George Pickens sobre jugar con la etiqueta: Lo más importante para mí es intentar ganar un Super Bowl. El receptor George Pickens jugará con los Cowboys esta temporada. Jugará bajo la etiqueta de jugador franquicia, con un valor de 27.3 millones de dólares, para 2026. Se encuentra en el minicampamento obligatorio del equipo para evitar una multa de 107.911 dólares por faltar los tres días, y participará en el campamento de entrenamiento. "Primero es el fútbol americano, ¿entiendes?", dijo Pickens el martes, según Abby Jones de DLLS Sports. "Así que definitivamente jugar al fútbol americano primero, como hice el año pasado, y luego me preocuparé de... bueno, que mi agente se encargue de las negociaciones [del contrato]". Pickens dijo que no participó en el programa voluntario de pretemporada por consejo de su agente, David Mulugheta. El martes insistió en que no está decepcionado de que su contrato a largo plazo no se concrete esta temporada baja. “Lo importante para mí es ganar”, dijo Pickens, según Jon Machota de TheAthletic. “Como dije desde el principio, siempre quiero llevar un Super Bowl a un grupo de jugadores que nunca han experimentado esa sensación. Eso es realmente lo más importante para mí”. #DallasCowboys #GeorgePickens #NFLNews

*receptor. Que no se escribir y después me quiero hacer el filósofo.

This review highlights the lack of dedicated trials and supports an integrated strategy combining alcohol-use management with cardiometabolic therapies, including incretin-based and nuclear receptor–targeting agents. oaepublish.com/articles/mtod… #MetALD #LiverDisease #Pharmacotherapy

GLP-1 Receptor Agonists Slow Epigenetic Aging, a Measure of the Harms Done by Excess Visceral Fat – Fight Aging! fightaging.org/archives/2026…

Por causa do THC, ele age no receptor CB1 q pode alterar a percepção sensorial e bagunçar a percepção dos estimulos, tbm age no hipotalamo que tem também a função de termorregulação do corpo e a ação do THC pode diminuir levemente a temperatura corporal aí dá sensação de frio.

Overall it’s been helpful. Tho does but that opiate receptor. Hence why they had to get rid of it. 🤦

CME INDIA Clinical Pearls (Based on ENDO2026 Presentation) GLP-1RA Users Are Losing Weight But Moving Less: A Wake-Up Call for Obesity Care 1. Weight loss does NOT automatically increase physical activity. A large real-world study presented at ENDO 2026 found that patients with obesity who started GLP-1 receptor agonists became less physically active despite successful weight loss. 2. Daily steps significantly declined. Average daily step count fell from 5,047 to 4,487 steps/day, a reduction of approximately 560 steps/day after GLP-1RA initiation. 3. Exercise intensity also dropped. Moderate-to-vigorous physical activity (MVPA) decreased from 28 to 22 minutes/day, suggesting that patients were not replacing weight loss with increased movement. 4. Men showed the largest decline. Compared with women, men experienced a greater reduction in both daily steps and MVPA. 5. Musculoskeletal pain predicts inactivity. Patients with joint or muscle pain had the greatest reduction in physical activity after starting GLP-1RA therapy. 6. The biggest obesity treatment mistake: Prescribing semaglutide or tirzepatide without an exercise plan. Medication reduces appetite. Exercise preserves muscle. Both are needed. 7. Why this matters clinically. GLP-1-based weight loss includes loss of lean body mass in addition to fat mass. Physical inactivity may further accelerate sarcopenia and functional decline. 8. Every obesity follow-up should include 5 questions: Current step count? Resistance training frequency? Protein intake? Muscle strength? Functional capacity? Do not focus only on kilograms lost. 9. Think beyond the weighing scale. A patient losing 15 kg but becoming weaker is not an ideal obesity outcome. The goal is: Fat loss Muscle preservation Improved fitness Better mobility Long-term health 10. Practical prescription for all GLP-1RA users Protein Resistance Training Walking Weight Loss Medication Not: Weight Loss Medication Alone CME INDIA Bottom Line GLP-1 receptor agonists are powerful weight-loss drugs, but they do not automatically create healthier lifestyles. Patients may lose pounds while simultaneously losing steps, fitness, and muscle. The future of obesity care is not GLP-1RA versus exercise—it is GLP-1RA plus exercise. One-line Clinical Pearl: *"In the GLP-1 era, physicians should monitor step counts as carefully as body weight."* endocrine.org/news-and-advoc… conscienhealth.org/wp-conten…

