#Integratedfarming transforms food systems by replacing conventional single-crop methods with a harmonized, multi-enterprise approach. Read the article: africafarmingjournal.org/int… #foodsecurity #foodsystems #nutrition #smallholderfarmers #closedloopsystems #kenya

Learn and Grow Blog... The 5 Questions Every Lab Director Asks Before Going Closed‑Loop... Continue reading it here... zurl.co/Yd9Nh #Agappe #LearnAndGrow #LabAutomation #ClosedLoopSystems #LabLeadership #SmartLaboratories

Bioelectronics & Precision Neuromodulation: The Next Therapeutic Frontier What if we could treat disease not with drugs…but with electricity? ⚡️ Imagine an implantable device that senses disease in real time - and responds instantly. No waiting. No systemic side effects. Just closed-loop, precision therapy powered by your own neural circuits. In our latest episode of @ProgressPotent1, I spoke with Dr. Robert Spoelgen, VP and Head of Bioelectronics at @merckgroup @merck_de He’s leading one of pharma’s boldest “beyond the pill” bets: Selective peripheral nerve stimulation Real-time, data-driven therapeutic systems All aimed at tackling chronic diseases like hypertension and inflammation. What makes this especially compelling is his journey - from molecular neuroscience (PhD at the @MDC_Berlin and postdoc at @harvardmed) to building programmable, device-based therapies. We explore: • The shift from pharmaceuticals → electroceuticals; • Why precision neuromodulation could redefine chronic disease treatment; • How bioelectronics may actually accelerate drug discovery; • Merck KGaA, Darmstadt, Germany’s strategy at the intersection of neuroscience, AI, and medtech; This is a fascinating look at a future where biology is not just treated - but programmed. #Bioelectronics #VagusNerve #Neurostimulation #FutureOfMedicine #PrecisionMedicine #DigitalHealth #Neuroscience #MedTech #HealthcareInnovation #Pharma #Neurotechnology #Electroceuticals #ClosedLoopSystems #ChronicDisease

Bioelectronics & Precision Neuromodulation: The Next Therapeutic Frontier What if we could treat disease not with drugs…but with electricity? ⚡️ Imagine an implantable device that senses disease in real time - and responds instantly. No waiting. No systemic side effects. Just closed-loop, precision therapy powered by your own neural circuits. In our latest episode of @ProgressPotent1 , I spoke with Dr. Robert Spoelgen, VP and Head of Bioelectronics at @merckgroup @merck_de . He’s leading one of pharma’s boldest “beyond the pill” bets: ➡️ Selective peripheral nerve stimulation ➡️ Advanced vagus nerve modulation ➡️ Real-time, data-driven therapeutic systems All aimed at tackling chronic diseases like hypertension and inflammation. What makes this especially compelling is his journey - from molecular neuroscience (PhD at the @MDC_Berlin and postdoc at @harvardmed) to building programmable, device-based therapies. We explore: • The shift from pharmaceuticals → electroceuticals; • Why precision neuromodulation could redefine chronic disease treatment; • How bioelectronics may actually accelerate drug discovery; • Merck KGaA, Darmstadt, Germany’s strategy at the intersection of neuroscience, AI, and medtech; This is a fascinating look at a future where biology is not just treated - but programmed. Watch here: youtube.com/watch?v=zdQu9prX… Curious to hear your take: Will electroceuticals replace drugs - or become a powerful complement #Bioelectronics #VagusNerve #Neurostimulation #FutureOfMedicine #PrecisionMedicine #DigitalHealth #Neuroscience #MedTech #HealthcareInnovation #Pharma #Neurotechnology #Electroceuticals #ClosedLoopSystems #ChronicDisease

