It's possible - rewards go up when people leave, usually

I wonder if a large chunk of crunchers quit.

Thanks for checking. Hmm, interesting- wonder if it'll last 🤔

Yeah. Major boost.

Not sure if it's related to the bug, or the markets. Just wanted to see if others were experiencing the same.

Wow. Interesting. I'll go look.

Not sure what happened this week, but I suddenly started getting 5x the rewards from my @GridcoinNetwork rig all of a sudden. A beneficiary of the market turbulence? GRC is the farthest removed coin in the Web3, after all - not complaining about it, either way. @JestemZero - there's been a mandatory hotfix that they just launched btw. My rig was crashing the last few days and I think they patched it.

I dunno, most of the wallets I've seen on any chain tends to be pretty bad. Metamask has always been awful and the L2s just make it more confusing to use. @GridcoinNetwork has a good one where the wallet and governance functions are well integrated but they're even more obscure than Tezos is - they're probably the most serious project in the Web3 space right now but they're not even listed on most exchanges because they prefer to keep to themselves. The rest of the chains have the problem of them not taking governance seriously enough to integrate it into their apps - I feel like a lot of Tezos wallets just blindly followed those bad habits and did themselves an injustice by copying the "market leaders", even though they don't really know what they're doing, either. Money talks, BS walks, as they say. At teia.cafe and @TeiaCommunity we attempted to create bridges between the baking community and other parts of the ecosystem but it makes the most sense for this stuff to be done at the wallet level where the interaction actually takes place. Just basic stuff like voting records and a clearer indication of delegation vs staking, with a quick explainer could go a long way. Kind of a shame because I know how seriously the community takes the governance part seriously...if only that was actually articulated in the UI...

DeSci’s market cap has reached $384M as AI agents compress peptide drug discovery into 24-hour research pipelines. But the real breakthrough is not the tokens, it’s the open-source biotech infrastructure replacing traditional pharma research systems. Here’s the real state of DeSci 2026. — ● The Open-Source AI Stack Powering DeSci The current DeSci momentum accelerated after peptAI reportedly designed an ADHD peptide candidate in 24 hours for only a few thousand dollars. Historically, drug discovery required years of research, massive pharma teams, and millions in upfront R&D. The infrastructure driving this shift includes: • OpenFold3 (by @open_fold) : open-source protein folding infrastructure. • RFdiffusion3 (by lead researcher @r_krishna3) : AI-driven protein and peptide generation. • Boltz-2 ( @Boltz_bio ): high-speed protein binding prediction. • ChEMBL ( @ChEMBL ) : open database with millions of bioactive compounds. • Federated protein training : collaborative biological AI training. • AI peptide agents : autonomous peptide discovery systems. • Bioactivity databases : open molecular research infrastructure. The real shift is biotech infrastructure moving from closed pharma systems onto open-source software rails. Projects like @Peptoma_xyz, @peptome_ai ( $PEPT ), @clarity_proto ( $FOLD ), and @BioLLM_ are building around AI-driven peptide discovery and on-chain biotech funding. — ● The Timeline Bottleneck AI Still Hasn’t Solved AI is accelerating discovery pipelines, but clinical validation remains the hardest challenge in biotech. Phase I: confirms the drug is safe for further testing. Phase II: determines whether the treatment actually works. Phase III: validates efficacy and safety before regulatory approval. AI is improving research speed and molecule discovery, but drug development still operates on multi-year timelines. No AI-designed drug has completed Phase III yet. — ● Updated 2026 DeSci Ecosystem Landscape Despite remaining a sub-$400M sector, DeSci led 24H narrative performance with a 1.64% gain while most major sectors stayed in red. The ecosystem is now expanding across specialized bioDAOs, AI-native discovery, scientific infrastructure, tokenized IP, and analytical tooling. • Capital Coordination Layer : funding decentralized scientific research. @vitadao @athenabiorg @anagenxyz @psy_dao @cryodao @spark_sciences @Spine_DAO @endrarediseases @QuantumBioDAO @Cerebrum_DAO @GenomesDAO @PoSciDonDAO @daohydra @eticaprotocol • AI Discovery Layer : AI-native drug discovery and biological modeling. @GeneStackDeBio @BioLLM_ @clarity_proto @Aubrai_ @Rejuve_AI @DeSci_Agents @cyberphysicsai • IP & Commercialization Layer : tokenizing biotech intellectual property. @Molecule_sci @AxonDAO • Data & Infrastructure Layer : decentralized scientific data and compute infrastructure. @origin_trail @GaleonCare @Hippo_Protocol @BluzelleHQ @GridcoinNetwork @dynexcoin @DataLakeToken @silencioNetwork • Publishing & Knowledge Layer : open-access publishing and peer review systems. @ResearchHub @nobleblocks • Consumer & Speculative Layer : retail biotech participation and experimental markets. @pumpdotscience @Open_Genome @D1ckGPT @peptidefolio • Analytical Tools : DeSci analytics, dashboards, and sector intelligence. @desciatoms @DeSciDashboard @TrackedBio @TBDeSci — ● Where DeSci Is Falling Behind DeSci still struggles with the mismatch between crypto’s short-term capital cycles and biotech’s long research timelines. Markets are pricing scientific potential far earlier than clinical validation, while funding volatility and governance inefficiencies continue slowing long-term research execution. That remains the biggest structural weakness in the DeSci narrative today. — ● Bull Case For DeSci The long-term opportunity is DeSci evolving into a new financing layer for biotech research. AI lowers research costs → bioDAOs fund experiments → IP gets tokenized → successful discoveries generate licensing revenue. That is why the global DeSci funding DAO market is projected to grow from $120M in 2025 to $520M by 2034, reflecting a 17.7% CAGR as scientific funding increasingly moves on-chain. — ● Bear Case For DeSci DeSci still faces major risks around regulation, DAO governance, tokenized IP legality, and integration with traditional academic institutions. Many early-stage DeSci projects still struggle with sustainable funding, researcher onboarding, and maintaining scientific rigor during speculative market cycles. The infrastructure trend is real, but scalable adoption and long-term value capture remain largely unproven. Still, DeSci remains one of the few crypto sectors attempting to build long-duration infrastructure beyond purely financial speculation.

