The Guettler Lab @ICR_London studies cell signalling using biochemistry, structural biology and cell biology.

Joined October 2018
45 Photos and videos
Sebastian Guettler Lab retweeted
The UK's return to Erasmus in 2027 is fantastic news for young Britons & young Europeans. Erasmus opens up exciting opportunities to study or train abroad, boosting openness & cooperation. We're looking forward to welcoming young Britons to Germany!
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Sebastian Guettler Lab retweeted
“Our study [in @CD_AACR] suggests a new therapeutic approach to block metastasis before it starts, and help patients overcome triple negative #breastcancer,” said Dr. Vivek Mittal (@MittalLab) from @WCM_MeyerCancer and the @WCMEnglanderIPM. news.weill.cornell.edu/news/…
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Sebastian Guettler Lab retweeted
1/11 In @ScienceMagazine: A new perspective on how our intestines renew. Cells are not “pushed out” by crowding or die from apoptosis. Instead, cells play a mechanical tug-of-war, where weaker cells extrude, reframing gut renewal as force-regulated. science.org/doi/10.1126/scie…
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Many of us will still be reading posts on this platform, so here is one from us: we have an exciting Postdoc position available on the regulation of tankyrase in signalling and telomere maintenance. More information here: jobs.icr.ac.uk/vacancies/124…

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Sebastian Guettler Lab retweeted
Looking forward to attending new courses, scientific meetings and training events in 2025? View our events calendar to see what's taking place this year and secure your spot by registering now. We hope to see you there! #BiochemEvent ow.ly/KIBA50VmYBg
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Congratulations to Ben Broadway from our team for his excellent talk on his PhD project at this week’s fabulous #WNTUK2025 meeting in Oxford!
24 Mar 2025
The penultimate talk of the day is our Best selected PhD talk by Dr Ben Broadway from the @SGuettlerLab at @ICR_London presenting on CRISPR approaches to uncovering new tankyrase regulatory mechanisms in Wnt/B-catenin signalling. #WNTUK2025
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Sebastian Guettler Lab retweeted
Building on the content of R101, R for Biochemists 201 launches on 19 May! The course focuses on proteomic data analysis and uses modern data analysis concepts, packages and visualisations. Sign up and learn online at your own pace: ow.ly/32Jg50VmYAL
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Sebastian Guettler Lab retweeted
20 Mar 2025
We are less than a week away from the WntUK 2025 annual meeting in @UniofOxford @OxfordCancer To all our speakers, presenters and attendees we hope your preparations are going well and we look forward to seeing you Monday at @WorcCollegeOx Please use #WntUK2025 in your posts!

ALT I'M So Excited Gif GIF

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Sebastian Guettler Lab retweeted
9 Jan 2025
What better way to start 2025 than signing up for the #WNTUK2025 meeting on 24th March at @UniofOxford sponsored by @OxfordCancer @CambridgeBiosci! Early bird discount rates only available until Jan 17th and abstract deadline is Feb 1st! cancer.ox.ac.uk/news/oxford-…
12 Dec 2024
Registration and abstract submission is now open for the #WNT2025 meeting at @UniofOxford @WorcCollegeOx in March 2025 sponsored by @OxfordCancer and @CambridgeBiosci. Join using links below and lets showcase the best Wnt research the UK has to offer! oxforduniversitystores.co.uk…
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Sebastian Guettler Lab retweeted
12 Dec 2024
Registration and abstract submission is now open for the #WNT2025 meeting at @UniofOxford @WorcCollegeOx in March 2025 sponsored by @OxfordCancer and @CambridgeBiosci. Join using links below and lets showcase the best Wnt research the UK has to offer! oxforduniversitystores.co.uk…
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Sebastian Guettler Lab retweeted
13 Dec 2024
Amazing work by @munafomarzia who illustrated our @PauliGroup's findings on the "lock-and-key" mechanism that initiates #fertilisation👇
Unlocking fertilization 🗝️ out today @CellCellPress , @deneke_v , Blaha A & @PauliGroup @IMPvienna uncover a conserved protein complex on vertebrate sperm that recognizes distinct egg ligands in mammals and fish, thus enabling fertilisation. A #sciart and #scicomm 🧵
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Sebastian Guettler Lab retweeted
3 Dec 2024
🎉We’re delighted to announce that ICR's Dr Basil Greber has been selected for the @EMBO's 'Young Investigators Programme'. Dr Greber, Group Leader in Structural Biology is one of 27 life scientists who will be supported this year.
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Sebastian Guettler Lab retweeted
Follow WntUK and the latest network updates over on BlueSky!
4 Dec 2024
You can now follow us on BlueSky! Give us like, share, follow to build our WntUK network. bsky.app/profile/wntuk.bsky.… We are a network of UK based research groups with interests in the structural, molecular and cellular mechanisms of Wnt signalling in development and disease.
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Sebastian Guettler Lab retweeted
18 Nov 2024
We're excited to announce that conference registration will be opening soon! Visit our website for more details and stay tuned for updates! #BanffSNCCe Please share! event.fourwaves.com/banffsnc…
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Sebastian Guettler Lab retweeted
11 Nov 2024
A one day meeting on Friday 6th December covering all aspects (and scales) of Structural Biology.  Lots of talk slots to be selected from abstracts.  Deadline for abstracts is this Friday (15th Nov). bit.ly/4fDEqfZ
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Sebastian Guettler Lab retweeted
7 Nov 2024
We are pleased to announce that registration and abstract submission for the 2nd Wnt UK meeting in 2025 at @UniofOxford @WorcCollegeOx sponsored by @OxfordCancer is now open below! REMEMBER we are encouraging applications for the new invited ECR talk! cancer.ox.ac.uk/news/oxford-…
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Sebastian Guettler Lab retweeted
6 Nov 2024
My co-first author paper now out in @Nature SWR1 specifically exchanges H2A/H2B dimers for Htz1/H2B dimers in nucleosomes. Here we show double dimer exchange can be processive, explaining how SWR1 ‘proofreads’ dimer identity in a nucleosome. nature.com/articles/s41586-0…
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