Azolla The Floating Protein Plant Azolla is one of the most remarkable plants used in regenerative agriculture. This tiny floating fern grows on the surface of still or slow-moving water and forms dense green carpets across ponds and wetlands. What makes Azolla extraordinary is its symbiotic partnership with a nitrogen-fixing cyanobacteria (Anabaena azollae) living inside its leaves. This microscopic partner converts atmospheric nitrogen into plant nutrients. In simple terms: Azolla makes its own fertilizer. Because of this relationship, Azolla can double its biomass in 2–5 days under good conditions. A Natural Protein Source Azolla contains 20–35% protein (dry weight) and is rich in: • amino acids • iron • calcium • beta carotene • vitamins A and B For this reason it is widely used as livestock and poultry feed across Asia and increasingly in regenerative farms worldwide. Animals that commonly eat Azolla include: • chickens • ducks • fish • pigs • rabbits • cattle For chickens, Azolla can replace 15–25% of commercial feed while maintaining egg production. For fish and ducks, it can sometimes replace 30–40% of feed inputs. It becomes a living protein generator growing directly from sunlight and water. Why Azolla is Powerful Azolla performs several ecological roles at once. It acts as: • nitrogen fertilizer • animal feed • weed suppression • water cooling cover • mosquito control (blocks breeding surfaces) • carbon capture plant In rice systems, farmers have used Azolla for centuries to fertilize fields naturally. The plant spreads across the water, fixes nitrogen, and when incorporated into the soil becomes green manure. Other Regenerative Protein Sources Azolla is not alone. Several biological systems convert sunlight and waste nutrients into protein extremely efficiently. Duckweed (Lemna) Duckweed is the fastest growing plant on Earth. It can double biomass in 24–48 hours. Protein content: 20–40%. It is widely used as feed for fish, chickens, and pigs. Black Soldier Fly Larvae These insects convert organic waste into high-protein feed. Protein content: 40–60%. They can process food scraps, manure, and agricultural waste while producing nutrient-rich compost. Comfrey Comfrey leaves contain significant protein and minerals and can supplement feed for chickens, rabbits, and livestock while also building soil fertility. The Regenerative Protein Loop When combined, these organisms create an extremely efficient nutrient cycle. Sunlight feeds plants. Plants feed animals. Animals produce nutrients that feed plants again. A simple loop might look like this: Azolla Duckweed → Chickens / Fish Kitchen scraps → Black soldier fly larvae → Chickens Comfrey → supplemental greens → Chickens Chicken manure → compost → soil fertility → plant growth Very little leaves the system. Waste becomes food. Food becomes fertility. In living agricultural systems, plants and animals are not separate industries. They are organs within one ecosystem. Azolla floating on water. Comfrey pulling minerals from deep soil. Duckweed multiplying in ponds. Each one quietly converting sunlight into food. Life is infrastructure. Water circulates. The Ark breathes. Dawn Littlefield First Keeper of the Rose-Gold Sky The Ark Initiative Creation has a few tricks up her sleeve. #Azolla #Duckweed #RegenerativeAgriculture #AlternativeProtein #Permaculture #ClosedLoopSystems #LivingInfrastructure #ArkInitiative