Not sure what happened with @GridcoinNetwork this week but I'm not complaining. It's very volatile but $GRC is a high-quality project that's mostly unknown and isn't even connected to most exchanges right now. It literally has nowhere to go but up. 👀

@GridcoinNetwork is the only valid use case I can think of for PoW at this point. At least the crunching goes to something useful. I do think that PoS is now the defacto standard for crypto now, though. It'll take some time but the markets will catch up eventually, too.

@GridcoinNetwork and @BOINCNetwork is still alive and updating, folks. And run by some of the smartest, best people out there.👌 @JestemZero

Is this the new update? The progress screen for @GridcoinNetwork just got more fancy 🤩

Happy the @GridcoinNetwork rig is up and running again. Doing strange things with your computer was where it all originally started with crypto. It's time we started doing that again. 💪🦾🤳

Man, it took forever to figure out how to get the beacon system working but I finally did it. @GridcoinNetwork! It's like crypto-mining, but with the energy actually going towards something useful. 😁 Still one of the best projects in the Web3 space - not even listed on centralized exchanges yet. Reminds me a lot of the early days of crypto where things were more quiet...and smarter. @JestemZero - how's your rig doing? Staking seems to be pretty lucrative these days probably because the pools are so small now. $GRC

So far the markets have been behaving exactly as predicted, with projects with high decentralization (@tezos, @cosmoshub, @decentraland, @GridcoinNetwork) staying resilient (i.e. they go down less) while the rest of the markets start to tank. As corporate interest start to pull out, they take everyone down with them, but the more true believers doing self-custody there are the less they get affected by downturns like these. You know what the silver lining in all of this really is? $XTZ (9-10%), $ATOM (10-15%), and $GRC (1.5% but the rewards are more frequent due to how small the project is atm) all has very generous staking rewards that help cushion the blow a bit assuming you've been staking your coins diligently. When the markets recover, the returns on these projects will be outsized because you're being rewarded by more coins per price action. With BTC you're straight outta luck, with ETH (3-4%) you'll be searching for crumbs. If you're gonna go for it anyway, go big or go home, I say. #Tezos - the least-worst crypto project in Web3. 🤣

Aaaaand, we're right back down again. I'm seeing the same type of memecoin-esque activity around gold and silver like we've seen with meme-stocks and crypto over the past few years. The interesting thing about this whole fiasco is that precious metals has the same issue as Bitcoin around the idea of "self-custody" - holding your own coins in your Bitcoin wallet is the equivalent of someone actually buying the metal itself and storing it in their homes, on-site. How many people actually do that? If you're buying this stuff under Wall Street's custody, you might as well just give your money to a hedge fund instead. 😅 Anyway, the "what's a real hedge?" question is still anyone's game. Out of all the things out there, #Tezos still makes the most sense to me right now. Oh, and it's kind of nice that @GridcoinNetwork has started to do well recently, too. 🤞

In this call we talked a lot about privacy and @tezos' new "shielded transactions" feature - the challenges of balancing people's need for privacy vs the system's need for transparency, which is a trickier problem than most people think. All these features are neat to have, but haven't really shown up on the UI side of things...which I think would ideally be integrated with wallet systems to make the ecosystem more legible. I really want to be able to see the governance side of things come to life, too - been doing some work with @GridcoinNetwork lately and I think their wallets are very well designed. There's some ideas here worth emulating, imo. - Direct wallet-to-wallet messaging (we have this as teia.cafe but honestly, this should be done at the protocol level) - Integrated multi-wallet addresses (great for record keeping and business use) - Stake splitting (would very useful for orgs like @TeiaCommunity) - Wallets can be used by regular users, stakers, and researchers and is integrated in a seamless fashion (I think it's important for crypto communities to have a unified experience when it comes to their interfaces, personally) As a Tezos maxi I rarely say nice things about other projects (😂) but this is one case where $GRC may be ahead of us in certain ways. I'd like to see the UI side get up to par with projects like these because I get a lot of complaints about these tools being too confusing when onboarding people. cc @JestemZero - I finally got my rig up an running - still waiting for beacon activation. It's nice to see that they've still been working on improvements in the last few years, though!

I was able to sync in only a few hours too instead of a day plus like before.

They did some updates to the wallet and the UI us actually pretty nice now. Worth checking out!