Jan 15
Our faculty member, Dr. @DeepaSubramany4, talks about her group’s #research that has revealed a novel role played by the clathrin light chain, CLCa in embryonic development. Read about it here: life-science-alliance.org/co…
#CellBiology #EmbryonicDevelopment
@DrJitendraSingh
DBT Success Stories 2025 | In Spotlight
Uncovering the molecular machinery that shapes early development.
Researchers at @DBT_NCCS_Pune have revealed a critical role of clathrin light chains in early mammalian development, highlighting how intracellular trafficking and cytoskeletal organisation influence signalling, a key pathway in embryogenesis.
🧬 Research insights shared by Dr. Deepa Subramanyam, BRIC–NCCS
Work led by Dr. Mahak Tiwari, published in Life Science Alliance (2025)
#DBTSuccessStories #CellBiology #Endocytosis #Biotechnology
@DrJitendraSingh
@rajesh_gokhale
@BricDbt
@NABI_India @bric_ils @NIPGRsocial @NImmunology
@DBT_NBRC @FollowDbtNibmg @HydNiab @BRIC_CDFD @DBT_NCCS_Pune @ICGEB @DBT_inStem
@RGCB_Trivandrum @THSTIFaridabad @unescorcb
@BIRAC_2012
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21 Dec 2025
#Ancient viral DNA elements, once considered "junk," play a pivotal role in activating gene networks during early #EmbryonicDevelopment and may inform new therapies for muscle wasting diseases. @ScienceAdvances doi.org/hbgbpd phys.org/news/2025-12-ancien…
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14 Dec 2025
Excited to share my first-ever publication, now out in @stemcellreports!! Special congrats to @Hemantcnaik666 and @BaroRunumi for jointly leading the work. Grateful to @srimontagayen for giving me this opportunity.
#m6A #epigenetics #EmbryonicDevelopment
Delighted to share our publication in @stemcellreports on the role of #m6A_RNA methylation in #Xchromosome dosage compensation during #embryogenesis, jointly driven by @Hemantcnaik666 and @BaroRunumi.
Acknowledge @iiscbangalore and @EMBO.
🔗shorturl.at/jfRzg
@ISSCR
🧵
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16 Sep 2025
Researchers develop a #MathematicalModel for hunchback gene expression in fruit flies and find that both self-regulation and diffusion are essential for the formation of the sharp gene expression boundaries that are key to #EmbryonicDevelopment.
🔗 go.aps.org/3IdbZti
ALT Three images showing hunchback, Hb, boundary formation. On the top is a schematic of a sharp Hb profile and exponential Bicoid, Bcd, profile along the anterior-posterior axis. Below is an illustration of how bistability, depicted on the left as a series of blue lines that make a 90 degree zig zag, could promote a sharp transition between states but increase positional variability. On the right, diffusion, shown as a series of smooth blue curves, could reduce variability but also reduce sharpness. Below, depicted using four black outlined circles with blue and red circles inside, Hb is shown as being activated by both Bcd and itself; it then degrades and diffuses among cell nuclei.
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8 Sep 2025
REVIEW: Timing is everything: transcription bursting in development
By Jee Min Kim and Daniel Larson
➡️ tinyurl.com/gd352465
#transcription #molecularbiology #transcriptionbursting #embryonicdevelopment #stemcell #differentiation #mRNA #development #molecularmechanism
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6 Jul 2025
Absolutely mesmerizing! The intricate dance of life unfolding before our eyes. #EmbryonicDevelopment #ScienceWonders #TimeLapseMagic
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29 Jun 2025
#A newly identified DNA "attenuator" acts as a genetic dimmer switch, precisely controlling #GeneExpression during #EmbryonicDevelopment and enabling the formation of diverse cell types. doi.org/g9rq53 phys.org/news/2025-06-scient…
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29 Jun 2025
#A newly identified DNA "attenuator" element acts as a genetic dimmer switch, precisely tuning #GeneExpression during #EmbryonicDevelopment and shaping diverse cell types. doi.org/g9rq53 phys.org/news/2025-06-scient…
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🔬 NEW RESEARCH ALERT: #IETSPapersOfTheMonth 📊
@Tongji_Uni researchers found oral exposure to #Nanoplastics in male mice led to early #EmbryonicDevelopment abnormalities & changes in reproductive #GeneExpression profiles in @FrontiersIn. Read more ▶️ doi.org/10.3389/fcell.2025.1…
ALT #IETSPapersOfTheMonth Exposure to polystyrene nanoplastics impairs sperm metabolism and pre-implantation embryo development in mice Liu Y, Hao F, Liang H, Liu W, Guo Y. 2025. Frontiers in Cell and Developmental Biology 13, 2025. APRIL 2025
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15 May 2025
محققین کا کہنا ہے کہ یہ مشاہدات پیدائشی دل کی بیماریوں کی تشخیص کرنے میں مدد دے سکتے ہیں
مزید پڑھیئے: aaj.tv/news/30460581
#AajNews #HeartFormation #MedicalBreakthrough #EmbryonicDevelopment #ScienceDiscovery
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Lab meeting with the Zenker Lab
In our latest 'Lab meeting' post, we meet the Zenker lab @LabZenker, based @ARMI_Labs in Melbourne, Australia. The lab is interested in all things #StemCells, #EmbryonicDevelopment and #LiveImaging.