CME INDIA Clinical Pearls Aberrant GPCRs: A New Frontier in Endocrine Tumours @AskDrShashank (Based on Lancet Diabetes & Endocrinology Review 2024) 1. Endocrine tumours may be driven by “wrong receptors in the wrong place.” Many endocrine tumours express aberrant G-protein coupled receptors (GPCRs) that are normally absent or minimally expressed in that tissue. 2. Hormone excess may occur without classical regulatory pathways. These abnormal receptors allow tumours to respond to unrelated circulating hormones, resulting in autonomous hormone secretion. 3. PBMAH is the prototype disease. Primary Bilateral Macronodular Adrenal Hyperplasia (PBMAH) is the classic example where aberrant GPCR expression drives cortisol hypersecretion. 4. GIP receptor is the most famous example. Some adrenal tumours express GIP receptors (GIPR), causing food-dependent Cushing syndrome, where cortisol rises after meals. 5. GPCR abnormalities extend far beyond adrenal disease. Aberrant receptor expression is now recognized in multiple endocrine neoplasms. Key Tumour-Receptor Associations Primary Aldosteronism Aberrant expression of: MC2R (ACTH receptor) 5-HT4 receptor AVPR1A / AVPR2 LHCG receptor GnRH receptor Clinical implication: Aldosterone secretion may become responsive to non-physiological stimuli. Pheochromocytoma & Paraganglioma Reported aberrant receptors: GCGR LHCGR AVPR1A/AVPR1B 5-HT receptors May contribute to catecholamine excess. Growth Hormone-Secreting Pituitary Adenomas Important receptors: GIPR GnRHR TRHR GPR101 Somatostatin receptors Potential future therapeutic targets. ACTH-Secreting Pituitary Adenomas Aberrant expression of: AVPR1B AVPR2 D2R SSTR5 EGFR May explain differences in response to medical therapies. Medullary Thyroid Carcinoma Relevant receptors: GLP-1 receptor GIP receptor Somatostatin receptors Important for molecular imaging and targeted therapy development. Neuroendocrine Tumours (NETs) Common receptors: Somatostatin receptors GLP-1 receptor GIP receptor Basis for modern receptor-based imaging and radionuclide therapy. Why Should Physicians Care? Functional Imaging Future PET tracers targeting aberrant GPCRs may: Detect occult endocrine tumours Localize hormonally active lesions Improve precision diagnosis Precision Therapy Blocking tumour-specific GPCRs may: Reduce hormone secretion Control tumour growth Offer alternatives to surgery Personalized Endocrinology Tumour receptor profiling may become as important as genetic profiling. What About GLP-1 Receptors? The review highlights GLP-1 receptor expression in: Medullary thyroid carcinoma Neuroendocrine tumours This does not establish that GLP-1 receptor agonists cause these tumours in humans. Current clinical evidence does not support increased MTC risk with GLP-1RA therapy in humans. CME INDIA Take-Home Messages 🔹 Endocrine tumours are increasingly being recognized as receptoropathies, not merely hormone-producing masses. 🔹 Aberrant GPCR expression is a major mechanism behind autonomous hormone secretion. 🔹 PBMAH remains the best clinical model of GPCR-driven endocrine disease. 🔹 GIPR-mediated food-dependent Cushing syndrome is the classic example every endocrinologist should know. 🔹 Future endocrine oncology may move from "Where is the tumour?" to "Which receptor is driving the tumour?" CME INDIA Bottom Line The next revolution in endocrinology may come from receptor profiling. Aberrant GPCRs are emerging as diagnostic markers, imaging targets, and therapeutic opportunities across the spectrum of endocrine tumours. thelancet.com/journals/landi…

En Argentina lo que pasó fue la Reforma. Ya no es el estudiante como receptor sino como protagonista de su proceso de formación. La Reforma nace de una premisa fundamental: el destino heroico de la juventud. Del oscurantismo a la luz de la ciencia. Del dominio colonial a la libertad del continente. De la tiranía a la educación como un acto de amor a los que aprenden.

