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Code script @nonstandardcode

Code script

Joined June 2020
  • Tweets 683
  • Following 5,431
  • Followers 801
10 Photos and videos
Code script retweeted
Jennbrophy.bsky.social@jennbrophy7
Jun 4
Excited to share our new preprint "Genetic code expansion enables plant-directed control of bacterial activity", a fantastic collaboration with @kunjapur lab! biorxiv.org/content/10.64898…

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Filippo Caschera
@Stjle
May 26
PURE makes PURE: reconstitution of the PURE cell-free system from self-synthesized proteins nature.com/articles/s41467-0…

PURE makes PURE: reconstitution of the PURE cell-free system from self-synthesized proteins

Nature Communications - Building a self-replicating biochemical system remains a challenge in synthetic biology. Here the authors demonstrate that the cell-free protein synthesis PURE system can be...

nature.com
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BioFaction@BioFaction
May 13
Apply to the Microbial Fuel Cells MudTronics competition: mi-hy.eu/mudtronics/ MudTronics is a collaborative competition that brings together bio, tech, and art/design to explore what we can do with microbial fuel cells. Deadline June 6th, 2026
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Harris Wang@harriswangnyc
Apr 30
1/ Excited to share our new paper in Science: “Toward life with a 19-amino acid alphabet through generative artificial intelligence design.” @ColumbiaSysBio @ColumbiaBME @Columbia science.org/doi/10.1126/scie… 🦠🧬🛠️🖥️💥

Toward life with a 19–amino acid alphabet through generative artificial intelligence design

Because all known living organisms are made from at least 20 canonical amino acids, the feasibility of life using a more simplified alphabet remains unclear. In this work, we leveraged computational...

science.org
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Hideaki E. Kato@emeKato
Apr 17
science.org/doi/10.1126/scie… これはreverse translationの入口と言っても良いのでは・・・？こんな驚きのタンパク質が自然界から見つかってくるからこそ、遺伝子マイニングはやめられませんね。。

Protein-templated synthesis of dinucleotide repeat DNA by an antiphage reverse transcriptase

Defense-associated reverse transcriptases (DRTs) are widespread bacterial anti-phage systems that use unconventional mechanisms of polynucleotide synthesis. We show that DRT3, which comprises two...

science.org
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Code script retweeted
Shixian Lin
@Linlab_ZJU
Mar 19
Excited to share our new paper in @NatureChemistry! Building on our Rare Codon Recoding (RCR) work @ScienceMagazine, we developed a multi-rare-codon strategy enabling the simultaneous incorporation of up to 5 distinct ncAAs in mammalian cells! nature.com/articles/s41557-0…
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Devon Stork@StorkDevon
17 Oct 2025
What's great about this is that we can finally start putting numbers on the big questions in terraforming research. arxiv.org/abs/2510.07344

An Introduction to Mars Terraforming, 2025 Workshop Summary

Terraforming Mars is an age old science fiction concept now worth revisiting through the lens of modern science and technology. This document serves as a summary of contemporary ideas about Mars...

arxiv.org
PioneerLabs
@Pioneer__Labs
17 Oct 2025
Mars could be green in our lifetime, but you’d still need an oxygen mask. With new capabilities in spaceflight & synthetic biology, current plans for Mars terraforming look very different from past visions. A thin, life-supporting atmosphere might be doable with modern tech.
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Matthaeus Schwarz-Schilling@matthschwa
27 Aug 2025
Simultaneous in vitro expression of minimal 21 transfer RNAs by tRNA array method by Miyachi, R., Masuda, K., Shimizu, Y., Ichihashi, N. nature.com/articles/s41467-0…

Simultaneous in vitro expression of minimal 21 transfer RNAs by tRNA array method

Nature Communications - tRNAs are essential for translating genetic information into proteins. Here, the authors develop a method to synthesize all 21 essential tRNAs from a single DNA in vitro,...

nature.com
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Thioester-mediated RNA aminoacylation and peptidyl-RNA synthesis in water nature.com/articles/s41586-0…

Thioester-mediated RNA aminoacylation and peptidyl-RNA synthesis in water

Nature - Aminoacyl-thiols reacting selectively with RNA diols over amine nucleophiles and demonstration of chemically controlled formation of peptidyl-RNA in water at neutral pH suggest an...