Floating Gardens on a Living Ship Floating Swales and Toroidal Veins in a Biomechanical Civilization In the Ark Initiative- a 40,000-acre living organism engineered as a prototype for non-domination civilization we did not build a structure and then add gardens. We built a body. Petals flex. Ribs rotate. Fascia yields. The organism breathes. And within that motion gardens float. Not metaphorically. Mechanically. Floating Swales Traditional permaculture assumes still ground. Swales are carved into earth. Water rests in gravity wells. But this system moves. It bends. It contracts. It unfurls. It shifts ballast. So we did not dig trenches. We embedded infiltration bands inside rib-mounted, flex-balanced cassettes aligned with the neutral axis the protected still band of each petal. Water does not collect in exposed slopes. It diffuses through: • biochar strata • pumice layers • mycelial reinforcement • embedded ollas acting as capillaries These swales absorb, buffer, and release without shear, slosh, or root tear. Hydrology becomes tissue. Toroidal Veins Delta carries water through closed loops- toroidal basins and braided return channels. There are no dead ends. Every basin feeds a return path. Every overflow reconnects to trunk arteries. When motion occurs: • laminar baffles damp turbulence • ballast shifts redistribute mass • capillary shelves soften wave faces Surface disturbance remains below biological alarm thresholds. Ducks continue foraging. Koi remain laminar. Lotus leaves stay still. Water circulates like blood. Neutral Axis Living The structure may shift. The inhabited world does not register disruption. Flex happens in ribs and connective fascia. Life rides the still band. Soft gimbal cradles auto-level. Soma ballast shifts passively. Tilt rates remain below vestibular alarm thresholds. No sudden snaps. No forced correction. Yield before fracture. Distribution over concentration. Ollas as Capillaries Beside each tree and row sit unglazed clay vessels- ollas. Moisture seeps through porous walls according to soil tension. Roots pull. Release adjusts. No pumps. No evaporation loss. No runoff. When the petal articulates, each olla remains seated in a flex collar cradle. Moisture continuity is preserved. The root zone remains stable. Ancient intelligence integrated into adaptive architecture. Swales Within a Body These swales do more than harvest water. They: • buffer humidity shifts • stabilize soil temperature • dampen vibration • distribute nutrients • support amphibian habitat • maintain microbial coherence They are not landscape features. They are organs. Biological Validation Engineering is confirmed by life. If: • ducks do not startle • geese do not alarm • koi remain laminar • bees continue working • frogs keep calling at dusk Then the system is coherent. Stillness is measurable. After Fortress Thinking Rigid systems resist until they fracture. Organisms survive by distributing stress. This is not defensive architecture. It is responsive ecology. Floating gardens. Floating swales. Toroidal veins. When the storm arrives, the structure yields. Inside, someone sits beside a lotus basin. The air cools slightly. That is the only sign. Life is infrastructure. Water circulates. The Ark breathes. Motion outside. Stillness inside. Dawn Littlefield First Keeper of the Rose-Gold Sky The Ark Initiative Creation has a few tricks up her sleeve yet.😎 #FloatingGardens #LivingShip #FloatingSwales #ToroidalVeins #RegenerativeDesign #BiomechanicalArchitecture #PermacultureDesign #WaterIsLife #ClosedLoopSystems #ClimateResilience #LivingInfrastructure #ArkInitiative #EcologicalDesign #Biomimicry #CircularSystems

♻️ If your business enables circularity, this is where demand finds you. The circular economy needs more than intent- it needs recyclers, compounders, material recovery systems, and proven technologies. RACE is built for companies that convert waste into value and sustainability into supply. 📌 Why exhibit at RACE 2026? * Meet high-intent buyers actively sourcing solutions * Position your brand at the centre of circular plastics * Showcase live technology, materials, and processes * Build credibility in a compliance-driven market ⚙️ RACE connects exhibitors directly with manufacturers, converters, brand owners, and policymakers preparing for a circular future. 🔗 Exhibit where decisions begin. Enquire now for RACE 2026: shorturl.at/AAoqp Brought to you by: @POLYMERUPDATE Proudly Supported by: @MyBmc Association Partners: @spe_india10, Organisation of Plastics Processors Of India, Material Recycling Association Of India (@mrai_india), SME Chamber of India (@smechamber), Plastics Machinery Manufacturers Association of India, Indian Plastics Institute. Environment Partner: @MissionMGM Media Partners: Plastics Recycling World, Compounding World Knowledge Partner (Harit Bharat - School Action Zone): @icpemumbai #Polymerupdate #RACE2026 #RACEtoRecycle #Ewaste #Rubber #Textiles #RecyclingIndustry #PlasticsRecycling #CompoundingSolutions #CircularEconomy #PlasticsRecycling #B2BInnovation #SustainableManufacturing #ClosedLoopSystems #RecyclingAndCompoundingExpos #NESCO #MumbaiExpo2026

