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Exciting times ahead for spatial biology and human tissue biology! 🚀🧬
#SpatialOmics #SpatialBiology #RNAmodification #m6A #NatureMethods
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New study from 'Genes to Cells' reveals how m6A RNA modification controls HTLV-1 Tax expression and reshapes host gene programs—highlighting viral latency mechanisms and potential therapeutic intervention and prophylaxis. #RNAmodification #epigenetics ➡️ow.ly/jscj50XTe0F
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Raw signal segmentation for estimating RNA modification from Nanopore direct RNA sequencing data. #RNAmodification #Nanopore #RNA #Sequencing @biorxiv_bioinfo biorxiv.org/content/10.1101/…
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🧬Fresh RNA modifications newsletter out now: viral tRNA hijacking, hidden rRNA mods, dynamic Ψ, antibiotic resistance & more. 👉open.substack.com/pub/rnamod… #Epitranscriptome 🦠 #RNAmodification #ribosome

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🚨 New Publication in JCA! 🔬 Epigenetic and epitranscriptomic regulation of cardiac metabolism in aging and disease Junxi Liu, Mocun Yang, Boda Zhou 📖 Read here: oaepublish.com/articles/jca.… #Cardiology #Epigenetics #Aging #RNAmodification #Metabolism
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Postdoc interested in investigating the role of A-to-I editing in prostate cancer? Join us! Postdoc Opportunity – RNA Editing & Prostate Cancer Research Lund University See the full job description on jobRxiv: jobrxiv.org/job/lund-univers… #Epitranscriptome #prostatecancer #RNAEditingMechanisms #RNAmodification #ScienceJobs jobrxiv.org/job/lund-univers…
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21 Jul 2025
We're excited for the fourth edition of #EMBLEpitrans, how about you? 🙌 Join us as we highlight recent developments and focus on future aspects and current challenges in the RNA field at the EMBO Workshop 'The epitranscriptome' 🔍 ➡️ s.embl.org/etc25-01-x 📩 Submit your abstract by 5 August 🗓️ 28 – 30 October 📍 EMBL Heidelberg and Virtual 💠 You can look forward to hearing from the top leaders in the field: Sandra Blanco, Salamanca Cancer Research Center (CIC), Spain Chuan He, The University of Chicago, USA Stacy Horner, Duke University, USA Jean-Yves Roignant, University of Lausanne, Switzerland Julian König, University of Würzburg, Germany Eva Kowalinski, EMBL Grenoble, France Kate Meyer, Duke University, USA Eva Maria Novoa, Centre for Genomic Regulation (CRG), Spain Dónal O'Carroll, The University of Edinburgh, UK Yanhong Shi, City of Hope, USA Tsutomu Suzuki, The University of Tokyo, Japan Jocelyn Widago, Queensland Brain Institute, Australia Anne Willis, University of Cambridge, UK Chengqi Yi, Peking University, China Yi-Tao Yu, University of Rochester, USA #EMBLEvents #geneexpression #RNAmodification #mRNA #RNA #transcriptome #epitranscriptome
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📊 Highlights from the study by @EmmanuelleHodar, @aubreemades, @DBsteh, @RhieSuhn, Lisa Swartz, Tong Xu, and Amir Goldkorn, published in CHP Journal 🧬 ▶️ How m⁶A RNA methylation links to enzalutamide resistance ▶️ Why THBS1 is a top epitranscriptomic hit ▶️ How THBS1 loss drives rapid ARPI resistance 🔬 Work from @KECKSchool_USC @uscnorris 🔍 Visual summary below 👇 #ProstateCancer #Epitranscriptomics #m6A #RNAmodification #DrugResistance #CHPjournal

ALT Slide 1 introduces the research question: How does m6A RNA methylation contribute to enzalutamide resistance in prostate cancer? The authors propose that RNA modifications drive adaptive transcriptional programs linked to drug resistance. Slide 2 presents the discovery: Using RNA-seq and MeRIP-seq, Hodara et al. identified 487 genes both differentially expressed and methylated. Among these, THBS1 showed increased m6A and reduced transcript levels in resistant cells, with findings supported by public datasets. Slide 3 highlights validation: Knockdown of THBS1 in enzalutamide-sensitive cells induced resistance, suggesting THBS1 as a regulator of ARPI response. This study provides the first epitranscriptomic landscape of ARPI resistance and positions THBS1 as a novel resistance driver in prostate cancer.

