Joined April 2025
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The Gene Lay Institute of Immunology and Inflammation was founded on a generous gift @BrighamWomens @MassGeneralNews & @harvardmed.
give.brighamandwomens.org/ge…
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Gene Lay Institute of Immunology & Inflammation retweeted
Apr 28
Yesterday, the inaugural Gene Lay Institute (GLI) retreat was held at Harvard Business School. It was a pleasure to join the gathering of all GLI scientists. @GeneLayInst
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Gene Lay Institute of Immunology & Inflammation retweeted
A new Science #Immunology study addresses recent, conflicting findings on the role of #IL17 in #MultipleSclerosis, showing that IL-17A and IL-17 drive disease in EAE mouse model. @KuchrooLab scim.ag/3OtoiF7
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Gene Lay Institute of Immunology & Inflammation retweeted
Apr 25
An adaptive source of IL-17A/F is indispensable for EAE development! And B cell-derived IL-17 induces IL-23 signaling required to convert stem-like Th17 cells to encephalitogenic Th17 cells.
@GeneLayInst @MGBResearchNews @HarvardMed @BroadInstitute science.org/doi/10.1126/scii…
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Gene Lay Institute of Immunology & Inflammation retweeted
Apr 24
Review @NatImmunol @QuintanaLabHMS
Astrocyte-driven immunosuppression in the brain tumor microenvironment
nature.com/articles/s41590-0…
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Gene Lay Institute of Immunology & Inflammation retweeted
Apr 24
B cells are a critical adaptive immune cell type in the development of TH17 cell–mediated experimental autoimmune encephalomyelitis @SciImmunology
science.org/doi/10.1126/scii… @KuchrooLab @BrighamWomens
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Gene Lay Institute of Immunology & Inflammation retweeted
Apr 1
Review @JExpMed @Vignali_Lab @aamirbkbz
@KuchrooLab
Inhibitory receptor agonists: Emerging strategies in immune modulation
rupress.org/jem/article-abst…
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Gene Lay Institute of Immunology & Inflammation retweeted
Apr 1
Tim-3 restrains ILC2 function and attenuates airway hyperreactivity via NLK pathway @NatureComms @KECKSchool_USC
nature.com/articles/s41467-0…
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Gene Lay Institute of Immunology & Inflammation retweeted
In this review, Adam, Suhail, Kuchroo, and Vignali highlight the challenges and novel approaches to developing agonistic inhibitory receptor (IR)-targeted therapies to treat #autoimmunity and inflammatory disorders.
hubs.la/Q0493L5y0
#CancerFocus #LymphocyteBiology
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Gene Lay Institute of Immunology & Inflammation retweeted
Feb 27
Excited to share our new study defining the multicellular ecosystem of atopic dermatitis. Integrating >700k single cells from healthy and inflamed skin, we uncover disease-specific immune circuits linked to disrupted keratinocyte differentiation.
nature.com/articles/s41467-0…
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Gene Lay Institute of Immunology & Inflammation retweeted
Mar 4
New study, in collaboration with @Honda1Kenya, out now in @Nature. We show how a low protein diet drives a microbiota-dependent induction of thermogenic brown adipocytes via FXR & FGF21 pathways.
nature.com/articles/s41586-0…
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Gene Lay Institute of Immunology & Inflammation retweeted
Mar 23
Our latest work, with @MikaKivimaki lab, now online @alzdemjournals: we used single-cell and GWAS data to uncover genes in peripheral blood immune cells associated with Alzheimer’s disease.
doi.org/10.1002/alz.71282
@broadinstitute
@MGHMolBio
@MGBResearchNews
#Alzheimers
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Gene Lay Institute of Immunology & Inflammation retweeted
Mar 16
New work with @CarolineUhler, now online in @NatureComms! We developed TRIM, a multimodal framework integrating T cell RNA and TCR profiling to predict T cell responses to cancer treatment.
nature.com/articles/s41467-0…
@broadinstitute
@MGHMolBio
@MGBResearchNews
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Gene Lay Institute of Immunology & Inflammation retweeted
Jon Zurawski & Rob Bakshi had oral talk at ACTRIMS in San Diego integrating 7T LME and cortical lesions with novel CSF proteomic signatures in MS. Here’s link to Jon's talk: tinyurl.com/bmj44587. We also presented data on proteomic signatures in CSF linked to nasal foralumab.
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Gene Lay Institute of Immunology & Inflammation retweeted
Feb 23
1/2 New paper out now in Cell Systems @CellPressNews describing development of a deep learning framework to predict allergenic microbial proteases!
sciencedirect.com/science/ar…
@broadinstitute @MGHMolBio @MGBResearchNews
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Gene Lay Institute of Immunology & Inflammation retweeted
Was in Saudi Arabia in Dec with Saef Izzy & set up joint projects between the Ann Romney Center & KAIMRC. Projects include nasal anti-CD3 for MS, type 1 diabetes & heat stroke plus probiotics for MS. Here’s link to slides Saef showed in Feb in Riyadh; tinyurl.com/ynu23sfy
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Gene Lay Institute of Immunology & Inflammation retweeted
Published new concept of “Progression Independent of the Triggering Event” in Neurology Neuroimmunology & Neuroinflammation - shorturl.at/x4u5g. Was on cover. Multiple conditions cause CNS damage and trigger common mechanisms that identify common therapeutic approaches.
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Gene Lay Institute of Immunology & Inflammation retweeted
Jan 22
Spatial transcriptomics reveals altered communities and drivers of aberrant epithelia and pro-fibrotic fibroblasts in interstitial lung diseases
cell.com/cell-genomics/fullt… @CellGenomics @TheXavierLab @broadinstitute
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Gene Lay Institute of Immunology & Inflammation retweeted
Jan 22
Excited to share our latest study in Cell Genomics, combining single-nucleus RNA-seq, spatial transcriptomics, and histology to dissect the molecular determinants of lung fibrosis!
cell.com/cell-genomics/fullt…
#fibrosis #lung #ILD
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Gene Lay Institute of Immunology & Inflammation retweeted
Jan 26
If you haven’t registered yet, now's the time!
Some of the best minds in neuroimmunology, neuroscience, immunology AI — in one room.
RTN2026 | Oct 26–28, 2026 | Weizmann Institute
conferences.weizmann.ac.il/R…
@jonykipnis
@QuintanaLabHMS
@stevens1lab
@RejaneRua
@WeizmannScience
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Gene Lay Institute of Immunology & Inflammation retweeted
Jan 13
TFR cells are a dynamic and plastic cell subset, the differentiation of which is controlled by intrinsic and extrinsic programs that work together to form a feedback loop to control humoral immunity @NatImmunol @TheSageLab @BrighamWomens
nature.com/articles/s41590-0…
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