I'm too tired to tell this fucking idiot why he's dead wrong but he is. Former medical cannabis caregiver, patient advocate, endocannabinoid and phytocannabinoid science clinical consultant and the best independent producer of Rick Simpson oil in the country but wtf do I know

"Identification of #cannabichromevarin as a potent stabilizer of the measles virus prefusion F protein: structural insights from long-timescale molecular dynamics" pubmed.ncbi.nlm.nih.gov/4228… “#CBCV is a #phytocannabinoid found naturally in #cannabis" thctotalhealthcare.com/

#WorldSchizophreniaAwarenessDay #Schizophrenia 🧠🗣️For over a century Schizophrenia has been largely been framed as a "dopamine disorder". That model may now be collapsing. One of the most revolutionary developments in modern psychiatry is the growing evidence that Schizophrenia may involve: ➡️Immune dysregulation ➡️Chronic inflammation ➡️Autoimmune mechanisms ➡️Abnormal synaptic pruning ➡️Developmental injury to the brain ➡️Gut-brain dysfunction This is not fringe science anymore. It is becoming main-stream neuroscience. 📑Researchers are increasingly asking a profound question: What if Schizophrenia is not simply a chemical imbalance but in some cases, a disorder of the immune system interacting with the developing brain? The implications are enormous. 📑Studies now show links between Schizophrenia risk and: ➡️Maternal infection or immune activation during pregnancy ➡️Chronic system inflammation ➡️Autoimmune disorders ➡️Altered gut microbiome composition ➡️Excessive activation of microglia - the brain's immune cells ➡️Abnormal "synaptic pruning" during adolescence 🧠Synaptic pruning may be one of the biggest breakthroughs of all. During adolescence, the brain naturally removes unused neural connections. But emerging evidence suggests some people with Schizophrenia may undergo excessive pruning - literally losing too many neural connections at a critical developmental stage. 👉That could help explain: ➡️Why Schizophrenia often emerges in the teens and twenties ➡️Cognitive decline ➡️Dysconnectivity in the brain networks ➡️Hallucinations and altered perception Even more fascinating is the emerging relationship between the Endocannabinoid System and the gut microbiome. Gut bacteria may influence Endocannabinoid tone. The Endocannabinoid System may influence gut permeability and inflammation and together they may shape immune activity, mood, cognition and brain development. 👉In other words: The gut, immune system, brain, microbiome and Endocannabinoid System may all be communicating continuously in ways psychiatry only recently began to understand. ▶️This is a profound shift in scientific thinking. 🪩The future of psychiatry may not just involve neurotransmitters. It may involve: ➡️Immunology ➡️Inflammation science ➡️Microbiome medicine ➡️Neurodevelopment ➡️Metabolic health ➡️Systems biology And compounds capable of regulating neuroinflammation and neural plasticity through the Endocannabinoid System. 🪩We are witnessing the beginning of a paradigm shift. And psychiatry may never look the same again. 🧠And it may eventually change how we think about mental illness itself. And this is precisely why cannabinoids are now attracting serious attention in neuroscience and psychiatric research. ▶️Not because researchers believe 🌱Cannabis "cures" Schizophrenia - in fact, high THC exposure is associated with increased psychosis risk in certain vulnerable individuals - but because certain cannabinoids appear to interact with many of the exact systems now implicated in psychiatric disease. Researchers are studying cannabinoids because of their influence on: ✅ Immune signalling ✅Neuroinflammatory pathways ✅Oxidative stress ✅Neurotransmitter regulation ✅Microglial activation ✅Gut microbiome interactions ✅Microbial metabolites ✅Neural plasticity ✅The Endocannabinoid System - one of the body's master regulatory networks The Endocannabinoid System is deeply involved in maintaining biological balance across the brain, immune system, gut, metabolism, stress response and nervous system. And dysfunction within this system is increasingly being linked to: ➡️Psychosis ➡️Mood disorders ➡️Anxiety ➡️Neurodevelopmental disorders ➡️Inflammatory disease 🪩This is why compounds such as CBD, CBG, THCV and CBDV are now being explored in preclinical and early psychiatric research. Scientists are particularly interested in whether some cannabinoids may help regulate: ➡️Excessive inflammatory signalling ➡️Glutamate and dopamine imbalance ➡️Stress-system over-activation ➡️Immune dysfunction ➡️Impaired connectivity between brain networks And then there's the gut-brain axis. 🪩🗣️This may become of the defining discoveries in future psychiatry. The gut is not just involved in digestion. It communicates continuously with the brain through: ➡️Immune signalling ➡️Inflammatory pathways ➡️Neurotransmitter production ➡️The Vagus Nerve ➡️Microbial metabolites ⚠️Modern living may be profoundly disrupting this system. Consider what has changed dramatically in the last century: 🔍Ultra-processed diets 🔍Reduced microbial diversity 🔍Antibiotic overuse 🔍Chronic stress exposure 🔍Sleep disruption 🔍Sedentary indoor lifestyles 🔍Environmental toxins 🔍Social isolation 🔍Urbanisation 🔍Chronic low-grade inflammation ⚠️We are now living in the most biologically unnatural environment in human history. 🧠▶️Could this help explain why severe mental health disorders appear increasingly common and increasingly inflammatory? No serious scientist would claim Schizophrenia is caused by one entity alone. Genetics clearly matter. Development matters. Trauma matters. But the emerging picture is far more interconnected than psychiatry once believed. 🧠The brain may not be malfunctioning in isolation, it may be responding to immune, inflammatory, microbial and environmental pressures accumulated across a lifetime - beginning even before birth. This new model changes everything. ➡️It changes how we think about prevention. ➡️It changes how we think about treatment. Sources: "The Endocannabinoid as a Substrate for Non-euphoric Phytocannabinoid Action and Gut Microbiome Dysfunction in Neuropsychiatric Disorders" - Vincenzo di Marzo - Dialogues in Clinical Neuroscience *Vincenzo di Marzo is one of the leading cannabinoid researchers and has over 120,000 citations. He is widely regarded as a foundational figure in Endocannabinoid science. "Targeting Neuroinflammation in Schizophrenia: A Comprehensive Review" - Asian Journal of Psychiatry/Science Direct "Neuroinflammation in Schizophrenia: An Overview of Evidence and Therapeutic Perspectives" - Journal of Integrative Neuroscience "The Gut-Brain Axis in Schizophrenia: A Systems-Level Perspective" - MDPI Applied Microbiology "The Gut-Brain Axis in Depression, Anxiety and Schizophrenia" - Annals of General Psychiatry academic.oup.com "Integrated Analysis of Gut Microbiome, Inflammation and Neuroimaging Features Supports the Role of Microbiome-Gut-Brain Crosstalk in Schizophrenia". JOIN US/CONTACT US: info@kencannagence.com #transformtoprosper #evolveorrepeat #GutBrainAxis @NAMICommunicate @TheSADAG @SIRSGlobal @ABHNetwork @npp_journal @FrontPsychiatry @JAMA_current @PsychiatricNews @NextScience @Newsforce @Stats_Kenya @PSofKenya @Amref_Kenya @Mideaminds @AKUMCEA @afrimeb_kenya @PsychTimes @globalcdp @MOHmentalhealth @Dr_chitayi @KPAkenya @Euro_Psychiatry Image: Central Institute of Mental Health, Mannheim, Molecular Psychiatry

