Cell and gene therapies have the potential to offer a much higher quality of life to patients. Getting transcriptional control right is going to unlock a whole new class of them. Happy to share a small preview into Axis’ ability to design novel regulatory DNA sequences. It’s so obvious that evolution has only explored a drop in the whole ocean. Now finally with AI can we start to take a deep dive.

AI x Bio teams like Origin have coding agents, scaling laws, and a wave of big biotech deals all at their backs. This is barely touched territory. Crazy what this small team can do now.

Today, we're excited to release 10,000 fully AI-designed enhancer sequences for the research community. Axis was prompted to design sequences with targeted activity in one of three widely used cell-lines. AI allows us to explore a vast design space, going beyond the natural genome.

Burt (@trainburt) is building AI teammates for logistics. Teammates that can handle the manual, repetitive work that freight brokers and forwarders deal with every day. Congrats on the launch, @bobbyzhong333 & @zerodaykurt! ycombinator.com/launches/Pc6…

Muon can accelerate LLM training, but does that benefit transfer to regulatory DNA sequence modeling with its different data distribution? 🧬 Our results show that Muon with independent weight decay (MuonW) hits our validation perplexity target in ~37% fewer FLOPs than the best Adam configuration.

It was an honor to meet PM @narendramodi and discuss the potential impact of the work we are doing at @origin_bio

.@PirisLabs delivers low-latency, low-cost AI inference by eliminating the memory wall using full-stack optical interconnects and a purpose-built software stack. Congrats on the launch Ali & Keyvan! ycombinator.com/launches/PQd…

Check out the second episode of The Token Economy podcast with @malhar317 from @origin_bio

.@dittobio discovers drugs for autoimmune diseases by harnessing parasite biology. Viruses, ticks, and worms have experimented over millions of years to create proteins that control the human immune system. Ditto Bio is using AI to identify these natural, drug-like proteins and engineer them into next-generation autoimmune therapies. Congrats on the launch @AdairLBorges, @Mezarque, and @emilycpierce! ycombinator.com/launches/PNb…

.@autumn_ai_inc is building the first real-time signal intelligence platform for GTM teams. Define your ICP and the signals that matter, and Autumn delivers a condensed, real-time feed filtered by intents. Congrats on the launch @VishnuSampathk1 and @shiv_kampani! ycombinator.com/launches/PNL…

This is a very special team. True pair of polymaths at the intersection of computer science and biology. Their first model beat Deepmind's AlphaGenome on benchmarks and they're now using that to design cell and gene therapies. Congrats on the launch!

Transformers extending to bio is one of those things that just feels obvious - what is the molecular machinery of life, if not a language? Yash & Malhar are the real deal. Wicked sharp. Excited to support them as they shred legacy approaches.

We're still in the early days of durable and long lasting drugs based on transcriptional control - similar to where mRNA medicines were many years ago! With AI designed regulatory DNA and millions of sequences we're lab testing, we aim to precisely program gene expression @origin_bio

Origin (@origin_bio) is using AI to make safer cell & gene therapies for diseases like cancer. Their model designs DNA switches & dials to program precise gene expression patterns in disease cells. Congrats on the launch @YashRathod_75 and @malhar317! ycombinator.com/launches/PMG…

Keytruda is one of the most important cancer drugs in history, saving countless lives and generating $30B per year in sales. But how does it work? I break down the molecular mechanisms in this blog post, with interactive visualizations 👇

Interested in knowing more about how we beat Google DeepMind? We shared some insights on @tbpn

On TBPN live, our co-founder and CEO shares more on how we plan to use Axis to develop new age gene therapies👇

That is literally alien tech in its infancy. In 20 years when most diseases have cures and humans live to 200 years, it will be because of start-ups like Origin. So lucky to be able to call @malhar317 and @YashRathod_75 my friends - the future is bright.

Axis is promptable. Provide a regulatory element type (promoter or enhancer) with transcription factor (TF) proteins and it generates candidate sequences that enable the binding of those proteins.

Going on TBPN at 1:45 pm PT to launch @origin_bio and our model, Axis. Axis is the first model that generates regulatory DNA sequences and predicts its function. Axis already outperforms DeepMind's AlphaGenome on various benchmarks!