Filter
Exclude
Time range
-
Near
🧠 New in GeroScience! In this review, Hamad Yahia Abu Mhanna and Viktor Vegh examine the MRI brain age gap—the difference between chronological age and predicted brain age—across neurological and psychiatric disorders. Their work highlights the potential of brain age estimation as a biomarker of biological aging and disease-related brain health. Read the article here: rdcu.be/foJ9F #GeroScience #BrainAging #MRI #BiologicalAging #BrainHealth #Neuroscience #AgingResearch
1
5
12
784
🧠💪 New in GeroScience! In their latest study, Shoba Ekambaram & @zoltan_ungvari and colleagues demonstrate that cellular senescence in the brain can drive profound molecular changes in skeletal muscle, revealing a previously underappreciated brain–muscle axis in aging. Using transcriptomic analyses, the authors show that brain senescence induces gene expression patterns in skeletal muscle that resemble those observed in sarcopenia, providing new insights into how aging-related changes in the central nervous system may contribute to age-associated muscle decline. Read the article here: rdcu.be/foJ64 #GeroScience #Sarcopenia #CellularSenescence #BrainAging #MuscleAging #Transcriptomics #HealthyAging #AgingResearch
4
2
233
🧠 How does neuronal mTOR regulate aging-related processes? In a new study, Stacy A. Hussong, Veronica Galvan (@Galvan_Lab) and colleagues investigate the role of neuronal mTOR in regulating survival, growth, and metabolism, shedding light on a key signaling pathway that influences brain function and aging. Read the article: rdcu.be/fn3vg #GeroScience #mTOR #BrainAging #Neuroscience #Metabolism #HealthyAging #AgingResearch
4
6
361
🧠 How does brain glutamate change with age? In a new study, R. Gaudin and colleagues used chemical exchange saturation transfer (CEST) MRI to generate high-resolution glutamate-weighted maps of the mouse brain across the lifespan, providing valuable insights into age-related neurochemical changes in vivo. Read the article: rdcu.be/fnEyd #GeroScience #BrainAging #Neuroscience #MRI #HealthyAging #AgingResearch #Neuroimaging
2
3
293
🥉 Congratulations to Hiroko Isoda (University of Tsukuba, Japan), winner of the Third Prize GeroScience Outstanding Original Research Paper Award! 📖 Award-winning paper: "Transcriptomics and biochemical evidence of trigonelline ameliorating learning and memory decline in the senescence-accelerated mouse prone 8 (SAMP8) model by suppressing proinflammatory cytokines and elevating neurotransmitter release." link.springer.com/article/10… This outstanding research advances our understanding of interventions that may help preserve cognitive function during aging. #GeroScience #AgingResearch #BrainAging #CognitiveHealth #HealthyAging #AGE2026
3
6
365
🧠🔬 How do microglia change with age across species? A new study by Laura M. Carr and colleagues characterizes age-related changes in microglial morphology and proliferation across multiple species. The findings highlight conserved patterns of microglial remodeling during aging, offering important insight into neuroinflammation and brain aging biology. 🔓 Read more: rdcu.be/fjqtD #Aging #Microglia #Neuroscience #BrainAging #Geroscience
3
4
288
🩸 Tiny brain bleeds may signal a brain that is aging faster than expected. In a new neuroimaging study, Raghav Pallapothu and colleagues found that stroke patients with infratentorial cerebral microbleeds had a greater “brain age gap” — meaning their brains appeared biologically older on MRI scans. The findings strengthen the connection between vascular injury, accelerated brain aging, and neurodegeneration, and highlight the potential of brain-age biomarkers in stroke research. #Stroke #BrainHealth #BrainAging #Neuroimaging #Geroscience
3
8
527