Withdrawal doesn’t just leave someone missing a drug; it leaves the body and brain struggling to find rhythm again. In “Cannabidiol for the Reduction of Cue-Induced Craving and Anxiety in Drug-Abstinent Individuals With Heroin Use Disorder: A Double-Blind Randomized Placebo-Controlled Trial” (2019), Yasmin Hurd and colleagues looked at whether CBD, a nonintoxicating phytocannabinoid, could help steady that imbalance in abstinent individuals with heroin use disorder. What makes this study matter is that it did not chase a vague wellness claim. It targeted two of the hardest parts of recovery - craving and anxiety triggered by drug cues, the very signals that can pull someone right back toward relapse. The trial found that short-term CBD treatment reduced cue-induced craving and anxiety compared with placebo, and it also lowered some of the physical stress responses tied to those triggers, including heart rate and salivary cortisol. Even more interesting, those effects persisted for up to 7 days after the last CBD administration. That’s where phytocannabinoids start looking less like a side note and more like a regulatory tool. When withdrawal has left stress circuitry overactive and reward circuitry out of step, a compound like CBD may help calm the alarm system without creating the same intoxicating pull. It is not a magic fix, and this study was specific to heroin cue reactivity, not every form of addiction, but it gives real evidence that a plant cannabinoid can help restore functional balance during recovery by reducing the biological and emotional signals that keep addiction cycling. -Mike Robinson, The Researcher OG #CannabisHeals Study Link: psychiatryonline.org/doi/10.…

