@abledoc @__ice9 @farid__jalali Severe COVID-19: Immune system derails Contrary to what has been generally assumed so far, a severe course of COVID-19 does not solely result in a strong immune reaction. sciencedaily.com/releases/20…

The CDC made a public awareness ad about #MECFS in 2007. I’m not aware of a similar public health campaign since, despite millions affected and the lack of awareness that exercise can make people worse.

Topamax targets this plus migraine/intracranial pressure/CSF build up, which are all neurological complications of hEDS/MCAS But since Topamax is "neurology" med and not a "psychiatry" med, doctors won't prescribe it because they want chronic fatigue to be psychiatric. (But it worked well for me and I'm actually coming off of it because we got the pressure issue controlled). /endrant

I would leave upto @Tellit007 to guide on this with evidence including on Omega 3.

11 cancers on the rise in young people - scientists find first clue why it's happening bbc.in/494CmvB

Atherosclerosis Treatment Strategies Need to Change. Telmisartan-Metformin-Tadalafil can synergistically modify the atherosclerosis process.

Every oncologist and cancer researcher should watch this interview with @BenSasse: nytimes.com/2026/04/09/opini… Daraxonrasib, a “super poison for cancer,” shrank his metastatic pancreatic tumors by 76%, even though he says his skin feels and looks “nuclear.” When I learned of his diagnosis, I wanted him to get this drug (oral RAS ON inhibitor), which is poised to become first-line therapy in pancreatic cancer. I hope his experience on a clinical trial encourages more patients to enroll in studies, and pushes clinicians and researchers to keep advancing new therapies.

New! Online now: The gut microbiota alleviates depression by remodeling gut-brain energy metabolism dlvr.it/TRp62v

As a medical school professor, this is one of the most terrifying feedback loops I've seen in medicine. UC Davis researchers just published in Science showing how chronic kidney disease hijacks gut bacteria to destroy your kidneys FASTER. The mechanism: 1. Damaged kidneys increase nitrate in the colon 2. Nitrate supercharges E. coli to produce indole 3. Indole converts to indoxyl sulfate -- a kidney toxin 4. The toxin further damages kidneys 5. Repeat. Accelerate. Worsen. A vicious cycle where disease fuels its own progression through your microbiome. The breakthrough: blocking one enzyme (iNOS) stopped the entire cycle in mice. Human samples confirmed the same mechanism. This is metabolic dysfunction at its most insidious -- organs communicating through microbial metabolites, creating cascading damage. Targeting the gut environment, not just the microbes, may break the cycle entirely. Full breakdown coming on the Health Longevity Secrets podcast. Source: health.ucdavis.edu/news/head… #KidneyHealth #GutMicrobiome #MetabolicHealth #ChronicDisease #HealthLongevitySecrets

"COVID-19 patients show structural and functional changes in multiple cortical and subcortical regions compared to healthy subjects.. alterations were predominantly in frontal regions, temporal regions, parietal regions, limbic system, and subcortical nuclei. The microstructural and functional alterations in these regions may underlie impairment of a number of neurocognitive functions.. For acute COVID-19, whole-brain studies indicate lower GMV and functional activity (lower functional connectivity or ALFF), disruption of white matter fiber structures (lower FA or tract length), and increased tissue diffusivity (higher apparent diffusion coefficient or MD).. brain changes in long COVID-19 may be symptom-dependent, involving multiple neuropathological mechanisms, and do not present a uniform, stable global pattern.." Alterations in the brain cause alterations in personality. 'Widespread structural and functional brain alterations in COVID-19: a systematic review of MRI studies' academic.oup.com/cercor/arti…

This high school student just built a water filter that removes 96% of microplastics, without expensive equipment. In Warrington, Virginia, Mia Heller has built a filtration system that removes more than 95% of microplastics from drinking water. Her approach uses a magnetic liquid, ferrofluid, to pull tiny plastic particles out of the flow, without relying on traditional filter membranes.

Breaking: PolyBio Research Foundation today announced the launch of VIPER, the first large-scale program designed to rigorously validate diagnostic tests that measure SARS-CoV-2 persistence and other biological drivers of Long COVID: prnewswire.com/news-releases…

Reminder Scientists just found have a gut bacterium that can boost muscle strength 👀 Researchers have identified a gut bacterium called Roseburia inulinivorans that is associated with greater muscle strength and physical performance. The study, published in Gut, analyzed 124 participants and compared their gut microbiome with strength and fitness tests. People with higher levels of this bacterium showed stronger grip strength and better aerobic fitness, with older adults demonstrating up to 29% greater grip strength. In animal experiments, mice given the bacterium showed about a 30% increase in grip strength, suggesting gut microbes may influence muscle metabolism and the development of fast-twitch muscle fibers linked to power and strength.

