🚨Thrilled to share our latest work, published online today @Nature in which we decipher mechanisms underlying the enigmatic VEXAS syndrome - a huge team effort @MSKCancerCenter led by superstars @VarunNarendraMD @das_tandrila 🧵1/ nature.com/articles/s41586-0…

A terrific perspective from Ivan Dikic linkedin.com/feed/update/urn…)

@shouval_lab @SnehaPramod @hagargir and I reflect on the work of the ✨ TME community in a new review re fibroblasts in cancer @NatureCancer. 2025 was my yr to 🩵 the distraction of writing (IYKYK), so thx to all whose discoveries made this so gratifying. nature.com/articles/s43018-0…

RevMed just doubled overall survival in pancreatic cancer by using CypA-targeting molecular glues to potently drug oncogenic KRAS-ON, long deemed untouchable. One funny thing is that probably the most fundamental insight for daraxonrasib sits in a PNAS paper that's been cited merely 84 times. This showed that molecular glues can coax an endogenous protein to wrap itself around utterly featureless surface. The other is a 2017 Cell Reports paper (just 68 citations) on how Sanglifehrin A can be used to repurpose CypA's surface. A lot of the game-changing stuff seems niche and unglamorous at first. Greg Verdine is having a chembio Annus Mirabilis for his 2025-2026 streak: FOG-001, Daraxonrasib. He provided much of the foundational conceptual work behind taking out both Beta-catenin and KRAS*. *of course many others contributed immensely, but let's give some credit where credit is due!

Thrilled to share our new @NatureGenet paper! We mapped human skin at single-cell spatial resolution and found that anatomy is encoded in cell states and neighborhoods, led by PhD student @paularstrpo. Link: nature.com/articles/s41588-0… 1/9

Great work in Mol Cell from John Maciejowski's group delineating BAF dependent regulation of TREX1 and cGAS in micronuclei. Very important implications for immune responses to chromosome instability. cell.com/molecular-cell/abst…

Excited to announce a paper out today in @natgenet.nature.com identifying an approach to mitigate the risk of therapy-related myeloid malignancies in patients with cancer. Collaboration with @KellyLBolton @WashU and led by @IrenaeusChan & @PuZhang09980432 nature.com/articles/s41588-0…

Excited to share our new work uncovering a previously unknown mechanism identifying ANKIB1 as the E3 ligase that writes a critical new letter of the ubiquitin code central for immune signalling: K11-linked ubiquitin nature.com/articles/s41556-0…

Congrats @Walczak_Lab on this exciting new discovery!!🔥 👏 #ubiquitin

🎉 Congratulations to MSK physician-scientist @KarunaMDPhD and colleagues, who are part of an international team awarded a @CancerGrand grant — a prestigious global award providing up to $25M over five years to tackle some of the toughest challenges in #cancerresearch. The team will explore new ways to “rewire” cancer cells and prevent treatment resistance in #colorectalcancer, one of the leading causes of cancer-related deaths. Learn more: bit.ly/4d1GX4p

Cell-state dependent reliance on portions of metabolic networks is the topic of the other paper from @jules_stef published this week (!) in @MolecularCell cell.com/molecular-cell/full…

Out today in @cellcellpress new work from the lab led by Abby Xie and @jules_stef asks, when and why do cells use the TCA cycle?

My lab at MSKCC in New York is hiring for two positions. Join us at the frontier of functional genomics, studying fibroblast state transitions, combinatorial genetics, and ECM in disease. Please share with anyone who might be a good fit! (Mustache not required.)

Congrats @CalebLareau @MSKCancerCenter!!! 🔥 🔥

New preprint on technologies to scale up CRISPR screens. We use them to map 665,856 pairwise genetic perturbations and outline a path to comprehensive interaction mapping in human cells. We also introduce an approach for cloning lentiviral libraries with billions of elements.

Researchers @MSKCancerCenter @WeillCornell Discover PGBD5 Guides Normal Brain Development in Addition to Causing Cancers mskcc.org/news/researchers-d…

With ✨ trainees Frank, Anny & Zainab ⁦@MSKCancerCenter⁩ we share a current understanding of the pancreatic #TME ⁦@NatureRevCancer⁩. It was inspiring to reflect on progress by so many in the field over the last decade. Hope we did yall justice. nature.com/articles/s41568-0…

Congrats to our fellow @FiekeHoff for leading this systematic review looking at #HMA in #VEXAS now out in @BrJHaem! @bhavishap29 @KingsCollegeNHS @NIH onlinelibrary.wiley.com/doi/…

Check out our latest story science.org/doi/10.1126/scie…! Huge thanks to @GauravA_UK and the @bloodgenes lab for driving this work forward together with us. This was a great team effort with outstanding collaborators @_ruslansoldatov, @AbdelWahablab, and @AlexBickMDPhD.

1/7 New York's biomedical research enterprise is at an inflection point. Federal funding uncertainty has hit NY harder than any other state. Grant reviews are at 30% of prior levels. PhD programs cutting admissions 30-100%. A bold $6B proposal aims to change that. 🧵

Excited to share the first preprint of a new direction for our group. Led by the fearless duo of @arthurwchow and @hoyin_chu, our foray into computational protein design— 1/n biorxiv.org/content/10.64898…