Immunology, Laboratory Medicine and Pathobiology Lab | UofT/USC/UHN/St Michael's/Buck Institute | Immunometabolism, Mechanoimmunology, Astroimmunology, Aging
Joined March 2023
- Tweets 65
- Following 256
- Followers 141
- Likes 123
Photos and videos
Humanity is traveling further into #space. Here, just published in @NatureAging , we discuss parallels between #spaceflight and #aging.
@Furman_Lab
@BuckInstitute
@UHN
rdcu.be/fbymi
nature.com/articles/s43587-0…
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Dan and Shawn Winer retweeted
Blast off! Buck scientists make the case for space as a model for accelerated aging. nature.com/articles/s43587-0…
@NatureAging
@furmanbios
@winer_imm_lab
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Gut microbiota-derived metabolites as immune modulators in aging and a... sciencedirect.com/science/ar…
Nearly everything you need to know on gut microbiome metabolites, immunity and aging in a single review!
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Dan and Shawn Winer retweeted
Jan 30
B cells promote CD4 T cell aging and decline in health-span parameters through intercellular communication and nutrient sensing @SciImmunology @Winer_Imm_Lab @UofT
science.org/doi/10.1126/scii…
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Dan and Shawn Winer retweeted
Jan 30
🚨 New publication alert! Research from @UHN reveals a mechanism behind why the immune system declines with age.
B cells—best known for producing antibodies—play a critical role in driving the aging of T cells, fighters of infection.
🔗 Read more: uhnresearch.ca/news/aging-an…
ALT Fluorescence image of T cells and B cells in the spleen. (Image: Winer Lab)
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B cells drive CD4 T cell immunosenescence and age-associated health decline | Science Immunology science.org/doi/10.1126/scii…
More than 10years of work from our lab showing that B cells are major players in T cell aging. Thank you to the team!
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Dan and Shawn Winer retweeted
16 Oct 2025
🚀 Excited to share our new Nature Reviews Immunology paper: “Astroimmunology: the effects of spaceflight and its associated stressors on the immune system.” We explore how space environment impacts impacts immunity, vital for Moon & Mars missions.
doi.org/10.1038/s41577-025-0…
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Dan and Shawn Winer retweeted
16 Oct 2025
Review out in Nature Reviews Immunology: Astroimmunology—how spaceflight reshapes immunity. I’m a co-first author. Co-firsts: Daniel Winer & Huixun Du. Corresponding/senior: Winer, Mason, Choukér & Crucian. @mason_lab doi.org/10.1038/s41577-025-0… #Astroimmunology
16 Oct 2025
Astroimmunology: the effects of spaceflight and its associated stressors on the immune system bit.ly/3J9Oodi
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Dan and Shawn Winer retweeted
17 Oct 2025
"Astroimmunology: the effects of spaceflight and its associated stressors on the immune system." Excited for this @Nature Reviews Immunology paper! Summarizes the past few decades of spaceflight and immunology and next steps: nature.com/articles/s41577-0… bravo @KJangkeun @Marissa_R_Burke from our lab and Winer, Choukér & Crucian
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Dan and Shawn Winer retweeted
30 Aug 2025
It is my pleasure to share this in-depth investigation of the gut-brain axis. Hope you will enjoy this humble exploration of new hypotheses--a process I truly enjoyed.
29 Aug 2025
Is brain/gut axis a superhighway for immune response to #Alzheimers? Study @CellReports shows immune cells use that route in mouse models. Feeding animals a high fiber diet reduced AD-related frailty. Congrats @Winer_Imm_Lab @pmakhijani16 @JKAndersenBuck
buckinstitute.org/news/the-g…
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Dan and Shawn Winer retweeted
2 Sep 2025
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Dan and Shawn Winer retweeted
29 Aug 2025
Is brain/gut axis a superhighway for immune response to #Alzheimers? Study @CellReports shows immune cells use that route in mouse models. Feeding animals a high fiber diet reduced AD-related frailty. Congrats @Winer_Imm_Lab @pmakhijani16 @JKAndersenBuck
buckinstitute.org/news/the-g…
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Dan and Shawn Winer retweeted
23 Jan 2025
📢New Recommended Reading📖
Substrate stiffness dictates unique doxorubicin-induced senescence-associated secretory phenotypes and transcriptomic signatures in human pulmonary fibroblasts Huixun Du & Daniel A. Winer (@Winer_Imm_Lab) et al.
link.springer.com/article/10…
#tissuestiffness #doxorubicin #transcriptomics #senescentcells #senescenceassociatedsecretoryphenotype
23 Jan 2025
Many age-related diseases involve fibrosis. Study in @GeroScienceAGE shows mechanical forces shape #cellularsenescence and related secretory phenotypes. Researchers in Winer lab ID’d unique high-stiffness-driven secretory protein profiles
link.springer.com/article/10…
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2 Dec 2024
doi.org/10.1186/s12979-024-0… Great review on the role of antibodies in obesity and aging pathology.
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22 Nov 2024
Substrate Stiffness Dictates Unique Doxorubicin-induced Senescence-associated Secretory Phenotypes and Transcriptomic Signatures in Human Pulmonary Fibroblasts biorxiv.org/content/10.1101/…
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Dan and Shawn Winer retweeted
11 Sep 2024
The inflammaging clock strikes IL-11! @ImmunityCP @Winer_Imm_Lab
cell.com/immunity/fulltext/S…
Spotlight on @Nature
nature.com/articles/s41586-0…
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Dan and Shawn Winer retweeted
1 Sep 2024
This is our first major paper of the lab showing early life modulation of T1D development, linked to maternal IgA deficiency. Super proud of the work twitterless Erinnand Luisa have done!
31 Aug 2024
Maternal humoral factors modulate offspring gut immune homeostasis to mitigate diabetes development @SueYTsai1
doi.org/10.1101/2024.08.28.6…
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13 Jun 2024
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Dan and Shawn Winer retweeted
11 Jun 2024
Papers from our Space Omics and Medical Atlas (SOMA) package, built upon the extraordinary data from the @inspiration4x mission with @SpaceX are now coming online. With more civilian crews going to space, this is truly the opening of the Second Space Age: nature.com/articles/s41586-0…
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