Associate Professor @UofIllinois studying influenza, SARS-CoV-2, antibodies, evolution, and protein structures.
Joined December 2014
- Tweets 621
- Following 323
- Followers 883
- Likes 1,671
40 Photos and videos
Nicholas Wu retweeted
21 Nov 2025
This preprint just came out. @wchnicholas and team reconstructed and tested the NJ Spike and found that it has the tightest ACE2 binding of any SC2 Spike ever measured.
2/
medrxiv.org/content/10.1101/…
4
18
180
9,054
Nicholas Wu retweeted
21 Nov 2025
This is wild.
Remember the NJ crytic lineage?
I posted 18 months ago that the Spike was too divergent to predict ACE2 binding, and asked if someone else could figure it out.
Some colleagues took me up on it.
Guess what they found?
1/
x.com/SolidEvidence/status/1…
15 Feb 2024
New Jersey Cryptic lineage update.
Background: Cryptic lineages are evolutionarily advanced SARS-CoV-2 lineages detected in wastewater from an unknown source.
We are fairly certain that these are derived from patients with persistent SARS-CoV-2 infections.
1/
5
116
547
66,639
Nicholas Wu retweeted
21 Nov 2025
Excited to share our recent study (collaborated with @wchnicholas @SolidEvidence) of a wild cryptic lineage, NJ, detected in wastewater.
Notably, it carries 39 unique substitutions on the RBD, and exhibits the highest ACE2 binding affinity and extensive antibody evasion.
2
8
21
1,648
Nicholas Wu retweeted
19 Nov 2025
Evolution of Ab cross-reactivity to influenza H5N1 NA:
Isolation & characterization of protective antibody against influenza neuraminidase that acquires cross-reactivity to avian H5N1 as a byproduct of affinity maturation against human H3N2 @wchnicholas
cell.com/cell-host-microbe/a…
2
5
1,065
Nicholas Wu retweeted
22 Oct 2025
Evolution of Ab cross-reactivity to influenza H5N1 NA:
New work isolates & characterizes protective antibody against influenza neuraminidase that acquires cross-reactivity to avian H5N1 as a byproduct of affinity maturation against human H3N2 @wchnicholas
cell.com/cell-host-microbe/a…
2
9
1,159
Nicholas Wu retweeted
4 Sep 2025
Excited to share that the oPool⁺ display is on the cover of this week's @ScienceTM! We hope that the future use of this platform can accelerate antibody characterization, benefit therapeutic & vaccine development, and facilitate iterative refinements of antibody AI models.
3 Sep 2025
Don't miss the new issue of #ScienceTranslationalMedicine!
A clinical study in Nepal shows that waning immunity to Japanese encephalitis virus can worse the severity of dengue, a new platform leapfrogs laborious obstacles in antibody discovery, and more. scim.ag/3JBJc1Y
1
2
5
525
Nicholas Wu retweeted
14 Jul 2025
Reaching out to senior scientists can feel daunting, but it’s often less intimidating—and more rewarding—than you’d expect.
In this @ecrLife article, I share my experience as an early-career researcher and encourage others to take that step too.
ecrlife.org/reaching-out-to-…
2
1
222
Nicholas Wu retweeted
4 Apr 2025
New in @JExpMed! 🆕
Researchers alongside Drs. Ali Ellebedy, Nicholas Wu, and @florian_krammer investigated the breadth of anti-NA B cell responses to seasonal #influenza vaccination in humans.
📖 Learn more: bit.ly/3XJ0L4g
7
23
5,026
Nicholas Wu retweeted
3 Apr 2025
We are hiring a highly motivated postdoctoral fellow to study the molecular biology and pathogenesis of enteric viruses that cause diarrhea in human infants. More details on the Ding Lab website - sdinglab.wustl.edu. DM or email me!
1
16
28
2,896
Nicholas Wu retweeted
4 Mar 2025
In this latest version of the preprint, we are excited to (re)introduce oPool display, a high-throughput cell-free platform that enables rapid synthesis and specificity characterization of natively paired antibodies at an unprecedented scale (1/): biorxiv.org/content/10.1101/…
1
3
18
2,352
Nicholas Wu retweeted
1 Sep 2024
I am excited to share our latest work, where we developed oPool display, a rapid and cost-approach to synthesize and screen natively paired antibodies in a highly parallel fashion (1/14): biorxiv.org/content/10.1101/…
3
5
34
3,952
Nicholas Wu retweeted
29 Jun 2024
The Ding Lab at the Washington University in St. Louis (sdinglab.wustl.edu/) is hiring! We are looking for motivated postdocs and technicians to study rotavirus biology and vaccines using viral reverse genetics, mouse models, and human intestinal organoids. Spread the word!
6
105
175
30,970
Our paper on SARS-CoV-2 fusion peptide and coronavirus DMS is now available online @NatureComms
Great collaboration with @wchnicholas and @RuipengUIUC !
nature.com/articles/s41467-0…
2
4
25
1,937
Nicholas Wu retweeted
11 Feb 2024
I am so glad to receive travel award for #BPS2024. Come to the poster session on Feb 14th(B477 , 10:30 AM - 12:30 PM) to learn about antibody, deep learning and language model!
1
4
687
Nicholas Wu retweeted
1 Feb 2024
excited to share that our paper on equivariant model for protein structure to function map, led by Mike Pun, is now published in @PNASNews
pnas.org/doi/10.1073/pnas.23…
2 Nov 2022
Check out our new preprint (led by Mike Pun @UW) on 3D rotationally equivariant model of protein structure micro-environments, with a holographic CNN (H-CNN): doi.org/10.1101/2022.10.31.5…
6
25
3,082
Nicholas Wu retweeted
2 Jan 2024
I love running, and I love helping people more. In 2024, I want to combine two of my favorite things by running the @ChiMarathon as a @MercyHome hero! Please join me in helping children in need, one step at a time:) #Resolutions2024
marathon.mercyhome.org/chica…
1
1
7
652
Nicholas Wu retweeted
20 Nov 2023
Stringent and complex sequence constraints of an IGHV1-69 broadly neutralizing antibody to influenza HA stem dlvr.it/Sz4Cs3
1
8
32
9,643
Nicholas Wu retweeted
18 Nov 2023
Very nice new paper characterizing anti-N2 mAbs by @wchnicholas and the now twitter-less Ali Ellebedy. Thanks for including my team.
cell.com/immunity/pdfExtende…
1
30
42
18,782
Nicholas Wu retweeted
14 Nov 2023
Three protective Abs that cross-react with neuraminidases from seasonal H3N2 strains spanning multiple decades with implications for developing broadly protective influenza vaccines @wchnicholas @ImmunityCP
cell.com/immunity/fulltext/S…
1
26
52
14,477
Nicholas Wu retweeted
3 Nov 2023
Phenotypic homogeneity of cells with genomic “landing pad” transgene integration can simplify assays for protein function. We made double landing pad HEK cells that reproducibly allow two independent single-copy integrations, with some new possibilities. pubs.acs.org/doi/10.1021/acs…
3
12
53
5,759