NEETPG × USMLE 1. Young female ptosis worsens in evening NEET PG Pearl Myasthenia gravis is associated with thymic hyperplasia/thymoma. Anti-ACh receptor antibodies are most common. USMLE Case A 26-year-old woman develops diplopia and ptosis worsening at night. Ice pack test improves symptoms. Diagnosis: Myasthenia Gravis USMLE Testing Point Site: Postsynaptic NMJ Antibody: Anti-ACh receptor Associated tumor: Thymoma Drug worsening symptoms: Aminoglycosides Memory Hook MG = Muscles Get weak with activity. --- 2. Young patient hematuria after sore throat NEET PG Pearl IgA nephropathy presents within days of URTI. USMLE Case 22-year-old man develops cola-colored urine 2 days after pharyngitis. Diagnosis: IgA Nephropathy USMLE Testing Point Mesangial IgA deposition Episodic hematuria Synpharyngitic hematuria Differentiate DiseaseAfter infection IgA nephropathyWithin days PSGN2–4 weeks later --- 3. Child recurrent infections absent thymic shadow NEET PG Pearl 22q11 deletion = DiGeorge syndrome USMLE Case Infant has tetany, recurrent fungal infections, congenital heart disease. Diagnosis: DiGeorge Syndrome USMLE Testing Point Remember: CATCH-22 Cardiac defects Abnormal facies Thymic aplasia Cleft palate Hypocalcemia --- 4. Elderly smoker SIADH NEET PG Pearl Small cell carcinoma causes SIADH, ACTH, Lambert-Eaton. USMLE Case 65-year-old smoker presents with hyponatremia and confusion. Diagnosis: Small Cell Lung Carcinoma USMLE Testing Point Small cell: Central Neuroendocrine markers SIADH ACTH Lambert Eaton NEET favorite: Most common paraneoplastic syndrome → SIADH. --- 5. Hypertension hypokalemia NEET PG Pearl Conn syndrome = Primary hyperaldosteronism USMLE Case 42-year-old woman: HTN Muscle weakness Low renin High aldosterone Diagnosis: Primary Hyperaldosteronism USMLE Testing Point Primary: ↑ Aldosterone ↓ Renin ↑ pH (metabolic alkalosis) ↓ Potassium --- 6. Child abdominal mass crossing midline NEET PG Pearl Neuroblastoma crosses midline. USMLE Case 3-year-old child: Abdominal mass Raccoon eyes Increased urinary VMA Diagnosis: Neuroblastoma USMLE Testing Point Origin: Neural crest Tumor markers: VMA ↑ HVA ↑ Differentiate NeuroblastomaWilms Crosses midlineDoes not VMA ↑WT1 mutation Neural crestKidney --- 7. Chest pain relieved by leaning forward NEET PG Pearl Acute pericarditis USMLE Case Young man develops: Sharp chest pain Better on leaning forward Diffuse ST elevation Diagnosis: Acute Pericarditis USMLE Testing Point ECG: Diffuse ST elevation PR depression Differentiate from MI: MI → regional ST elevation Pericarditis → diffuse ST elevation --- 8. Woman fatigue bronze skin NEET PG Pearl Primary adrenal insufficiency = Addison disease USMLE Case 30-year-old female: Hypotension Hyperpigmentation Hyponatremia Hyperkalemia Diagnosis: Addison Disease USMLE Testing Point Primary: ACTH ↑ Cortisol ↓ Aldosterone ↓ Bronzing occurs because: ACTH → MSH increase --- 9. Sudden severe headache neck stiffness NEET PG Pearl Berry aneurysm rupture → Subarachnoid hemorrhage USMLE Case Patient complains: > "Worst headache of my life." CT: Subarachnoid blood. Diagnosis: Subarachnoid Hemorrhage USMLE Testing Point Associated diseases: ADPKD Ehlers-Danlos Complication: Vasospasm Drug preventing vasospasm: Nimodipine --- 10. Woman galactorrhea bitemporal hemianopia NEET PG Pearl Prolactinoma is the most common pituitary adenoma. USMLE Case 28-year-old female: Amenorrhea Galactorrhea Peripheral vision loss MRI: Pituitary mass. Diagnosis: Prolactinoma USMLE Testing Point Treatment: Cabergoline Bromocriptine Mechanism: D2 agonists ↓ prolactin Visual defect: Bitemporal hemianopia due to optic chiasm compression

when you understand that CB2 receptor on the surface of the white blood cells and how certain forbidden plants can change he surface chemistry it's all over.

