@WestHam Fan ⚒ 🏴󠁧󠁢󠁥󠁮󠁧󠁿 | Accidental Centrist I Pro-Pragmatism and Real World Outcomes I Anti-Ideologues.

Joined February 2021
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The only things that have ever had a noticeably positive, albeit temporary, effect on my Long Covid symptoms are things that either reduce histamine & mast cell activity or force blood vessel constriction / dilation (i.e. flush niacin, cold/hot water immersion etc).
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What I think is the most plausible 'root cause' explanation for Long Covid – it is that some ppl are more prone to mast cell over-activity & inflammatory response – which Covid massively triggers & exacerbates – which then grates at nerves & connective tissue, incl blood vessels
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Fits with what we know of Covid. It is very inflammatory (via multi mechanisms- viral persistence, inducing autoimmunity etc), triggers mast cells, alters gene expression & leaves a greater long-term mark on those with connective tissue problems (all scientifically evidenced).
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Based on the experience of the last 6 years, I am extremely sceptical about bold claims like this. We've been here before a dozen plus times. Hasn't worked out too well.
Die bisher beste Long Covid Studie wurde nun veröffentlicht, mit überraschenden Ergebnissen die neue Therapieansätze ermöglichen. Vereinfacht gesagt: Long Covid wird (in den untersuchten Bereichen) von Autoantikörpern im Blut verursacht, die dann sehr wichtige Teile des Gehirns angreifen und eigentlich alle Symptome erklärbar machen. Wichtige Erkenntnis: Long Covid Patienten dürfen keinesfalls Blut spenden denn es scheint übertragbar zu sein über jene Autoantikörper im Blut! Toller Artikel, verständlich geschrieben: healthrising.org/blog/2026/0…
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Shaney Wright retweeted
My post about the @WIRED story by @AlanLevinovitz clocked in at 3,000 words--not quite half the length of the story itself. Sorry!!--I tried to keep it shorter, but there was just so much to say. And more likely to come. virology.ws/2026/06/09/trial…
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Shaney Wright retweeted
The idea that fatigue can't have a biological cause is utterly bizarre. It's probably 1 of the most consistent symptoms of an immune activating event, e.g. infection, TBI, allergies, menstruation, as well as multiple chronic immune activating conditions, e.g. autoimmune diseases
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Shaney Wright retweeted
Replying to @AlanLevinovitz
Could you please post a link to the study you are referring to that apparently suggests 91% LC patients recover within a year? This contradicts 4 other studies I’m aware of regarding long covid longevity, so I’d like to read & critically appraise the paper you refer to. Thank you
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Shaney Wright retweeted
🫀🧠 When I see new studies and papers coming out on #POTS and #dysautonomia in scientific literature, I am so glad to see this progress! I remember a time when it was one or two papers per month, but now new papers are coming out almost daily! There is a huge need to advance the field: the more, the better! 🦠 Here is a new study (not yet peer-reviewed) that demonstrates impaired immune response in patients with post-COVID POTS, compared to people who recovered from COVID-19, in the form of increased T cell monocytes and proinflammatory cytokines. 📢 My take on this: This study should be replicated in people with POTS unrelated to COVID-19. pmc.ncbi.nlm.nih.gov/article…
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Shaney Wright retweeted
Neue Studie (Boston University, 2026): hEDS ist kein Ein-Gen-Defekt. KI-Genomanalyse zeigt Varianten in 3 Systemen – Kollagen, Immunsystem (HLA bei ~75 %!) & Mitochondrien. Das erklärt, warum hEDS so oft mit MCAS & Dysautonomie auftritt. #hEDS #MECFS #MCAS
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Around the 6th study to replicate the finding that people with Long Covid have significant, measurable microvascular alteration vs controls, as seen by analysing the retina. Endothelial dysfunction & cerebral hypoperfusion are hallmarks of Long Covid, evidenced over & over again.
Children with Long COVID had measurable retinal microvascular changes. buff.ly/fPSg320 In 74 kids ages 7–17, scans found wider arterioles, wider venules, and a higher A/V ratio, consistent with endothelial dysfunction. The eye may help track pediatric Long COVID.
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Shaney Wright retweeted
Glad to be a part of the consensus-2 diagnostic criteria for mast cell activation syndrome #MCAS and this new review. MCAS is comorbid with #dysautonomia and #EDS, and the most frequent comorbidity of MCAS is #POTS (from our prior study). degruyterbrill.com/document/…
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Shaney Wright retweeted
Alan, you say it would be "great to know" more about these approaches. Then why did you fail to mention the fraudulent trial of the Lightning Process, with a 3,000-word correction, that was published in a Lancet journal? And the Gupta trial in Scandinavia with null early results?
Zeynep — this is not like TB (or cancer, or HIV, or any of the other analogized conditions), because there is no "long Covid" in the first place. There's an extremely vague definition that could apply to a range of conditions, from post-ICU syndrome to basically every PAIS that's out there. Much of the article is dedicated to discussing the definitional problems, as well as the problems that creates for studying "the" condition in the first place. The piece isn't saying that "mind-body" therapies work, or don't work, for long Covid, or any PAIS. It's saying that right now there IS no single entity we can call "long Covid," there's just vague definitions of a family of syndromes and symptoms, which result in everything from extremely moderate to very severe illness. Equally important, and also the point of the article: A subset of very, very ill people — and a larger subset of mild/moderate — attribute their recovery to mind-body interventions. Was it spontaneous remission? Was it "placebo"? Was it...something else? It would be great to know! But that patient group, specifically, has been of zero interest to researchers, and are actively ostracized by the advocacy world. No one studies *recovered* LC patients who were severely ill and attribute their recovery to mind-body therapies, as, for example, they do over in ALS where the very, very few spontaneous remissions are of great interest to researchers. Instead, people like Larson and Lupi are told they are full of shit, or were never really sick, or are wrong about what caused their recovery. That's what the article is about. Other articles can discuss other things! But those are the dynamics and themes I address. They are important. Failing to address them is holding back research on a very heterogenous and poorly defined set of conditions.
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Shaney Wright retweeted
1) Impressive paper from Iwasaki’s lab pointing at autoimmunity in a subgroup of Long Covid patients. They replicated previous experiments of human antibody transfer causing symptoms in mice. A couple of findings that stand out…
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Shaney Wright retweeted
LC/Allergic Conditions in Children Adults COVID-19 infection was associated with significantly increased hazard ratios for all six allergic conditions in the full cohort. asthma, rhinoconjunctivitis, food medication allergies urticaria, atopic dermatitis sciencedirect.com/science/ar…

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Shaney Wright retweeted
These findings are replicated in a 2nd independent study with persistence of the effect of the autoantibodies when transferred even 2 years later sciencedirect.com/science/ar…
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Shaney Wright retweeted
Important #LongCovid finding of auto-antibodies in patients directed to neural tissue, and then, by transferring the antibodies, recapitulated the disease symptoms in mice @CellCellPress @VirusesImmunity @putrinolab cell.com/cell/abstract/S0092…
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Shaney Wright retweeted
After I asked for a correction for a paper's categorical statement about what is "generating" functional neurological symptoms, @ZacharyGrinDPT demanded I apologize to the authors. However, the authors immediately said they will revise the problematic sentence. 1/
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RT @ahandvanish: #LongCovid has not decreased from 2020-2024. Prevalence is 13-23% of US population, increasing 0.4%-1.5% every 3 months.…
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