nature.com
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Sebastian S. Cocioba🪄🌷@ATinyGreenCell
31 Jul 2025
If you are an highschool student and you are conducting research in a lab, you are a scientist. If you are an undergraduate student and you are conducting research in a lab, you are a scientist.
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Machine learning-guided evolution of pyrrolysyl-tRNA synthetase for improved incorporation efficiency of diverse noncanonical amino acids rdcu.be/ew4uf
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Princeton Chemistry@PrincetonChem
2 Jul 2025
Michelle Chang of @PrincetonChem and colleagues publish in @NChemBio: “Terminal alkyne formation by a pyridoxal phosphate-dependent enzyme.” Great work! nature.com/articles/s41589-0…
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From the chin lab Genetic Code-Locking Confers Stable Virus Resistance to a Recoded Organism | Biochemistry pubs.acs.org/doi/10.1021/acs…

Genetic Code-Locking Confers Stable Virus Resistance to a Recoded Organism

The genetic code defines the correspondence between codons in genes and amino acids in proteins. Reassignment of sense codons to different amino acids can create cells with refactored genetic codes...

pubs.acs.org
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Matthieu Gagnon@gagnon_lab
19 Jun 2025
2 of 2: Instead of activating a water molecule for hydrolysis, as previously thought, release factors induce a structural change in the transfer RNA, enabling its own 2’OH group to attack and break the bond, a universal process in all organisms. science.org/doi/10.1126/scie…

Mechanism of release factor–mediated peptidyl-tRNA hydrolysis on the ribosome

Translation termination is essential in all living organisms because it ensures that proteins have lengths strictly defined by their genes. This universal process is mediated by peptide release...

science.org
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Structure@Structure_CP
16 Jun 2025
Online now! The continuous evolution of biomolecular force fields dlvr.it/TLNb6S

The continuous evolution of biomolecular force fields

In this review, Lu et al. discuss the evolution of biomolecular force fields, highlighting recent advances in classical additive models, polarizable models, coarse-grained approaches, and machine...

cell.com
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Stephen Tang@stephentang23
28 May 2025
Excited to share our newest paper, online today @Nature! We report the discovery of a highly unusual mechanism of antiviral immunity through the synthesis of long, homopolymeric DNA. nature.com/articles/s41586-0…
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Patrick Bryant@Patrick18287926
27 May 2025
There is also a Colab notebook for EvoBindRare now! Try it and let us know what you think: colab.research.google.com/gi…

rarefold.ipynb

Run, share, and edit Python notebooks

colab.research.google.com
Patrick Bryant@Patrick18287926
24 May 2025
RareFold predicts and designs proteins with noncanonical AAs. With EvoBindRare, we designed linear & cyclic peptide binders with high affinity & novel binding modes, validated in wet lab. A step toward next-gen therapeutics. 📄 biorxiv.org/content/10.1101/… 💻 github.com/patrickbryant1/Ra…
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Chang Liu
@chang_c_liu
24 May 2025
Happy to share the peer-reviewed and updated version of our work on OrthoRep-driven evolution of aaRSs for genetic code expansion with unnatural amino acids. Congrats to @yuichi_furuhata, a true master bioengineer, on leading this excellent work! nature.com/articles/s41467-0…

Directed evolution of aminoacyl-tRNA synthetases through in vivo hypermutation

Nature Communications - Genetic code expansion (GCE) enables the incorporation of new amino acids into proteins. Here, authors demonstrate the rapid OrthoRep-driven evolution of aminoacyl-tRNA...

nature.com
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Tess van Stekelenburg
@velvetatom
9 May 2025
Pushing the bounds of human capability across frontiers of intelligence, space & biotech is a mission I care deeply about. As federal science budgets enter a period of uncertainty - we're excited to step up with $100M for engineers & inventors affected by funding cuts.
Lux Capital
@Lux_Capital
9 May 2025
1/ We're dedicating $100M to support American scientists facing funding cuts through the Lux Science Helpline, an expansion of our Lux Labs program. To compete in the future, innovation must be funded 🧪💡
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bioRxiv Synthetic Biology@bioRxiv_synbio
2 May 2025
Escherichia coli with a 57-codon genetic code biorxiv.org/content/10.1101/… #biorxiv_synbio

Escherichia coli with a 57-codon genetic code

The near-universal genetic code of living organisms uses 64 codons to encode the 20 canonical amino acids in protein synthesis. Here we design and generate a variant of Escherichia coli with a 4 Mb...

biorxiv.org
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