We're learning a lot about cellular senescence, how to track it, and its role in aging and disease. Cover and commentary @CellCellPress cell.com/cell/fulltext/S0092…

Bioelectric signaling as an emerging layer of macrophage communication dlvr.it/TSywZ6 #immunology

Very pretty: Researchers introduce a streamline-wise framework to map axonal degeneration & derive disease-specific fiber “degeneromes” across #Alzheimers, #Parkinsons, multiple system atrophy (MSA), & progressive supranuclear palsy (PSP) nature.com/articles/s41531-0…

Activity-dependent protein synthesis in neurons requires microglial-metabolic coupling: Cell Metabolism cell.com/cell-metabolism/ful…

Mitochondria directly interact with the nuclear pore complex | Nature nature.com/articles/s41586-0…

The endolysosomal system in conventional and unconventional protein #secretion. A Perspective by Eloïse Néel, Marioara Chiritoiu-Butnaru, Julien Villeneuve and colleagues: hubs.la/Q04ghNw60 📕 In #Lysosomes 2026: hubs.la/Q04ghLxS0

Microglia feet are highly dynamic and can be in contact with dense networks of axons. In this video by our #ElectronMicroscopy team using MICrONS data, a microglia (purple) contacts with an excitatory pyramidal neuron (gold). Slowly the axons under the feet are revealed.

Universal transcriptomic hallmarks of mammalian ageing and mortality | Nature nature.com/articles/s41586-0…

Microglial mitochondria transfer to astrocytes via GPNMB-enriched extracellular vesicles alleviates cognitive deficits in tauopathy mice @NatureNeuro

It feels very futuristic to imagine a world with one-and-done therapies that lower LDL cholesterol for life, but... it might not be far off! These are new phase 1 data for Verve/Lilly's PCSK9 base editor: one single intravenous infusion reduces LDL cholesterol by as much as 60%

Today in @Nature, we report MouseMapper: foundation-model AI to map disease perturbations across the entire mouse body cell-by-cell. In obesity, it revealed body-wide inflammation & unexpected facial nerve damage. 🧵👇🔉 nature.com/articles/s41586-0… led by @Dorie00 & @yingchen733

Try this new online training game from Leandro F. Estrozi designed for newcomers in structural biology, with a focus on cryo-EM and cryo-ET map interpretation: rico.ibs.fr/helixplorer/reso…

Las figuras deben ser lo más simples posibles. Figura 1: a) Un diagrama demasiado complicado de una inversión en dos genes. b) Una versión simplificada, combinando los dos primeros pasos y usando menos flechas.

The brain is becoming testable. In 2025, Nature showed brain organoids can now be imaged live for weeks, tracking human-like tissue self-organization in real time [1]. A 2024 Nature Reviews roadmap says these 3D models are moving beyond “mini-brains” toward disease modeling, drug screening, and development biology at scale [2] 🧠 Why it matters: animal models keep failing in neurology. Organoids give researchers a more human platform for Alzheimer’s, epilepsy, autism, ALS, and rare disorders but the talent, compute, biomanufacturing, and ethics gaps are widening fast ⚖️ The next edge will not be who grows the prettiest organoid. It will be who can standardize, validate, and regulate them well enough for real decisions. 🤔 What would change your mind: are brain organoids overhyped tools, or the next serious platform for neurological R&D? [1] [nature.com/articles/s41586-0…](nature.com/articles/s41586-0…) [2] [nature.com/articles/s41580-0…](nature.com/articles/s41580-0…) [3] [cell.com/cell-stem-cell/full…](cell.com/cell-stem-cell/full…) #BrainOrganoids #Neuroscience #DrugDiscovery #Biotech

In @natrevbioeng, Core Investigator @FelixHorns and colleagues outline how engineered living cells could deliver mRNA to places lipid nanoparticles and viral vectors can't reach, homing to disease sites and activating only when they detect the right signals.

Generating exosome subtypes: diverse membrane origins and mergers dlvr.it/TS1HNG

Enjoy!! researchgate.net/profile/Aru…

Graduate students increasingly use artificial-intelligence tools to draft, code and search — but many fear it could erode the very skills a doctorate is meant to build go.nature.com/4bmCOaa

Potential of mitochondrial transfer to prevent or treat Parkinson' s disease, in mouse and monkey models @CellCellPress cell.com/cell/fulltext/S0092…

Mitochondria acidify lysosomes through membrane contacts @uofcincy @SunLabUCin sciencedirect.com/science/ar…