computational biologist. DNA damage and repair.
Joined April 2017
- Tweets 261
- Following 232
- Followers 147
- Likes 530
Photos and videos
Pinned Tweet
Mar 7
Excited to share our new collaborative work with Lu Wang’s lab @LuWang_TE ! We uncover a de novo H3.2K9me2 deposition pathway that establishes heterochromatin to suppress transposon mobilization during fly somatic development.
doi.org/10.1093/nar/gkag146
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Wei Wu retweeted
Jan 28
Excellent opportunity in excellent lab.
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I am looking for a postdoc to develop high-performance algorithms in computational genomics. Email or DM me if interested. For more information, see hlilab.github.io/vacancies. RTs appreciated!
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Wei Wu retweeted
25 Nov 2025
🚨New pre-print out!🚨
Exciting collaboration with the Meek and Schmidt labs at Michigan State University. We discovered that Ku inhibits aberrant splicing caused by intronic Alu repeats.
biorxiv.org/content/10.1101/…
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31 Oct 2025
Two fresh papers from WuLab!
📊 A benchmark of ploidy estimation tools for bulk & single-cell WGS.
🧬 With Dr. Haiqiang Dai’s team, we built a complementary and affordable TCR profiling assay.
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31 Oct 2025
links to these papers:1 advanced.onlinelibrary.wiley…
2: advanced.onlinelibrary.wiley…
Congrats to my students Yawei and Zilv, and to my wonderful collaborators Haiqiang and Rui from his lab!
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Wei Wu retweeted
24 Oct 2025
Ever noticed that #CRISPR editing results differ between cells? Awesome PhD student @MSchlapansky developed "scOUT-seq" to measure single cell transcriptomes editing. 1.2 million cells, 74 cell types, living 🐭. Cell subtypes differ wildly from bulk! biorxiv.org/content/10.1101/…
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Wei Wu retweeted
10 Sep 2025
New work from the lab! 🔬 We report that DDIAS is a new component of the mitotic CIP2A-TOPBP1 pathway of genome maintenance.
biorxiv.org/content/10.1101/…
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11 Sep 2025
Huge congrats Shuo!
10 Sep 2025
Excited to share the first paper from my lab in @Nature ! We repurposed the widely used research tool, proximity labeling, to demonstrate its therapeutic potential in antigen amplification for immunotherapy using mouse tumor models and patient samples.
nature.com/articles/s41586-0…
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Wei Wu retweeted
28 Aug 2025
JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada. We provide a generous startup, fully funded salary and academic appointment at U of Toronto.
nature.com/naturecareers/job…
Please repost!
ALT Image of Toronto
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Wei Wu retweeted
25 Jun 2025
Cytarabine has been the mainstay for AML treatment. This chemotherapy can lead to problems with movement and balance. Here we explain this neurotoxic side effect: nature.com/articles/s41586-0…. Work led by Jia-Cheng Liu, Donpgeng Wang, Elsa Callen and many terrific collaborators!
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Wei Wu retweeted
5 Jun 2025
Happy to share our updated opinion on the physiological roles of BRCA1 in this new review: authors.elsevier.com/a/1lDKu…
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Excited to share our new paper on Nature - how Ku accommodates Alu expansion in primates by binding to dsRNA, providing a clue for both the high levels of Ku and its essentiality in human cells. Thank @chaolinzhang @hchung03 @LenaSteckelberg More to come
nature.com/articles/s41586-0…
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Wei Wu retweeted
13 May 2025
Our amazing group for #Recombination25!
It’s been an fantastic few days of science, networking, and collaborations🥳
Lets celebrate in style at tonight’s gala dinner! 🎉💃
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Happening Now in the Skyline Ballroom: Andre Nussenzweig is presenting his lecture, "Maintaining genome stability."
asbmb.org/asbmb-today/people… #ASBMB25
ALT Andre Nussenzweig delivers his award lecture on genome stability at the 2025 ASBMB Annual Meeting.
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Wei Wu retweeted
24 Mar 2025
We're incredibly excited to share our new method, Paired-Damage-seq, out @naturemethods today! This technique allows us to jointly analyze oxidative DNA damage and SSBs with RNA, all at the single-cell level (1/5). nature.com/articles/s41592-0…
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Wei Wu retweeted
12 Feb 2025
Learn how homology search might work in 3D genome! We combine very fast CRISPR and Hi C to look at 3D genome changes during DNA repair and found that break anchored DNA extrusion by cohesin can help search for homologous sequences.
12 Feb 2025
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Really excited to share our latest pre-print on the role of cohesin in homology search, now available on bioRxiv!
biorxiv.org/content/10.1101/…
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8 Feb 2025
Delighted to share this beautiful story of collaboration with Lu's and ZZ's groups! Thank you for introducing me to the fascinating world of transposon elements.
8 Feb 2025
Thrilled to share the first preprint from our labs @weiwsmiling and @zz_zhaozhang! biorxiv.org/content/10.1101/…
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Wei Wu retweeted
19 Dec 2024
Check out our latest pre-print: we show that the LINE-1 retrotransposon is a potent source of chromosomal rearrangements and instability in addition to insertional mutagenesis using shotgun and long-read WGS.
@KathleenHBurns @JenniferAKarlow
biorxiv.org/content/10.1101/…
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Wei Wu retweeted
3 Dec 2024
Online Now: Repair of replication-dependent double-strand breaks differs between the leading and lagging strands dlvr.it/TGYr69
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