One thing I think people are massively missing in the GLP-1 / retatrutide debate: The populations in these studies are usually: -older -severely overweight or obese -metabolically unhealthy -often sedentary -low protein intake -not resistance training -on multiple cardiometabolic medications Then people in the biohacker / fitness space who are already 12–20% body fat, resistance training 4–6x/week, eating high protein, optimized hormones, good sleep, etc try to directly apply those outcomes to themselves. That’s where a lot of the confusion comes from. People keep making blanket statements like: “Look how much muscle loss happens on GLP-1s.” But in my clinical experience, younger healthier metabolically optimized patients often preserve muscle VERY well especially when: -protein is adequate -resistance training is present -weight loss is gradual -hormones are optimized -sleep/recovery are good Taking a 40-year-old lifter from 20% body fat → 15% body fat is NOT the same physiological situation as taking a 72-year-old sedentary diabetic from 38% body fat → 25%. Those are completely different humans with completely different metabolic environments. This is why individualized medicine matters. The real nuance isn’t: “Tirzepatide vs Retatrutide” or “GLP-1s are good/bad” The real nuance is: -Who is the patient? -What is their starting point? -What are their goals? -What are they doing with training, protein, hormones, sleep, and lifestyle while using these tools?

cRAZY hOW ExPensIVE cOMpOunDEd & bRAnD-NamE pEPtiDEs Are!!! tHEy OnLY cARe aBOuT mOney! -then shills affiliate link where they get 30-50% This is like saying: • "Why is electricity expensive when sunlight is free?" • "Why is bottled water more expensive than rainwater?" • "Why is peanut butter more expensive than peanuts?" • "Why is a meal at a restaurant more expensive than buying the same ingredients at the grocery store?" Because you're not paying for the molecule. You're paying for: -Professional time & overhead (rent, payroll, utilities) -Sterility / testing / quality control -Regulatory compliance / documentation -Liability / accountability So funny for me, as an ND, to have to defend Eli Lilly and other pharma companies. Are a lot of their prices criminally high? 100%. Are they the same product when you buy them from the gray market? Absolutely not. Of course raw peptide powder is cheaper. The real question is whether the savings are worth the increased risk of contamination, mislabeling, dosing errors, impurities, endotoxins, and having nobody accountable when something goes wrong.

Neighbors are trying to murder you... BUtT dA sToCK MArKEt iS At aN aLl TImE HiGh!!!!

Many things “Suppress Dopamine” -BPC-157 -Magnesium, taurine, theanine, glycine, and other GABAergic compounds dampen excitatory tone. -Meditation can reduce craving/reward-seeking circuitry. -Sleep suppresses wake-promoting dopamine/catecholamine activity. -Even caffeine, exercise, fasting, and stress all shift dopamine signaling depending on dose and context. The question isn’t “does NAC affect dopamine?” The question is: does NAC reliably suppress dopamine signaling enough to cause clinically meaningful anhedonia in humans?

BREAKING: Ozempic / Wegovy linked to ~30% lower breast cancer risk in 111,000 women (new Penn Medicine study at ASCO 2026). Even bigger: Women already diagnosed with breast cancer who took GLP-1s were 50% less likely to progress to Stage 4 (Cleveland Clinic data). Prevention slowed progression. Here's what the studies actually show — and the caveats. 🧵 #GLP1 #Ozempic #Wegovy #BreastCancer #ASCO2026

The Christian expression and heritage here is unmatched. Unsurprisingly, they are lying to us about Russia. ✝️

👀👀👀

Following a bit of the Protestant polemics against Orthodoxy recently, and I realize just how difficult it is to communicate the mind of the Church across these lines. A simple example is seeing people confused about whether someone who is not baptised and participating in Orthodox communion can be "saved". Protestant are noticing that there are different answers in their estimation, and so are confused about them. The confusion comes from the belief that being "saved" or not is about "where you go after you die", when for the Orthodox "saved" means being made whole, being healed, being restored to the original purpose God had for us. For this reason, when Protestants see declarations of how communion in the body of Christ is the only way to salvation, they immediately think this is a declaration that all the non-Orthodox are going to hell after they die. When Protestants then hear the very same person who just told them that salvation is in full participation to the body of Christ go on to intimate we have nothing to say about the eschatological finality of any specific soul, it is like a short circuit that many Protestants cannot compute. This is what I could see when @OrthodoxEthos and @Acts17David were discussing and it is what I have seen in @gavinortlund's videos. In a similar vein, when a Protestant says he has the "assurance of his own personal salvation", this is confusing to the Orthodox. Orthodox also obviously have assurance of salvation, that assurance is Christ. He shows us what it means to be made whole and makes us participate in that wholeness. But how can I say that I am "saved" if I see that I am still a wretch, still prideful and arrogant and sinful? So the Orthodox, knowing they are are still sinning, though also knowing Christ has made them grow in the virtues will say something like: "I know that I am being saved." That is I can see that I am being healed, being made whole, being reformed to the resemblence of God. But again, this completely confuses the Protestant who just wants to know what will happen when you die. What side of the fence will you end up on? I am not sure how to get accross these lines, and I feel that unless we can, we will perpetually be talking past each other.

WUT!? I've seen several doctors say this!?!? Lowering LDL does NOT mean you solved heart disease! Sure, one shot of "PCSK9 base editing" may reduce one major driver of atherosclerosis by lowering ApoB/LDL particle burden long term and that’s really cool and all, but heart disease isn’t just ‘LDL go up = heart attack.’ Existing plaque, calcification, Lp(a), endothelial dysfunction, hypertension, insulin resistance, inflammation, clotting risk, smoking history, metabolic disease, and lifestyle factors don’t magically disappear because you edited one gene. So Reducing LDL DOES NOT curing cardiovascular disease. Cool technology? Absolutely. Potentially game changing for certain high-risk patients? Maybe. Heck there maybe a chance it gives turbo cancer. We don't know yet. So this whole "One shot and you’re protected from heart disease’ is just click bait.

