Assistant Prof @nyugrossman @Perlmutter_CC | Somatic mosaicism in cancer & aging 💻🔬 Opinions my own. Also at: bsky.app/profile/miapetljak.…
Joined July 2018
- Tweets 425
- Following 470
- Followers 1,322
- Likes 1,190
28 Photos and videos
DRMP retweeted
Jun 4
Exciting breakthrough technology from the lab, now live in @CellCellPress ! Instead of cutting the genome where proteins bind (e.g., Cut&Tag), D&D-seq scars the DNA with a deaminase, allowing single cell genome mapping of TFs and chromatin remodellers!
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DRMP retweeted
Apr 30
Excited to share our paper out today in @ScienceMagazine! We directed high-content, single-cell genetic screens to ask how a disordered adapter protein orchestrates the complex process of T cell activation. (1/4)
science.org/doi/10.1126/scie…
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DRMP retweeted
Apr 15
We're in this week's Nature! We propose a model of how a cell learns by running an evolutionary algorithm: exploring different gene-regulatory combinations and using feedback responses to stabilize those combinations that reduce stress levels.
Full text: nature.com/articles/s41586-0…
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DRMP retweeted
Apr 16
Only half of esophageal adenocarcinomas (EACs) are associated with background Barrett esophagus (BE). New integrated epidemiological & molecular data from @RFitzgerald_lab reinforces commonalities between the two reiterating that BE is universal precancer.
nature.com/articles/s41591-0…
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DRMP retweeted
Excited to share our latest work. Applying advanced single-molecule and single-cell DNA sequencing methods, we uncover an extraordinary landscape of somatic mutations in immune checkpoint genes in autoimmune lymphocytes. [1/n] rdcu.be/fdqbr
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DRMP retweeted
1 Dec 2025
latest from the lab --> how we used whole genome passenger somatic mutation patterns 🧬 to trace the origins of never-smoker lung adenocarcinoma (LUAD) to cells of the proximal lung 🫁 @NatureGenet nature.com/articles/s41588-0… 1/🧵
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Honored to be part of the 2025 class of #PackardFellows ✨ and deeply grateful to the Packard Foundation for supporting bold science that advances knowledge and real-world impact 🌎🧬🙏 packard.org/2025fellows
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DRMP retweeted
24 Apr 2025
Some trully trainee led science! @Elsa2Bernard @oriol_pich Maria Zagorulya - our work is done here!
Read how CH can influence solid tumor progression & treatment response ⬇️
@NEJM with the one & only @CharlesSwanton
@MSKCancerCenter @TheCrick
24 Apr 2025
🚨Thrilled to share our latest work: “Tumor-Infiltrating Clonal Hematopoiesis” @NEJM - we investigated how age-related blood mutations impact cancer when they infiltrate tumors, with @Elsa2Bernard Maria Zagorulya, @PapaemmanuilLab @CharlesSwanton more
nejm.org/doi/full/10.1056/NE…
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DRMP retweeted
11 Apr 2025
Excited to share our exploration @naturemethods into new horizons opening up in the era of low cost sequencing!
🔥 Deeper sequencing at WGS scale for PPM sensitivity of tumor informed MRD
🔥Duplex sequencing at WGS scale for plasma only exploration of ctDNA
Check out thread 👇
11 Apr 2025
What happens when sequencing costs go ⏬ ?
Imagination and new opportunities go ⏫ @landau_lab
Let's look at what you can do when you perform deep WGS on cfDNA for cancer detection. Our recent work with the @UltimaGenomics platform 🧵👇
Lets goooo!!
rdcu.be/ehkUb
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🚨OPEN POSTDOC
POSITION in our brand new lab space by Madison Sq NYC ! 🌆🧬🔬
Do experiments, learn computation, and uncover drivers of a major mutational process affecting >50% of cancers, driving therapy resistance & impacting immunotherapy responses👇
med.nyu.edu/research/postdoc…
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DRMP retweeted
19 Feb 2025
#mRNAvaccines for #PancreaticCancer (PDAC) PART4
1. Out today in @Nature nature.com/articles/s41586-0…
🧵👇🏽
[1/23]
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DRMP retweeted
25 Feb 2025
Our paper on Ultra-Rapid ddPCR (15 min tissue to result somatic mutation quantification) is now in @MedCellPress. A wonderful collaboration with @DanOrringerMD that succeeded because of the intrepid work of @ZacharyR_Murphy, Emilia Bianchini, and the team. cell.com/med/abstract/S2666-…
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👇breakthrough - non-opioid pain signaling inhibitor & first approved new class of pain medicine in >20 yrs 😮👏
30 Jan 2025
#Breaking: The U.S. FDA approves our treatment for moderate-to-severe acute pain in adults. This is the first new class of pain medicine to be approved in over 20 years. Learn more: news.vrtx.com/news-releases/…
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DRMP retweeted
22 Nov 2024
1/ Introducing SCimilarity, a new foundation model to explore scRNAseq data across tissues and diseases! It learns a common measure of cell similarity by training a deep metric learning model on millions of cells from various human tissues and conditions. nature.com/articles/s41586-0…
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DRMP retweeted
4 Nov 2024
Excited to share our latest work. We introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people. 1/n medrxiv.org/content/10.1101/…
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DRMP retweeted
21 Oct 2024
🌟 Congratulations to HHMI Investigators David Mangelsdorf and David Pellman who have been elected as members of the National Academy of Medicine (@theNAMedicine)! More: hhmi.news/3YywtBS
ALT David Mangelsdorf
ALT David Pellman
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