Scientists just made 50-year-old skin cells behave like they’re 20 again. Researchers at the Babraham Institute in Cambridge have developed a groundbreaking method to reverse the biological aging of human skin cells by approximately 30 years, all while keeping them as fully functional adult skin cells. The team used a carefully controlled, short-term version of the Nobel Prize-winning Yamanaka reprogramming technique. By exposing adult skin fibroblasts to a specific set of reprogramming factors (the Yamanaka factors) for just 13 days—and then stopping the process early—they successfully “reset” many molecular markers of aging without pushing the cells all the way back to a stem cell state. After this brief treatment, the rejuvenated cells displayed a dramatically younger profile: their epigenetic clock (a measure of chemical tags on DNA that tracks biological age) and their gene expression patterns (the transcriptome) closely resembled those of cells from much younger individuals. Even more impressively, the cells behaved younger too. The treated fibroblasts produced significantly higher levels of collagen—the protein essential for skin firmness, elasticity, and wound healing—and they migrated faster to close an artificial “wound” in laboratory dishes compared to untreated older cells. The researchers also observed reversal of age-related changes in genes associated with diseases such as Alzheimer’s and cataracts, suggesting the technique could have broader therapeutic implications. While this work is still in its early stages and the precise mechanisms remain under investigation, the findings open exciting possibilities: one day, scientists may be able to selectively rejuvenate aging cells in the body to enhance tissue repair, improve healing, and potentially slow or mitigate some effects of age-related diseases—without the risks associated with fully reprogramming cells into stem cells. [Gill, D., Parry, A., Santos, F., Okkenhaug, H., Seale, M., Dobbs, L. J., Reik, W., & Ocampo, A. (2022). Multi-omic rejuvenation of human cells by maturation phase transient reprogramming. eLife, 11, e71624. DOI: 10.7554/eLife.71624]

💔 A Weight-Loss Drug… Helping the Heart Heal? What if a medicine made for weight loss could quietly help the heart recover after a heart attack? It may sound surprising, but scientists have discovered something interesting. Drugs like Ozempic might improve blood flow in tiny damaged blood vessels, possibly helping the heart heal after an attack. Even more surprising… these drugs are already known to reduce the risk of heart attacks and strokes, beyond just helping with weight loss. But here’s the twist—this possible “healing effect” is still in early stages and mostly tested in animals. Scientists are hopeful, but more research is needed to confirm it in humans.So now the real question is: Are we seeing the start of a medical breakthrough… or just the beginning of a mystery? Source: University of Bristol. (2026, March 4). Ozempic-like weight loss drugs may help the heart recover after a heart attack. ScienceDaily.

Zhang et al. show that maternal antibiotic-induced gut dysbiosis is associated with hypomyelination in offspring. Postnatal propionate supplementation rescues the deficit. shorturl.at/TX1o7

#LongCovid #MECFS

This review synthesizes current evidence on the concept of chrono-epigenetic nutrition, the interplay between diet-derived bioactives, circadian rhythms, and epigenetic reprogramming of neuroimmune cells. frontiersin.org/journals/nut…

A single dose of antibiotics can have lasting effects on your gut microbiome, with changes that last well beyond 4 years. Three types of antibiotics stood out for their long term disruptive impact (3 at left, Figure) @NatureMedicine nature.com/articles/s41591-0…

Glymphatic dysfunction links vascular pathology to Alzheimer’s biomarkers and cognitive decline "These findings highlight glymphatic dysfunction as a key mechanism linking vascular pathology with tau, inflammation and neurodegeneration, independent of Aβ uptakes." 🧠 link.springer.com/article/10…

This is BIG: New immunotherapy shows up to 99% drop in prostate cancer biomarkers. Researchers tested a new immunotherapy drug called VIR-5500 in men with advanced metastatic prostate cancer 👀 The treatment is a PSMA-targeting T-cell engager, designed to link immune T-cells directly to prostate cancer cells so the immune system can attack the tumor. In a Phase-1 clinical trial involving 58 patients with metastatic castration resistant prostate cancer, the highest dose produced striking results. 82% of patients saw their PSA cancer biomarker drop by at least 50%, 53% saw a 90% reduction and 29% experienced up to a 99% drop. The drug uses a “dual-masked” design that keeps it inactive in healthy tissues and activates mainly inside tumors, helping reduce severe immune side effects. While larger trials are still needed, the study suggests this next generation immunotherapy could open a new treatment path for prostate cancers that resist existing therapies.