Exploring Biological Activity of Phytocannabinoid Formulations for Skin Health Care This study confirms safety & efficacy of phytocannabinoid-based formulations for skin applications, highlighting potential to enhance regeneration & structural processes. pmc.ncbi.nlm.nih.gov/article…

Phytocannabinoid Enriched Hemp Seed Oil, made in my refrigerator for my own health. I highly recommend you look into balancing your two essential fatty acids Omega-6 and your Omega-3 by consuming nature’s most perfectly balanced oil, which happens to be Hempseed oil. The article I wrote on my website which talks about the oil I make for myself is on my site agseedco.com I personally mix my oil (10 g BHO or Rosen dissolved into 20 ounces of hemp seed oil) on top of a little bit of orange juice or pineapple juice so that I don’t taste the oil. Try it yourself and get a little bit more healthy every day! ☮️

Behind every Cayman CRM is a process built on quality, precision, and care. We’ve updated our pricing on 80 Phytocannabinoid CRMs so you can get more value from the high‑quality certified reference materials you rely on. Save now on our full Phytocannabinoid CRM collection, including mixtures and single component standards: loom.ly/TszKenM #CertifiedReferenceMaterials #LCMS

Neurologist Ethan Russo has stated that cannab*s is one of the most chemically complex medicinal plants studied in modern science. According to Dr. Russo, the plant contains a wide range of biologically active compounds that interact with the body’s internal regulatory systems. Academic sources indicate that beyond primary cannabinoids, cannab*s also includes terpenes, flavonoids, and other naturally occurring molecules. Studies suggest these compounds may work together in what researchers call a combined or synergistic effect, meaning their influence may differ when present as a full spectrum rather than in isolated form. In a 2011 paper published in the British Journal of Pharmacology, Dr. Russo discussed how disruption in the body’s endocannabinoid system may play a role in certain difficult to manage conditions such as migraine and fibromyalgia. Researchers emphasize that continued scientific studies are required to better understand these mechanisms. Importantly, Dr. Russo has consistently argued that cannab*s should be approached as a regulated medical subject requiring careful research, structured dosing, and professional oversight. ➡️ Note: This content is shared for academic interest, based on scientific studies and historical records. It does not promote, sell, or encourage recreational or non-medical substance use. Source: Russo, Ethan B. “Taming THC: Potential cannabis synergy and phytocannabinoid-terpenoid entourage effects.” #fblifestyle #PKR #USA #CannabisResearch #NeuroscienceResearch #MedicalScience

I love “psilocybin-maxxed” it’s so ‘26 Jump Street. Trying to buy weed by telling a high school dealer you’re “finna get phytocannabinoid-pilled”

The Pathological Rejection of Data: A Clinical Analysis The debate surrounding the lethality of THC versus alcohol is no longer a matter of policy preference; it is a litmus test for basic cognitive function. To maintain a belief system that equates the two—or favors the latter—requires a total severance from empirical reality. The Lethality Gap: Biological Fact vs. Social Fiction The biological "bottom line" is established by the Median Lethal Dose (LD50). • Alcohol (Ethanol): A known systemic neurotoxin and carcinogen. It accounts for approximately 3 million deaths annually via acute toxicity, organ failure, and withdrawal-induced seizures. • THC: A phytocannabinoid with no known LD50 in humans. There is zero documented evidence of fatal overdose via organ failure or respiratory depression in clinical history. The Diagnosis: Systematic Delusion In psychiatric practice, a Delusion is defined as a "fixed belief that is not amenable to change in light of conflicting evidence." When an individual is presented with the stark mortality gap between these two substances and yet continues to categorize THC as "dangerous" while accepting alcohol as "socially manageable," they are exhibiting a systematized delusional disorder. By the medical community’s own diagnostic criteria, this rejection of evidence is not a "difference of opinion"—it is a pathological break from reality.