Meet the Lab:
thenode.biologists.com/lab-m…
ALT Zenker lab group photo
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SRF: A New Regulator of Retrotransposons and Genes in Early Embryonic Development🧬
A team led by Prof. Maria-Elena Torres-Padilla, #HelmholtzMunich, has uncovered a key player in early embryonic development: SRF.
👉t1p.de/d87p5
💡 This factor regulates retrotransposons - once thought of as mere "jumping genes" - and essential genes at the first moments of life.
🔬 Key Findings:
🌟 MERVL, a retrotransposon, helps regulate genome activation post-fertilization.
🌟 Transposons are not just genetic disruptors but also shape gene regulation.
🌟 The evolution of transcription factor binding sites has driven genome organization.
This discovery deepens our understanding of gene regulation, evolution, and disease, shedding light on the earliest stages of life.
@METorresPadilla
#EmbryonicDevelopment #Genomics #Transposons #StemCells #Evolution #Epigenetics #GeneRegulation
ALT SRF: A New Regulator of Retrotransposons and Genes in Early Embryonic Development
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24 Feb 2025
The process of development of an embryo from a cell to a human being.
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#EmbryonicDevelopment #HumanDevelopment #CellToHuman #Embryology #FetalDevelopment #LifeCycle #MedicalScience #ReproductiveHealth #Genetics #Pregnancy #DevelopmentalBiology #ScienceEducation #HealthAwareness #Anatomy #Biology
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30 Jan 2025
#Metabolic activities selectively influence the segmentation clock in #EmbryonicDevelopment, varying by species. They are not universal modulators of developmental speed across all species. @NatureComms doi.org/g83n4w medicalxpress.com/news/2025-…
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4 Jan 2025
Scientists Cultivate First Human Notochord in Lab, Unlocking Secrets of Spinal Development
Scientists at The Francis Crick Institute in London have achieved a scientific milestone by cultivating notochord tissue from human stem cells, providing a breakthrough in understanding embryonic development. The notochord, often described as the "GPS for the developing embryo," is pivotal in guiding the formation of the spine and nervous system. Historically, replicating this essential tissue in the lab has been elusive due to the complexity of the biological signals required at precise times during development.
To overcome this challenge, researchers studied the developmental processes in chicken, mouse, and monkey embryos, gaining insights into the molecular cues necessary for notochord formation. Using this knowledge, they engineered a stem cell model that developed into a small, trunk-like structure, stretching 1 to 2 millimeters, which included correctly positioned neural tissues and bone stem cells.
This model, while minute, demonstrates functional notochord behavior, sending out chemical signals to organize surrounding tissues as it would in a developing embryo. This capability could significantly enhance our understanding of spine-related congenital anomalies and the pathology of intervertebral discs, which are derived from the notochord and serve as shock absorbers between vertebrae.
The study, published in the journal “Nature,” signifies a leap forward in developmental biology, potentially illuminating the mechanisms behind spinal and neurological birth defects. James Briscoe, the senior author, highlighted the model's role in opening new avenues for research into developmental disorders, while Tiago Rito, the study's first author, emphasized the excitement of witnessing notochord functionality in a controlled lab environment.
#Notochord #StemCellResearch #EmbryonicDevelopment #SpineResearch
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Demonstration of the toxic effects of #CopperOxideNanoparticles (CuONPs) on mouse preimplantation #EmbryonicDevelopment and an assessment of #ReproductiveHealth hazards associated with CuONPs exposure.
#OpenAccess: go.acs.org/bAJ
ALT TOC image from the article
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🐟 #Zebrafish hold great value for a range of different research areas.
🔬 This ranges from basic research (eg. #EmbryonicDevelopment) as well as newer, emerging fields such as #nanomedicine & #RegenerativeMedicine!
#AnimalsInResearch
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3 Oct 2024
Plenary Lecture 2 in 15min 🚀@Eileen_Furlong Head of Genome Biol. Dept @EMBL sheds light on gene expression regulation and the role of enhancers in embryonic development. 🔬 #conwayfest24 #Genomics #GeneRegulation #EmbryonicDevelopment
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🗣️ Have you seen the newest episode of #TransparencyThursday?
🔬🐁 It features Moisés Mallo, from EARA member @IGCiencia, who explains his work on #EmbryonicDevelopment using #mice!
Check out the video here: youtu.be/5QcJ6bTNhL8
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29 May 2024
New #deepLearning model uses video to measure #embryonicDevelopment @PlymUni phys.org/news/2024-05-deep-v…
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