ALT Smita Krishnaswamy is an Associate Professor in the department of Genetics and Computer Science in the Yale School, a core member of the Program in Applied Mathematics, Computational Biology and Interdisciplinary Neuroscience. She is also affiliated with the Yale Center for Biomedical Data Science, Yale Cancer Center, and Wu-Tsai Institute. Smita’s research focuses on developing deep representation learning methods that use mathematical concepts from manifold learning, data geometry, topology and signal processing. to denoise, impute, visualize and extract structure, patterns and relationships from big, high throughput, high dimensional biomedical data. Her methods have been applied variety of datasets from many systems in cancer biology, immunology, neuroscience, and structural biology.