our work mapping the molecular cellular progression of lung damage in severe COVID-19 is out @NatureComms ! A covid side project that turned into a labour of love over the years & really happy @THJimmyLee & Sam pushed this collaboration over the line. nature.com/articles/s41467-0…

Preprint alert! 🚨 Our manuscript on Exome sequencing and analysis of 44,028 British South Asians (Genes & Health) is now live @medrxivpreprint! Among great findings, and I’m thrilled to highlight the pieces I worked on 🧵 doi.org/10.1101/2025.06.05.2…

How does tumour heterogeneity arise? How can we predict cancer cell plasticity? In 2 studies, we trace #glioblastoma heterogeneity to a spatial cancer cell trajectory w. atlassing bit.ly/4mkrWgs & predict plasticity w. snRNA/ATAC deep learning bit.ly/3FbI6Ic 🧵

I’m happy to share that our scCellFie manuscript is finally on bioRxiv — a project that was an amazing opportunity to return to my roots in metabolism! We infer metabolic activity from single-cell & spatial transcriptomics 🧬 Read the pre-print here👇 📄 doi.org/10.1101/2025.05.09.6…

⭐ Huge NEWS for the Human Cell Atlas! ⭐ The Human Cell Atlas signs a partnership with the UNESCO. @humancellatlas @UNESCO Tremendous recognition of the Human Cell Atlas (HCA) project's vision, ethical standards, and global impact. UNESCO, renowned worldwide for promoting open science, educational development, and ethical frameworks, now formally acknowledges the HCA’s efforts and mission. This collaboration honors HCA’s commitment to building a truly representative atlases of the global human population, underscoring our dedication to inclusivity, openness, and equity in scientific research. As we move forward into the next exciting phase, developing also disease-specific atlases, this partnership with the UNESCO will empower us to tackle significant global health challenges, including diseases endemic to regions and worldwide pandemics. Today, I'm feeling even prouder to be part of the HCA! 🧡 Looking forward to contributing further to building this remarkable effort in an inclusive, equitable, and truly global manner. humancellatlas.org/news/the-…

our work mapping the molecular cellular progression of lung damage in severe COVID-19 is out @NatureComms ! A covid side project that turned into a labour of love over the years & really happy @THJimmyLee & Sam pushed this collaboration over the line. nature.com/articles/s41467-0…

happy to see our cell2fate model out at @naturemethods. It is a completely new take on RNA velocity to disentangle complex cell trajectories from scRNA data & we have some very cool applications coming up! nature.com/articles/s41592-0…

Thrilled to share LUNA🌕 – our new generative AI model that reassembles tissues from dissociated cells! Think of it as AlphaFold for cells 🧬 From the MERFISH mouse brain atlas to the scRNA-seq atlas & Slide-tags datasets, LUNA is widely applicable. Bringing us closer to virtual tissue modeling 🧠 Super proud of @yistyu – what a way to start her PhD!🙌 And huge thanks also to all our collaborators @thecekbote @stephanedascoli @pafrossard Nikita Morozov Jiashuo Fan Curious about LUNA? Check out our paper Tissue Reassembly with Generative AI: biorxiv.org/content/10.1101/…

In our Jan issue: Entering the #spatial age of parasite #genomics, authored by @SarahBuddenborg & @stephenrdoyle highlighting Simone Haeberlein & colleagues’ @NatureComms article. #Transcriptomics #Helminths #Fasciola #hepatica @sangerinstitute @jlugiessen cell.com/trends/parasitology…

Final talk now in the #HCA2024Asia neuro track is from @THJimmyLee on cellular vulnerabilities in ALS