukaryotic messenger RNA precursors to remove introns (pre-mRNA splicing), a physiologically regulated process...

science.org
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Shannon Rhoads@ShanRhoads
31 Oct 2024
Check out our preprint using imaging-omics to characterize the #OrganelleSignature - the morphology interactions & distribution of #ER❤️ #Lysosomes🩵 #Mitochondria💚 #Peroxisomes🧡 #Golgi💛 & #LipidDroplets🩷 - of live #neurons and #astrocytes! doi.org/10.1101/2024.10.30.6… 🧵1/11

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Vijay Ganesh@VGaneshMDPhD
24 Oct 2024
Excited to report our study in @NEJM on the discovery of deletions in a long noncoding RNA gene 🧬 (𝘊𝘏𝘈𝘚𝘌𝘙𝘙) as the cause of a newly defined human neurodevelopmental disorder 🧠. 🧵1/10 nejm.org/doi/full/10.1056/NE…

Neurodevelopmental Disorder Caused by Deletion of CHASERR, a lncRNA Gene | NEJM

CHASERR encodes a human long noncoding RNA (lncRNA) adjacent to CHD2, a coding gene in which de novo loss-of-function variants cause developmental and epileptic encephalopathy. Here, we report our ...

nejm.org
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Miha Modic@paraspeckle
17 Oct 2024
Thrilled to share our latest manuscript on smOOPs, a highly interconnected class of condensation-prone mRNAs with signs of coordinated regulation, encoding functionally related proteins. Shoutout to the incredible team @IraIosub, Jona & @KlobucarTajda. shorturl.at/EaSxD

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Yoseph Barash@YosephBarash
11 Oct 2024
📣 If you are interested in #RNA #Splicing using long or short #RNASeq check out our recent paper on combining and contrasting short and long reads for this genome.cshlp.org/content/ear… - we think there are some important lessons for where/how you invest time/💰 🧐and...

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Faraz K Mardakheh@FKHM
21 Sep 2024
🚨 Check out our new preprint “An intrinsically disordered RNA-binding region provides local target selectivity and is essential for LARP6 function”, out now on bioRxiv: biorxiv.org/content/10.1101/… A fun joint project with Conte’s lab @KingsCollegeLon. @QMBCI @BiochemOxford (1/10)

An intrinsically disordered RNA-binding region provides local target selectivity and is essential...

In addition to structured RNA-binding domains (RBDs), most RNA-binding proteins (RBPs) contain intrinsically disordered regions (IDRs), which are thought to possess additional RNA-binding activities....

biorxiv.org
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Richard Taylor@RNA_Richard
19 Sep 2024
Our review discussing the diversity of RNA types that localise to different parts of the neuronal periphery and the local regulation they undergo has just been published! 😃😃 @nikolas_neuro frontiersin.org/articles/10.…

Frontiers | RNA in axons, dendrites, synapses and beyond

In neurons, a diverse range of coding and non-coding RNAs localize to axons, dendrites, and synapses, where they facilitate rapid responses to local needs, s...

frontiersin.org
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Max Koppers@MaxKoppers
19 Sep 2024
We are hiring! If you are looking for a PhD position and are interested in cellular and molecular neuroscience, consider applying! @FGA_lab @VUamsterdam @ERC_Research Please share 🙏 workingat.vu.nl/vacancies/ph…
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Faraz K Mardakheh@FKHM
9 Sep 2024
Delighted to see this study on systematic identification of RBP networks out in @NatureComms! A fun collaboration between the labs of @genophoria, @halfacrocodile, and us! Massive congratulations to @khorms57 and other authors (including Martin)! 🎉 nature.com/articles/s41467-0…
https://doi.org/10.1038/s41467-024-52215-7

ALT https://doi.org/10.1038/s41467-024-52215-7

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Barna Lab@mbarnalab
7 Aug 2024
1/9 We show that Human ribosomes have different rRNA sequences, predominantly indels. These include abundant variants such as GGC indels, which form different structures. We visualize variants in single cells and associate them with development and cancer. doi.org/10.1016/j.xgen.2024.…
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Eva Kaulich@EvaKaulich
6 Aug 2024
How do different neuronal populations and compartments determine molecular and synaptic diversity? Check out our collaborative effort for parallel transcriptomic and proteomic profiling of the hippocampus! @erin_schuman Lab at @MpiBrain @biorxiv_neursci
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The Blencowe Lab @ U of T@Blencowe_Lab
30 Jul 2024
Out now: Using highly sensitive luminescence splicing reporters, we screened ~95,000 small-molecule compounds for modulators of neuronal microexons, a class of highly conserved alternative splicing misregulated in #autism & #NeuroendocrineCancer. 1/4 go.nature.com/3Wh6kp2

High-throughput sensitive screening of small molecule modulators of microexon alternative splicing...

Nature Communications - Here the authors perform a high-throughput screen to identify compounds that stimulate or repress the splicing of neuronal microexons. One of these compounds rescues the...

nature.com
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Oded Rechavi
@OdedRechavi
29 Jul 2024
It took more than a DECADE... but finally it’s published!!! It started as a CRAZY idea but after tons of hard work we built it: We hijacked the endogenous secretion systems of Toxoplasma gondii, a brain parasite, to deliver active proteins to neurons 👇 nature.com/articles/s41564-0…

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Eileen Furlong@Eileen_Furlong
29 Jul 2024
A heads up to all post-docs - the Genome Biology dept @EMBL is recruiting - independent group leader (PI) position. Outstanding colleagues, students, world-leading core facilities in a very supportive, collaborative and family environment, #jobs. Ad will be posted in next days
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Subramaniam Lab
@arvind_rasi
26 Jul 2024
RNAs are spliced, translated, and degraded in cells. How do we identify the cellular factors that control these RNA metabolic events in human cells? To tackle this question, grad student Patrick Nugent has developed an RNA-linked CRISPR screening technology called ReLiC. 1/
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Miha Modic@paraspeckle
26 Jul 2024
How can cellular signalling swiftly & selectively remodel the transcriptome to drive biological transition? How this switch is orchestrated has been a mystery... 🧵 nature.com/articles/s41594-0…
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Marta Melé@marta_mele_m
24 Jul 2024
Postdoctoral position open in Barcelona!! The @mele_lab is looking for computational biologists interested in large-scale transcriptome data analysis. Check out our website bsc.es/discover-bsc/organisa… & e-mail me with a CV and a motivation letter before August 31st!

Research Structure

Departments Computer Sciences Life Sciences Earth Sciences Engineering (CASE)

bsc.es
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Johannes Gräff@GraeffJohannes
25 Jul 2024
And it’s out!! Check out the newest paper from our lab on how chromatin plasticity predetermines neuronal selection for memory trace formation | science.org/doi/10.1126/scie… 🧵

Chromatin plasticity predetermines neuronal eligibility for memory trace formation

Memories are encoded by sparse populations of neurons but how such sparsity arises remains largely unknown. We found that a neuron’s eligibility to be recruited into the memory trace depends on its...

science.org
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Nima Dehghani
@neurovium
5 Jul 2024
Review, cortical cells @NeuroCellPress cell.com/neuron/fulltext/S08…

Making Ramón y Cajal proud: Development of cell identity and diversity in the cerebral cortex

In this review, Di Bella et al. provide a comprehensive overview of our current understanding of the multifactorial mechanisms that govern cellular diversification in the cerebral cortex, from...

cell.com
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