Why eat healthy? Why exercise? Why even inject Repatha? Just EDIT YOUR GENES bro 🥴😂😂🥴 Yeah I know, diet and exercise don’t always fix cholesterol because of genetics… Permanently rewriting your DNA is definitely the move. What could possibly go wrong?

I am this old

The health ignorance stuff has gone massively overboard. People walking around destroying their vital signs every second of the day like they're living in toxic soup straight out of a sci-fi movie. Eating ultra-processed food like it won't kill them if they look at it. Neglecting their sleep. Never counting their steps. It's possible to live a healthy life, but you have to be intentional and work hard at it the modern world is doing everything it can to make you sick. You're gonna die either way. In a few decades you can be strong, sharp, and showing up for the people you love, or you can be on four medications, metabolically wrecked, and wondering what happened. Take this seriously and live your healthiest life while you still can.

7 years ago, a good friend of mine, 32 years old, working full-time while raising 2 special needs children, came to me with every symptom of low testosterone. He told me: “Moe, I can either: 1) Work out in the morning 2) Show up great at work 3) Play with my special needs kids 4) Have energy for intimacy with my wife Most days I can do two. Some days three. But I can never do all four.” I told him to get tested. His testosterone came back at 232 ng/dL. Insurance required a second test. It came back at 254 ng/dL. He was told he was still in the “normal range” and denied treatment. So he went to a cash-pay clinic. They optimized his testosterone to ~800 ng/dL.7 years later: He’s in the best shape of his life Thriving at work Fully present for his children His marriage is stronger than ever He does all four now. Every day. A number on a lab sheet almost robbed a family of their husband and father. Medicine should treat patients not just reference ranges.

From Black & White to Nuanced Medicine

It absolutely blows my mind that as a naturopathic doctor I’ve had to defend TWO things endlessly in my career: 1. Testosterone Replacement Therapy 2. Now = GLP-1 meds and other peptides Meanwhile America keeps getting sicker. Patients stacking meds likes it out of Pez dispenser. I’d rather see the right patient on low-dose tirzepatide or retatrutide long-term than on: -blood pressure meds -diabetes drugs -pain meds and the list goes on. Same with TRT. The evidence is clear for properly selected patients, yet people still act shocked a naturopathic doctor would use hormones. Do I still think diet, lifestyle, sleep, exercise, stress reduction, and root-cause medicine matter? Absolutely. But pretending severely metabolically unhealthy patients are all going to meditate, meal prep deadlift, and colon cleanse their way out of disease is not reality. The GLP-1 data is still evolving and I’ll change my position if the evidence changes. But right now, the benefits for many patients appear to outweigh the risks by a long shot. Medicine should be about outcomes, nuance, and risk vs risk.

GLP-1s are dangerous!!! You know what’s also dangerous? Being 40 pounds overweight for 30 years. Chronic inflammation. Insulin resistance. Sleep apnea. Heart disease. Cancer risk. Medicine is risk vs. risk. Not risk vs. perfection.

Reta is crazy... may be the biggest breakthrough in obesity medicine we’ve ever seen. Phase 3: • 2,339 patients • 80 weeks • 70 lb average weight loss • 28.3% body weight reduction Nearly HALF of patients lost over 30% of their body weight. A few thoughts: -This is approaching bariatric surgery territory from a WEEKLY injection. -The most underrated finding may actually be the LOWEST dose. -The 4mg arm still lost ~19% body weight with fewer side effects and discontinuations. -Most patients don’t need “maximum possible weight loss.” They need something sustainable. -Retatrutide isn’t just stronger Ozempic. The glucagon agonism changes energy expenditure and fat oxidation in a very different way. The implications for: • obesity • fatty liver disease • inflammation • cardiometabolic disease • food addiction • longevity medicine …are massive. Most people still do not understand how much medicine is about to change over the next decade. I still really like Tirzepatide too, maybe more.

One of the biggest concerns with GLP-1 medications is muscle loss, and it's a valid one. Muscle mass is one of the strongest predictors of long-term health and longevity. Most people optimizing through exercise and hormone balance are in a good place, but it's something to watch closely when using these compounds. EDUCATIONAL & RESEARCH USE ONLY This content is provided for scientific discussion and educational purposes only. Some compounds discussed are not FDA-approved for human use and are not intended to diagnose, treat, cure, or prevent any disease. Not Medical Advice: This does not constitute medical advice or establish a doctor–patient relationship. Always consult a qualified healthcare professional for individualized guidance. No Sourcing: This channel does not sell, supply, or provide links to purchase research chemicals/peptides, and nothing here is intended to encourage self-experimentation. #MuscleMass #GLP1 #LongevityMedicine

Tirzepatide (Mounjaro/Zepbound) hits two receptors, GLP-1 and GIP, making it the most effective FDA-approved weight loss compound we have. One randomized controlled trial showed 22% body weight reduction. That's not anecdotal. That's the highest level of clinical evidence. EDUCATIONAL & RESEARCH USE ONLY This content is provided for scientific discussion and educational purposes only. Some compounds discussed are not FDA-approved for human use and are not intended to diagnose, treat, cure, or prevent any disease. Not Medical Advice: This does not constitute medical advice or establish a doctor–patient relationship. Always consult a qualified healthcare professional for individualized guidance. No Sourcing: This channel does not sell, supply, or provide links to purchase research chemicals/peptides, and nothing here is intended to encourage self-experimentation. #Tirzepatide #Mounjaro #WeightLossMedication