assume-breach is theater. ai-native security is real. your data architecture IS your security architecture now. hypersegmentation ai orchestration = actual defense. data leaders... this is your moment. #AI #DataStrategy #FractionalCDO #DataLeadership

Technology doesn't replace the Relationship Manager (RM); it empowers them. In a hyper-segmented world, AI provides the "nudges" and granular insights that allow RMs to focus on long-term strategic growth and high-value opportunities. Read more about shifting the RM focus from reactive facilitator to proactive advisor. Download the full report: delo.tt/6012BBxEOj 🟢 #DeloitteAfricaFSI #HyperSegmentation #RelationshipManagement #BankingInnovation #StrategicGrowth

Dr. David Spetzler, President at Caris Life Sciences made some important comments in the panel on cancer screening at the at the Inaugural National Caris Precision Oncology Alliance Member Meeting at @BrownUniversity @carisls He spoke about “multiplicity and the hypersegmentation problem” as causing “the risk of false discovery to go up” and driving up the sample size. He spoke about cofounders, the need to address the complexity of biology. Dr Spetzler also said “unnecessary interventions need to be minimized.”

megaloblastic changes, most commonly due to: Vitamin B12 deficiency, Folate deficiency Pathophysiology: Defective DNA synthesis impaired nuclear maturation, cytoplasmic maturation continues , nuclear-cytoplasmic asynchrony , hypersegmentation. Clinical correlation: Often seen in: - Megaloblastic anemia - Malabsorption states •Chronic alcoholism •Certain medications (e.g., methotrexate) From a broader perspective, this reflects deficient methylation and nucleotide synthesis, where: •B12 (cobalamin) and folate are central •Orthomolecular correction: methylcobalamin 5-MTHF •Supportive: B-complex, zinc, gut optimization (absorption) The neutrophils are hypersegmented, indicating a megaloblastic process (B12/folate deficiency until proven otherwise).

Diagnosis: Hypersegmented Neutrophil Key Observations ➤ Hypersegmentation: The neutrophil in the image clearly displays six or more nuclear lobes (segments) connected by thin chromatin filaments. ➤ Morphology: While a normal neutrophil typically has 3 to 5 lobes, this cell exceeds that limit, which is a hallmark hematological finding. Clinical Significance ➤ Megaloblastic Anemia: This is most commonly associated with Vitamin B12 deficiency or Folate (Vitamin B9) deficiency. ➤ Early Marker: Hypersegmentation is often the first sign of megaloblastic changes, appearing in the peripheral blood even before macrocytosis (enlarged red cells) develops. ➤ Other Causes: It can also be seen in cases of long-term chemotherapy (antimetabolites) or rare genetic conditions. Summary (Ultra-Short) ➤ Condition: Hypersegmented Neutrophil. ➤ Primary Cause: Megaloblastic Anemia (B12/Folate deficiency). ➤ Definition: Presence of ≥ 6 nuclear lobes in a single neutrophil.

Erythroid (RBC precursor) dysplasia 1. Binucleation What it means: One erythroblast has two nuclei Why it happens: Faulty cell division Significance: Classic sign of dyserythropoiesis in MDS 2. Multinucleation What it means: More than two nuclei in one erythroblast Significance: More severe erythroid dysplasia 3. Nuclear budding What it looks like: Small “buds” protruding from nucleus Meaning: Defective nuclear maturation High-yield: Strongly suggests MDS 4. Nuclear irregularity / karyorrhexis What it means: Abnormally shaped or fragmented nucleus Exam tip: Think ineffective erythropoiesis 5. Megaloblastoid change What it looks like: Large erythroblasts with immature nuclei but mature cytoplasm Looks like: B12/folate deficiency Key point: In MDS, B12 & folate are normal 6. Ring sideroblasts Definition: ≥5 iron granules encircling ≥1/3 of nucleus Cause: Mitochondrial iron trapping Seen in: MDS (especially SF3B1 mutation) Alcohol, drugs (INH), copper deficiency ⚪ Granulocytic (myeloid) dysplasia 7. Pseudo–Pelger–Huët anomaly What it looks like: Neutrophil with bilobed or unilobed nucleus Key feature: Hyposegmented nucleus High-yield: Very characteristic of MDS 8. Hypogranulation What it means: Neutrophils lack normal granules Slide clue: Pale, “empty” cytoplasm Clinical impact: Poor neutrophil function → infections 9. Abnormal nuclear segmentation Includes: Hypersegmentation or bizarre shapes Meaning: Faulty maturation Megakaryocytic dysplasia 10. Micromegakaryocytes What they are: Abnormally small megakaryocytes Nucleus: Single or bilobed (instead of multilobed) Very typical for MDS 11. Hypolobated nuclei What it means: Megakaryocyte nucleus has too few lobes Exam pearl: Think MDS rather than ITP 12. Separated nuclear lobes Appearance: “Pawn-ball” or widely separated lobes Significance: Dysplastic megakaryopoiesis

In marketing speak I fear Spotify are guilty of hypersegmentation....