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Had an inspiring visit with Hongjun Song and Guo-Li Ming @AcadSinica , followed by an enchanting excursion to Sun Moon Lake. Grateful for the insightful discussions on #RNAmodification and #organoid advance topics and technologies! ✨🔬 @UPenn_SongMing @IMBSinica
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Are you ready for #EMBLEpitrans? Prepare to deep dive into advances in RNA modification functions, their key roles in gene expression, disease, and transformative therapies. Be part of the community🔬💡 📩 Submit your abstract by 5 August ➡️ s.embl.org/etc25-01-x 🗓️ 28 – 30 October 📍 EMBL Heidelberg and Virtual Session topics 🔸 RNA modification I (m6A) 🔸 RNA modifications in stem cells and development 🔸 RNA modification II (m5C, m1A, 3' terminal additions, etc.) 🔸 RNA modification pathways in physiology and pathology 🔸 Emerging concepts #EMBLEvents #geneexpression #RNAmodification #mRNA #RNA #transcriptome #epitranscriptome
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14 Nov 2024
Join us for an exciting seminar next week diving into groundbreaking work on designer organelles for precise mRNA pseudouridinylation! Discover how optimized RNA editing organelles (OREO) open new frontiers in targeted RNA modification 🔥 Don’t miss it! #RNAmodification #SynBio
12 Nov 2024
Join the next #EUSynBioSeminar to hear Lukas Schartel, PhD student from @LemkeLab @imprs_cbp, give a talk on "Selective RNA pseudouridinylation using circular gRNA in designer organelles" Scan the QR code or go to shorturl.at/mbNsL to register! 🧬
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Thank you @washumedicine Department of Cell Biology & Physiology for inviting me to speak about our exciting #lncRNA protein and #RNAmodification discoveries! If you find any #lncRNAs in your analysis, call me. 🙂 #SilvaFisherlab biorxiv.org/content/10.1101/…
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My continued biological education Epigenetic regulation of #Aging: implications for interventions of aging and diseases Beyond DNA & Histone epigenetic clock #RNAModification m6A m5C (Writer/Reader/Eraser) #RNAEditing in #Senescence Noncoding RNA Small-molecule anti-Aging therapy NAD precursor HDACi Metformin Rapamycin SGLT2i Senolytics (GPNMB vaccine) Will any of these outperform or synergize healthy eating/sleeping exercise?😁 Hope to read a bit more on sex-based aging trajectories🥸 @sigtrans_sttt 2022 nature.com/articles/s41392-0…
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Are you interested in #RNAmodification research? @VilardoElisa is a #PhD supervisor at #MedUniVienna and aims to deepen the understanding of how modifications in #RNA are distributed and regulated. Apply for our #PhDcall and read more about the project! ⬇ bit.ly/3Jcjn5b

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Happy to share a small piece from the talented technician Jiayi Kang in the lab. Thanks @ajpheartcirc @merrylindseyphd @AnnChiaoPhD for the invitation. #RNA #RNAmodification #aging
#ArticlesInPress: Unlocking the Dark Matter: Noncoding RNAs and RNA Modifications in Cardiac Aging Jiayi Kang, James Rhee, Chunyan Wang, Yolander Yang, Guoping Li, and Haobo Li ow.ly/6xCk50QJjRG @lihaobo @MassGeneralNews #NoncodingRNA #Aging #MicroRNA #LongnoncodingRNA
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De novo basecalling of m6A modifications at single molecule and single nucleotide resolution. #m6A #RNAmodification #DirectRNAseq @nanopore #sequencing @EvaMariaNovoa @biorxiv_bioinfo biorxiv.org/content/10.1101/…

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#research #Ap4A #RNAcap #RNAmodification Diadenosine Tetraphosphate (Ap4A) Serves as a 5’ RNA Cap in Mammalian Cells (Cahová): @angew_chem: doi.org/10.1002/anie.2023149… @CahovaB @IOCBPrague @CzechAcademy
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✳️ Thrilled to announce the new Graphical Review ´Co-transcriptional assembly mechanisms of protein-RNA complexes´ by Nusrat Qureshi & Olivier Duss 🧬 @OlivierDuss @embl @FEBSnews @LuciaCiglar ➡️ bit.ly/3Q9ITuO #Transcription #RNAfolding #RNAmodification #Splicing
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