Over and over again, modern behavioral genetics studies have revealed how flawed the assumption of "equal parts nature and nurture" has been. But the myth remains embedded in the conventional wisdom because numbers in the middle feel intuitively "correct".
1/ We are excited to share our report in @JExpMed showing that about 40% of cases of #WestNilevirus (#WNV) encephalitis are due to pre-existing auto-Abs neutralizing type I IFNs, making WNV encephalitis the best understood human infectious disease (rupress.org/jem/article/220/…).
Pls RT! Great opportunity to attend a Summer School exclusively focused on AI & machine learning for healthcare! Offering talks, a mentorship program, student mini-projects, roundtables, networking & an online exhibition. 5-9 Sept. Learn more: tinyurl.com/2p8wue2z @minouye271
join me & @EricJCGalvez with the rest of the @Roche's pRED microbiome team in Basel to intertwine human genetics & microbiome! open postdoc position here tinyurl.com/56xmwc9z
Very pleased to share this exciting new work, a highly collaborative effort, on the development, validation and application of genetic scores for a wide range of multi-omic traits.
Preprint: biorxiv.org/content/10.1101/…
Online Portal: omicspred.org
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Pleased to announce our recent work is now live @CellGenomics, in which we show machine learning optimized polygenic scores for blood cell traits can stratify sex-specific trajectories and identify genetic correlations with disease.
cell.com/cell-genomics/fullt…
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Pleased to announce our latest work is now live at Nature Metabolism (@natmetabolism), in which we show polygenic risk scores (PRS) can be used to identify novel and causal proteins underlying disease risk.
nature.com/articles/s42255-0…
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We studied microbiome dynamics in 245 FMT cases across 13 studies where fecal transplants were used to treat patients who suffered from rCDI, IBD, Metabolic Syndrome, Drug-Resistant Pathogen colonization, or went through ICI anti-tumor therapy.
x.com/DanielPodlesny/status/…
Super excited to release genebass.org, a web application for browsing association results for 3,700 phenotypes across 281,850 individuals from the UK Biobank. The site features plots, tables, and controls for exploring billions of associations.
Happy to finally share this manuscript - large-scale Crohn's exomes from IIBDGC demonstrates complementarity of GWAS and exome findings and many new CD genes. Unlike neurodev - most signal from more common low-frequency variants medrxiv.org/content/10.1101/…
We're thrilled to release a manuscript on rare variant association testing on the exomes of 300k individuals in the UK Biobank medrxiv.org/content/10.1101/… and a browser of the results: genebass.org