#NarcoPresirvientaEspuriaClaudia #MorenaNarcoTerroristas @POTUS @DHSgov @SecRubio @DeputySecState @DAGToddBlanche @SecWar @defense_civil25 @FBI @FBIWFO @FBIMostWanted @DEAHQ @CIA @TomHoman_X @USAmbMex @ofacbase @CBP CUARTO CAPÍTULO "EL ZÓCALO COMO LITURGIA" Pentálogo sobre el pan, el circo y la factura que nadie muestra por José | POSTLANDIA — crónica política sin permiso IV. LA FACTURA QUE CRUZA LA FRONTERA Lo que el IRS, FinCEN y el SAT saben, o deberían saber, sobre quién pagó el concierto. Hay un personaje que no ha aparecido todavía en esta historia y que su ausencia, una vez notada, resulta difícil de ignorar: el contador. No el contador del gobierno mexicano, que firma las partidas presupuestales sin que nadie las audite con independencia real. El contador del artista. El que recibe la transferencia, la registra, calcula la retención, prepara la declaración y —si el artista tiene residencia fiscal en Estados Unidos, si su management opera desde Nueva York o Los Ángeles, si la sociedad que administra sus derechos tiene un EIN registrado ante el IRS— enfrenta un conjunto de obligaciones fiscales y de reporte que el gobierno mexicano no puede suprimir con ninguna reforma constitucional. Porque los artistas cobran. Y los artistas que cobran de gobiernos extranjeros tienen, bajo la ley estadounidense, una cadena de reporte que empieza en el SAT mexicano y termina, si alguien hace su trabajo, en las bases de datos de la Financial Crimes Enforcement Network. El promotor residente en México —en este caso la Secretaría de Cultura de la Ciudad de México, que actúa como contratante— está obligado por la Ley del ISR a retener el 25 por ciento sobre el bruto de los honorarios pagados a artistas residentes en el extranjero, y a enterarlo al SAT a más tardar al día siguiente de realizado el pago, sin deducciones. El contratante está además obligado a emitir CFDI —Comprobante Fiscal Digital por Internet— por cada pago: un documento trazable con folio fiscal único que registra receptor, monto, concepto y fecha. En teoría. Interpol cobró más de 10.4 millones de pesos en honorarios por su actuación del 20 de abril de 2024, más costos operativos que superaron los 11.5 millones. Interpol es una banda formada en Nueva York, con residencia fiscal de sus integrantes distribuida entre Estados Unidos y Reino Unido, que opera a través de estructuras corporativas con presencia en ambas jurisdicciones. El pago que recibió del Gobierno de la Ciudad de México —aproximadamente 520 mil dólares al tipo de cambio de esa fecha— constituye ingreso de fuente extranjera que sus integrantes o su sociedad gestora están obligados a reportar ante el IRS. La forma depende de la estructura: si cobraron como individuos, corresponde el Formulario 1040 con Schedule B para ingresos del exterior y, si los fondos permanecieron en cuentas fuera de Estados Unidos por encima de diez mil dólares, el FinCEN Form 114, conocido como FBAR. Si cobraron a través de una corporación extranjera, corresponde el Form 1120-F. El artista extranjero que recibe compensación por servicios personales está obligado a presentar declaración incluso si el ingreso está exento de tributación, ya que es la única vía para reclamar deducciones, créditos o beneficios de tratados fiscales bilaterales. Aquí es donde la opacidad mexicana choca con la arquitectura de reporte estadounidense, y el choque produce una pregunta que ningún funcionario de la Secretaría de Cultura ha tenido que responder públicamente: ¿el origen de los fondos que se declararon ante el IRS como pago por servicios artísticos puede ser verificado contra la fuente presupuestal del gobierno mexicano que los emitió? La respuesta técnica es: en principio, sí. La respuesta práctica es: solo si alguien lo solicita.

Messi fue receptor de un cambio de frente de Martínez. Termina definiendo un rebote en el área chica. El olfato del gol como marca de nacimiento para Lionel.

The ECM Pharmacology Conference (ECM2026) concludes today in Copenhagen, Denmark. It was great to see Lara Perryman, Senior Research Biologist at Syntara, present "Pan lysyl oxidase inhibitors: dual targeting of collagen cross linking and growth factor receptor oxidation in skin scars and myelofibrosis."   Lara's presentation explored the science behind Syntara's pan-LOX inhibitor programs, including amsulostat in myelofibrosis and myelodysplastic syndrome, and SNT-9465 in skin scarring.   📷 The conference also provided a valuable opportunity to catch up with collaborators and researchers from around the world, including Joan Chang and Professor Thomas Cox. $SNT #ECM2026 #Myelofibrosis #MDS #SkinScarring #DrugDevelopment #Biotech #Fibrosis

those aren’t plastered, they grew via adipose and glandular tissue response to stimulation of the ERα receptor resulting in an ERK/MAPK cascade signaling mitosis and lipid uptake

FYI, there is a medication called prazosin that will get rid of his nightmares. It’s an alpha receptor blocker that’s garbage for treating high blood pressure. It’s really effective for nightmares and I’ve never heard anyone complain about side effects.

Receptor-Mapped Snap cat-receptor protocol / street image

📡 ¿Pagar TV es la única opción? No necesariamente. Con una antena parabólica, un receptor FTA y la configuración correcta puedes captar canales satelitales de señal libre (Free To Air). Descubre cómo funciona. 👇 #TVSatelital #FTA 🔗 tecnobits.net/armar-una-tv-s…