♻️ The circular economy isn't a theory anymore. It's an operating reality. 🏭 If you work with plastics, sustainability, waste management, or manufacturing, the shift from a linear to a circular economy directly affects your decisions. RACE brings together recyclers, compounders, and technology providers actively building closed-loop plastic systems at an industrial scale 🌟 Why visit RACE 2026? * See real recycling & compounding technologies in action * Understand how circular plastics systems actually work * Meet solution providers, not slide decks * Learn how industry is preparing for compliance & traceability This is where India's circular plastics ecosystem comes together—practically, commercially, and credibly. Visitor registrations are live. Experience circularity at Recycling And Compounding Expo 2026. Join RACE: Recycling & Compounding Expo 2026 🗓 6–8 May 2026 📍 Hall 4, NESCO, Mumbai, India 📩 Enquire now: shorturl.at/3ynAX Brought to you by: Polymerupdate Proudly Supported by: MyBmc Association Partners: Society of Plastics Engineers India - SPE India, Organization Of Plastics Processors Of India, Material Recycling Association Of India, SME Chamber of India, Plastics Machinery Manufacturers Association of India, Indian Plastics Institute Environment Partner: Mission Green Mumbai Media Partners: Plastics Recycling World, Compounding World Knowledge Partner (Harit Bharat - School Action Zone): Indian Centre for Plastics in the Environment #Polymerupdate #RACE2026 #RACEtoRecycle #Ewaste #Rubber #Textiles #RecyclingIndustry #PlasticsRecycling #CompoundingSolutions #CircularEconomy #PlasticsRecycling #B2BInnovation #SustainableManufacturing #ClosedLoopSystems #RecyclingAndCompoundingExpos #NESCO #MumbaiExpo2026

📢 RACE 2026: Where Recycling Meets Real Industry Demand As industries accelerate recycling, circular materials, and performance-driven manufacturing, solution providers need more than visibility- they need qualified buyers, real conversations, and long-term relevance. RACE 2026: Recycling And Compounding Expo is designed for companies delivering 🔹 Recycling & material recovery technologies 🔹 Compounding, masterbatches & additives 🔹 Sustainable and circular material solutions 🔹 High-performance polymer innovations RACE connects you directly with brands, converters, manufacturers, and decision-makers actively seeking scalable, future-ready solutions. Exhibit to showcase expertise, build authority, and position your brand at the core of India's recycling and circular economy ecosystem. 📍Join RACE: Recycling & Compounding Expo 2026 🗓 6–8 May 2026, Hall 4, NESCO, Mumbai, India 🔗 Book your space: shorturl.at/24ATW Brought to you by: @POLYMERUPDATE Proudly Supported by: @MyBmc Association Partners: Society of Plastics Engineers India - SPE India, Organization Of Plastics Processors Of India, Material Recycling Association Of India, SME Chamber of India, Plastics Machinery Manufacturers Association of India, Indian Plastics Institute. Environment Partner: Mission Green Mumbai Media Partners: Plastics Recycling World, Compounding World Knowledge Partner (Harit Bharat - School Action Zone): Indian Centre for Plastics in the Environment #Polymerupdate #RACE2026 #RACEtoRecycle #Ewaste #Rubber #Textiles #RecyclingIndustry #PlasticsRecycling #CompoundingSolutions #CircularEconomy #PlasticsRecycling #B2BInnovation #SustainableManufacturing #ClosedLoopSystems #RecyclingAndCompoundingExpos #NESCO #MumbaiExpo2026

what remains stable when motion, time, and matter changebut reference frames do not. #SystemsThinking #noline #Observation #EmbodiedCognition #ClosedLoopSystems #buildforanyneeds #ExperimentalVisualization #システム思考 #観察 #身体性 #知覚 #時間

Toward Fully Autonomous Closed-Loop Molecular Discovery – A Case Study on JAK Targets 1. Researchers have introduced the first fully automated, closed-loop molecular discovery cycle, focusing on identifying novel JAK inhibitors. This work bridges AI and self-driving laboratories, minimizing human intervention and integrating AI-driven molecular design, automated synthesis, and in-vitro screening. 2. The study performed two Design-Make-Test-Analyze (DMTA) cycles, synthesizing a total of 36 compounds. In the first round, the AI model identified structural analogs of known JAK inhibitors without being explicitly trained on them, demonstrating its ability to explore chemical space creatively. 3. The second iteration of the cycle yielded molecules with significantly improved pIC50 and ligand efficiency compared to the first round (p < 0.001), highlighting the effectiveness of the closed-loop workflow and its potential for iterative optimization in drug discovery. 4. The framework leverages IBM's RoboRXN for automated synthesis and Arctoris' Ulysses platform for automated in-vitro screening, showcasing the integration of advanced technologies to accelerate molecular discovery. This approach could have significant implications for reducing costs and speeding up the development of new drugs. 5. The study demonstrates that each iteration of the DMTA cycle can be incorporated into the next, improving the generation process and results. This iterative improvement is crucial for refining molecules and enhancing their binding affinity to JAK targets. 📜Paper: doi.org/10.26434/chemrxiv-20… #MolecularDiscovery #AIinChemistry #AutomatedLaboratories #JAKInhibitors #DrugDiscovery #ClosedLoopSystems