Dr. Ethan Russo, a neurologist and leading cannabis researcher, has emphasized that cannabis stands out among medicinal plants due to its exceptional chemical diversity. His research highlights that cannabis contains a wide range of biologically active compounds, including cannabinoids, terpenes, and flavonoids, which interact with the body’s endocannabinoid system. Rather than acting through a single pathway, these compounds work together to influence pain regulation, inflammation, neurological balance, and immune response. Russo’s work helped shape the concept of the “entourage effect,” suggesting that whole-plant cannabis may offer broader therapeutic potential than isolated compounds alone. He consistently stressed that cannabis should be approached as a scientifically grounded medical tool, requiring careful study, appropriate dosing, and clinical oversight rather than hype or stigma. #CannabisScience #EthanRusso #EndocannabinoidSystem #MedicalCannabis #EvidenceBasedMedicine #PlantMedicine #OnlyFacts Russo, E. B. (2004). Clinical endocannabinoid deficiency (CECD): Can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions? Neuro Endocrinology Letters, 25(1–2), 31–39. Russo, E. B. (2011). Taming THC: Potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. British Journal of Pharmacology, 163(7), 1344–1364.

Is Cannabidiol (CBD) a Non-Psychoactive Phytocannabinoid? mdpi.com/2813-1851/5/1/4

CBC or Cannabichromene is an important non-psychoactive cannabinoids that may be involved in neurogenesis. Cannabichromene (CBC) is a non-intoxicating phytocannabinoid with several interesting mechanisms of action: Receptor Interactions: CBC has relatively weak affinity for CB1 and CB2 cannabinoid receptors compared to THC It acts as an agonist at TRPA1 (transient receptor potential ankyrin 1) channels It activates TRPV1 (vanilloid receptor 1) channels, though less potently than CBD These TRP channel interactions likely contribute to its analgesic and anti-inflammatory effects Endocannabinoid Modulation: CBC appears to enhance endocannabinoid tone by inhibiting anandamide uptake and degradation It may inhibit endocannabinoid membrane transporter (EMT) activity This leads to increased levels of endogenous anandamide, producing an "entourage effect" Anti-inflammatory Activity: CBC reduces inflammation through pathways independent of cannabinoid receptors It inhibits lipooxygenase and cyclooxygenase enzymes involved in prostaglandin synthesis The TRP channel activation contributes to anti-inflammatory signaling Neural Effects: CBC shows positive effects on neural stem progenitor cells (NSPCs), potentially enhancing neurogenesis It may have antidepressant properties through these neurogenic mechanisms Some evidence suggests neuroprotective effects Other Mechanisms: Antimicrobial activity against certain bacteria and fungi Potential anti-tumor effects through various pathways The combination of TRP channel activation and endocannabinoid enhancement makes CBC particularly interesting for pain and inflammation research, though clinical studies remain limited.

Ironically, this can be caused by consuming too much cannabis! It can clog the receptors, requiring a tolerance break. This applies to all cannabinoids, so keep that in mind when upping your dosages. The other mechanism is a lack of phytocannabinoid production by our own bodies

Cannabitriol (CBT), a phytocannabinoid from oxidation of THC shows promise. CBT is also a non-psychoactive compound. 👇👇👇👇👇

FIRST OF ALL, cannabis is stripped of most cannabinoids except CBG/THC.. CBG being the better of the two. WHAT THEY WONT TELL YOU, is that youre taking a PhytoCannabinoid (PHYTO-From Plant) And that with excercise, good water, air, your body makes them on there own. Cannabis=NO

Copaiba is a much more cost effective option. Copaiba’s main chemical constituent is beta-caryophyllene, a phytocannabinoid. A cannabinoid is the name used for anything that interacts with the endocannabinoid system. This system in your body is responsible for helping to regulate the inflammatory system, immune function, sleep, pain receptors, hormones, and more. Yesterday, President Trump posted a promo video for The Commonwealth Project, founded by Howard Kessler. This project is working to “prioritize the 65 population by integrating medical cannabis into mainstream healthcare for seniors” CBD / cannabis has become a major money maker for very few. It’s funny we see support for it now.

Our Philotimo brand salves are made with a balanced combination of CBG and CBD in a phytocannabinoid-rich h*mp oil, certified Minnesota Grown beeswax by Gardner Bees in Sleepy Eye, MN, and aromatic essential oils that helps soothe discomfort and support skin health.

Brazil | Lab to Classroom: Medical Cannabis Academic Training Prepares future health professionals with practice, science & responsibility UniRios developed practical activity for Pharmacy students on handling & extraction of phytocannabinoid-based oils. sechat.com.br/es/noticia/del…

Cannabidiol in Skin Health: A Comprehensive Review of Topical Applications in Dermatology and Cosmetic Science (CBD), phytocannabinoid derived from Cannabis sativa L., has emerged as a promising multifunctional agent in dermatology and cosmetic science. mdpi.com/2218-273X/15/9/1219