Speaking of data. Do you know that if you wanted to run certain campaigns without an already established database that hyper segmentation is harder? And so hypersegmentation really just takes off with data accumulation as data laws and P&C policies restrain a lot of data. So, I was brainstorming with someone on some campaigns in a specific sector and we were building a brief to guide design, comms etc but could not get access on racial distribution on a specific department in a sector in the EMEA region. We have read multiple papers and even looked at company group pictures to try to figure this out to no avail😭🤧 Only solution now is a market research org or we will commission sales to find ways to figure out ethnicity when doing demo calls. All this to say that on the surface, recording data such as this might be misconstrued as something that could be weaponized for racism, however, what if regulatory bodies factored in nuanced use cases of data in such a way that it can be used for good while streamlining it’s abuse?

🧫 Neutrophil Hypersegmentation — Hema Pearls 🧠🧬 🔍 Definition: ≥5 lobes in ≥5% of neutrophils (or ≥6 lobes in any cell) 🔬 🚨 Main Causes: 1️⃣ Megaloblastic anemia 💉  ➡️ Vit B12 deficiency 🧀  ➡️ Folate deficiency 🥦  📍DNA synthesis impaired → nuclear maturation delay 2️⃣ Cytotoxic / Antimetabolite drugs 💊  ➡️ Methotrexate, Hydroxyurea, Azathioprine, 6-MP, Cytarabine 3️⃣ Myelodysplastic syndrome (MDS) 🧬  ➡️ Dysplasia → abnormal nuclear segmentation 4️⃣ Chronic infection / Inflammation 🔥  ➡️ Reactive hypersegmentation occasionally seen 5️⃣ Iron deficiency anemia (rare) 🍖  ➡️ Borderline changes mimicking megaloblastic picture 6️⃣ Uremia / Liver disease 💧  ➡️ Metabolic effects on marrow maturation 🩺 OSCE Tip: 💬 “Peripheral smear shows hypersegmented neutrophils — next test?” ✅ Serum B12 & Folate levels 📚 Ref: •Bain BJ. Blood Cells: A Practical Guide, 6th Ed, 2025. •Hoffbrand AV et al., Postgraduate Haematology, 8th Ed, 2023. #HemaPearls 🧬 #Neutrophils #Hypersegmentation #B12 #Folate #MDS #Hematology

This has been a recurring topic around here for the past years. If not mistaken, @Recuenco has been talking about this and hypersegmentation (maybe not the right word) in the ES community for years, and it has been mentioned in some major podcasts such as TF

Hurler Syndrome (HS) is a lysosomal storage, X-linked autosomal recessive disorder of the aminomucopolysaccharide Type IH (MPS-IH). It is caused by the excessive build-up of glycosaminoglycans (GAG) in lysosomes. It is caused by mutations on chromosome 4 (4,p16.3) with deficiency in alpha-L-iduronidase enzyme leading to lysosomal degradation. It causes organ systems damage in CNS, skeletal, corneal, and heart. Abnormal changes appear by 3 months of age with progressive developmental and mental deterioration. There's a large head, frontal bossing, and short stature. By age 4 years, there's a developmental arrest. Diagnosis: amniocentesis, and genetic testing. Hurler syndrome is characterized by neutrophil hypersegmentation and the presence of Alder-Reilly inclusions on histopathology. The accumulation of glycosaminoglycans, protein-carbohydrate complexes within lysosomes, form the specific and pathognomic Alder-Reilly inclusions of Hurler Syndrome. Ddx. Other types of mucopolysaccharidosis types like Hurler-Schei and Schei syndromes, which are milder forms. Tx. Enzyme replacement therapy with iduronidase, corneal surgery, surgical bone corrections, and hematopoietic stem cell transplantation (HSCT).