Just stop evaporating trillions of gallons of water vapor a day #duh #closedloopsystems

#ClosedLoopSystems, however, centralize control and restrict access. Their opacity makes interoperability complex and expensive, forcing dependence on proprietary platforms and stifling innovation. This dependency weakens domestic capacity and threatens national #DigitalAutonomy.

I harvested these on Mark Shepard’s farm not too long ago. No one inoculated this log or tends it. It’s a fallen tree in a well-designed system where biology capitalizes on stored energy: wood to fungi, fungi to soil, soil to future growth. That’s compounding without oversight. Restoration Agriculture’s quiet superpower: you don’t fight nature for yield; you create conditions where yield is inevitable. Build the structure once, and the ecosystem works indefinitely. Design nature to thrive, and she will produce an abundance you couldn’t imagine. Bitcoin applies the same intelligence to money. No nagging, managing, or bribing with policy, just fix the base layer to prevent leakage, and the system compounds by design. Not because people behave better, but because the rules make waste unaffordable. People mistake effort for mastery. True mastery builds systems that produce long after you stop intervening. Forests do this in biology; Bitcoin does it in value. #TBSI #Permaculture #Bitcoin #ClosedLoopSystems

RWD Olfactometer Updated: Unlocking New Possibilities for Neuroscience Research linkedin.com/pulse/rwd-olfac… Redesigned for Precision. Built for Neuroscience. The upgraded RWD Olfactometer enables precise TTL outputs for every odor, behavioral result, and trial phase—allowing effortless synchronization with fiber photometry, electrophysiology, optogenetics, and other third-party systems. No more manual tagging or data alignment. Just cleaner signals, automated feedback, and faster insight into neural-signal-behavior relationships. Learn more: rwdstco.com/product-item/rwd… #NeuroscienceResearch #BehavioralNeuroscience #Olfactometer #FiberPhotometry #Optogenetics #ClosedLoopSystems #LabAutomation

💧🚫 Every Drop Counts — Refining Without Wastewater Water sustainability is no longer optional — it’s operational. With Zero Liquid Discharge (ZLD), Techinergy is setting new environmental standards: 🔹 Treats and recycles all wastewater from refinery processes 🔹 Uses multi-effect evaporation, RO membranes, and crystallizers 🔹 Delivers 100% wastewater recovery, zero discharge 🔹 Compliant with the strictest global environmental norms A closed loop. A cleaner refinery. A greener future. #Techinergy #ExcellenceDrivingTheFuture #News #SocialMedia #India #World #Business #Technology #Innovation #Petroleum #Petrochemical #oil #crudeoil #energy #marketing #Biofuel #environment #Sustainability #US #UK #lubricants #bitumen #ZeroLiquidDischarge #WaterRecovery #ZLD #RefineryWaterTreatment #EcoRefinery #CleanWaterTech #ClosedLoopSystems #WastewaterRecycling #refinery @IndianOilcl @HPCL @BPCLimited @Shell @TotalEnergies @MarathonOil @NayaraEnergy

Cracking the Case: Diagnosing Overheating in a Closed-Loop Hydraulic System #HydraulicTroubleshooting #ClosedLoopSystems #Electrohydraulics #FluidPowerDiagnostics #IndustrialMaintenance #CasePressureReplenishing #PumpCavitationSolutions fluidpowerjournal.com/an-ove…

Iceland’s industries are adopting closed-loop systems, where waste from one process becomes input for another, ensuring that resources are kept in circulation. #ClosedLoopSystems #IcelandInnovation

Iceland is focusing on creating closed-loop systems in industry, where waste materials are repurposed and reintegrated into the production process. #ClosedLoopSystems #IcelandTech

Iceland is fostering the growth of a circular economy by encouraging industries to create closed-loop systems, where waste products are turned into valuable resources. #ClosedLoopSystems #IcelandTech