🧠 AI Reveals MRI Signatures of Brain Aging and Neurodegeneration A new study by Nikhil N. Chaudhari and colleagues used interpretable deep learning to identify MRI patterns linked to brain aging and neurodegeneration. 📌 The model detected spatiotemporal brain changes associated with aging 📌 Identified MRI features aligned with neurodegenerative processes 📌 Findings may improve early detection and understanding of brain aging trajectories 💡 Combining AI with brain imaging could help uncover biomarkers of aging and neurodegenerative disease progression. #BrainAging #AI #Neuroscience #Alzheimers #Geroscienc
2
3
275
Are everyday environmental toxins accelerating how we age? Session 2 at #AGE2026 tackles Environmental Toxin Exposures & Aging Mechanisms — chaired by Michael Stout (@OMRF). Register → bit.ly/4vDrGxG #Phthalates #Nanoplastics #brainAging #MitochondrialDynamics
2
2
365
🧠 How Aging May Increase Vulnerability to Parkinson’s Disease A new study by Jiaqi Wen examines how aging affects the nigrostriatal system — a key brain pathway involved in movement and Parkinson’s disease. 🔬 Researchers found age-related changes in: • Brain structure • Blood flow dynamics • Neural connectivity within the nigrostriatal pathway 💡 These findings help explain how normal aging may create conditions that increase susceptibility to Parkinson’s disease and related neurodegenerative processes. #Parkinsons #Neuroscience #BrainAging #Geroscience
3
5
398
A New Study in 495 Centenarians Points to a Brain Aging Biomarker You Probably Have Not Heard Of Most people know about blood pressure for heart disease and blood sugar for diabetes. Far fewer know that there's now a blood biomarker quietly building a case as one of the more informative readouts for brain aging. A new JAMA Network Open paper followed 495 Japanese centenarians for 17 years. NfL (neurofilament light) predicted both cognition and lifespan more reliably than the classical Alzheimer's-specific markers did in this cohort. 🧬 NfL is released into blood when axons get damaged from any cause, including aging, stroke, MS flares, concussion, and neurodegeneration 📊 Each 1 SD higher NfL meant 36% higher mortality, even after adjusting for kidney function and APOE4 🧠 Phosphorylated tau did not predict mortality after full adjustment in this cohort. Only NfL did. 💉 Plasma NfL tests now run $200-400 at Labcorp, Quest, and several direct-to-consumer services This does not replace amyloid and tau testing. It adds a different lens. Plaques and tangles are part of the story, but aging, vascular wear, and injury also drive cognitive trajectories, and NfL captures those. This is why brain aging assessment is moving toward multimodal panels that combine NfL with imaging and genetics, each catching what the others miss. Link to full post: drglorioso.substack.com/p/a-… #BrainAging #Longevity #BrainHealth
8
14
833
Aging-US is proud to sponsor the Neuroscience of Vitality and Aging (NOVA) Conference, taking place Saturday, April 25 in Boston, MA. Exploring the future of brain health and aging. Learn more ⬇️ novaneuro.org/ #Aging #Neuroscience #BrainAging #Longevity #Research
1
2
85
Join us at the Neuroscience of Vitality and Aging Conference for “Studying the Biology of Brain Aging with New Tools”, a panel discussion featuring Jiang He, Co-founder & VP of Reagents at Vizgen. 📅 April 25 | 🕥 10:30–11:30 AM (panel audience Q&A) 📍 David Rubenstein Treehouse at Harvard University @vizgen_inc is proud to sponsor this meeting. Stop by our booth to learn about our newly launched Pre-designed Brain Panels for human and mouse, now with Add-on capabilities to extend your discoveries in spatial biology. #NOVA2025 #BrainAging #Neuroscience #SpatialBiology #Vizgen
1
2
225
⭐️April is #GraduateStudentAppreciation Month!👩🏻‍🎓 SUPER EXCITED to highlight the @ZhenyuYue_ Lab’s @MariannaLiang! A 5th year PhD Candidate, Marianna is dedicated to advancing our understanding of #BrainAging, aging-related #NeurodegenerativeDisorders & #Healthspan extension.👏
1
3
154
Aging-US is proud to sponsor the Neuroscience of Vitality and Aging (NOVA) Conference, taking place Saturday, April 25 in Boston, MA. Exploring the future of brain health and aging. Learn more ⬇️ novaneuro.org/ #Aging #Neuroscience #BrainAging #Longevity #Research

2
2
106