Although the case presented suggests #thalidomide-induced #phocomyelia, this drug is no longer used to treat morning sickness since it was strictly prohibited during #pregnancy in 1962, after its association with birth defects in babies of mothers who had taken it was discovered. Thalidomide's use is currently restricted to multiple myeloma and erythema nodosum leprosum. Less common uses include inflammatory diseases such as sarcoidosis and Behçet's disease, and some dermatological conditions such as actinic prurigo and adult Langerhans histiocytosis, among others. Phocomelia can also be associated with different genetic syndromes, including: ◦ Roberts Syndrome: A rare autosomal recessive disorder caused by a mutation in the ESCO2 gene that manifests with severe limb malformations and craniofacial defects. ◦ Thrombocytopenia with radial aplasia: A rare autosomal recessive disorder related to the RBM8A gene that presents with thrombocytopenia and limb radial deficiency. ◦ Syndrome of severe limb defects, vertebral hypersegmentation, and mirror polydactyly: An autosomal recessive disorder resulting in severe limb hypoplasia with polydactyly and hypersegmentation of the spine.

Although the case presented suggests thalidomide-induced phocomyelia, this drug is no longer used to treat morning sickness since it was strictly prohibited during pregnancy in 1962, after its association with birth defects in babies of mothers who had taken it was discovered. Thalidomide's use is currently restricted to multiple myeloma and erythema nodosum leprosum. Less common uses include inflammatory diseases such as sarcoidosis and Behçet's disease, and some dermatological conditions such as actinic prurigo and adult Langerhans histiocytosis, among others. Phocomelia can also be associated with different genetic syndromes, including: ◦ Roberts Syndrome: A rare autosomal recessive disorder caused by a mutation in the ESCO2 gene that manifests with severe limb malformations and craniofacial defects. ◦ Thrombocytopenia with radial aplasia: A rare autosomal recessive disorder related to the RBM8A gene that presents with thrombocytopenia and limb radial deficiency. ◦ Syndrome of severe limb defects, vertebral hypersegmentation, and mirror polydactyly: An autosomal recessive disorder resulting in severe limb hypoplasia with polydactyly and hypersegmentation of the spine.

Neutrophil hypersegmentation and Alder-Reilly inclusions in Hurler Syndrome, a genetic mucopolysaccharidosis type 1H disorder caused by deficiency in alpha-L-iduronidase leading to defective lysosomal degradation of glycosaminoglycans and the accumulation of these protein-carbohydrate complexes within lysosomes forming the Alder-Reilly inclusions.

The relationship between neutrophil hypersegmentation and Hurler syndrome has yet to be described. ow.ly/clHp50Vue9Y #BloodWork #phagocytesgranulocytesandmyelopoiesis

Segmentation is completely useless in this post I’m gonna show you all you need to know about segmentation so you do not run into low deliverability overworking just to send to micro segments not understanding why people do not buy there’s this myth that you need to personalise everything if you hold on for a second you realise it’s completly fluff Most of your subscribers do have something in common and it’s interest in your brand so as long as you don’t sell dog food & beauty products on the same store you can pretty much send to the entire list whenever you hit send But ye you’re right In theory we would love to send a personalised msg to all 158293 people on the list And don’t get me wrong you would probably see better results than sending 1 email to everyone But the required work just does not add up Less work focus on other levers to pull shotgun approach > more work hypersegmentation sniper approach so here’s what you need: You send to –> ENG X days. This can be 60,90,120,180D whatever you want and is mainly dependend on how good your deliverability is. Engaged for us means: Opened or clicked email More important than who you’re sending to is who you’re NOT sending to So here are the segments we do not send to: List clean 1 (people who received 15 or more emails but haven’t opened 1) List clean 2 ( people who marked email as spam, email bounced, email dropped at least once) List clean 3 (past purchasers last 14D) That way you do not run into deliverability issues and your past purchasers will not get annoyed after just placing an order And that’s it No overcomplication needed

Hypersegmentation des cibles : Grand public : Campagne massive sur les réseaux sociaux avec des messages rassurants : "Nous écoutons vos préoccupations et travaillons à des solutions." Médias : Invitations à des conférences de presse où des experts indépendants

tempted to say LGLL given RA but large cell does not appear granular. No hypersegmentation but folate def in differential esp if patient on MTX. Counted 3 schistocytes and not seeing any platelets so would get hemolysis labs to r/o MAHA. A bite cell, will review meds for G6PD.

Botryoid neutrophil (radial hypersegmentation) secondary to heat stroke.

sorry I’m not an academic in this world, but is the hypersegmentation of real estate markets not taken for granted? this seems both logically and empirically obvious