NEW preprint led by @ElyssaCampbell4 with @suscla1, where we used MOFA to uncover the rapid 3D chromatin and transcription changes triggered by androgens in prostate cancer. (1) Check it out here: biorxiv.org/content/10.1101/…

Very happy to see this work finally online!! It was a long haul to generate the transgenic mice. A lot of excitement and learning to use spatial transcriptomics for characterization. Hope this model will help understand the tumor suppressor role of FOXA1 in prostate cancer.

In a phase 1 study of the oral p53 reactivator rezatapopt in heavily pretreated patients with TP53 Y220C–mutated solid tumors, the most common adverse events were nausea and vomiting, and the overall response was 20%. Full PYNNACLE study results: nej.md/3OIQC5P Science behind the Study: Restoring Function to a Variant of p53 in Solid Tumors nej.md/3N0pQW8

Excited to share our new FinnGen single-nucleus multiome preprint! 🧬 We profiled ~10M PBMCs (snRNA-seq snATAC-seq) from 1,108 Finnish donors to map how genetic variants drive complex disease through chromatin and gene regulation 🧵👇 🔗 Link: medrxiv.org/content/10.1101/…

Very happy to finally present our work! “𝘚𝘵𝘢𝘯𝘥𝘢𝘳𝘥𝘪𝘻𝘦𝘥 𝘮𝘦𝘵𝘳𝘪𝘤𝘴 𝘧𝘰𝘳 𝘢𝘴𝘴𝘦𝘴𝘴𝘮𝘦𝘯𝘵 𝘢𝘯𝘥 𝘳𝘦𝘱𝘳𝘰𝘥𝘶𝘤𝘪𝘣𝘪𝘭𝘪𝘵𝘺 𝘰𝘧 𝘪𝘮𝘢𝘨𝘪𝘯𝘨-𝘣𝘢𝘴𝘦𝘥 𝘴𝘱𝘢𝘵𝘪𝘢𝘭 𝘵𝘳𝘢𝘯𝘴𝘤𝘳𝘪𝘱𝘵𝘰𝘮𝘪𝘤𝘴 𝘥𝘢𝘵𝘢𝘴𝘦𝘵𝘴” Spatial transcriptomics promises deep insight into tissue architecture - but inconsistent data quality across labs and platforms has been a major barrier. A new study from a global consortium addresses this by releasing the Spatial Touchstone (ST): a harmonized, multi-site, multi-platform dataset using six tissue types and two widely imaging used technologies. We introduce SpatialQM, an open-source quality-control software, and a public repository, Spatial Touchstone Portal (STP), that hosts ~33M cells and ~7B transcripts. With standardized metrics for sensitivity, reproducibility, signal-to-noise, false discovery rates, and cell-type annotation, this framework gives labs a way to benchmark and compare spatial transcriptomics data reliably. This effort sets a foundation for more robust, reproducible spatial-omics research — and helps unlock cross-study comparability across institutions and platforms. I’m incredibly thankful to my amazing collaborators across the globe and an special shout out to my dear friends @DrJasPlummer and @mason_lab and their super amazing teams for literally working they brains out to make this happen. Felipe, Jiwoon , David, Luke, Maycon, Yutian, Arjumand, Hannah, Kellie, Alex, Lisa, Alicia, Roberto and many more! @WeillCornell @StJudeResearch nature.com/articles/s41587-0…

SeqManager: A Web-Based Tool for Efficient Sequencing Data Storage Management and Duplicate Detection. #SequencingData #DataStorage #DuplicateDetection #Genomics #Bioinformatics @BioinfoAdv academic.oup.com/bioinformat…

How does the evolution of the cancer epigenome contribute to immune evasion? We investigated this in colorectal cancer, where we found that immune evasion follows a ‘Big Bang’ evolutionary pattern, initiated right at transformation: nature.com/articles/s41588-0…

Too many men die of prostate cancer. We miss you John. We discovered a new way of attacking androgen receptor driven prostate cancers that will lead to new therapeutics. This was a wonderful collaboration with @li_haolong and Felix Feng (rest in peace). doi.org/10.1038/s41588-025-0…

This is what the last five years have been about! Incredibly proud to share our new paper in Nature Genetics: “Transcription Factor Switching Drives Subtype Specific Pancreatic Cancer.” Thank you @JCarrollLab @PancreaticCanUK @CRUK_CI nature.com/articles/s41588-0…

Chromatin organization is measured in single cells using droplet microfluidics go.nature.com/3NCqwO1 rdcu.be/eNah5

🚀 Excited to share our latest @biorxivpreprint by @CEStieger We unveil TRACERs - Transcriptional Regulation via Active Control of Epigenetic Reprogramming - a new small-molecule-based induced-proximity modality that silences transcription factors by recruiting endogenous corepressor complexes for locus-specific repression. biorxiv.org/content/10.1101/…

Most transcription factors were historically considered undruggable. But some innovative biotechs are changing all that & big pharma is starting to pay attention. Out now in @NatureBiotech nature.com/articles/s41587-0… Ivws w/: Flare Tx, Quantro Tx, Genentech, Sapience Tx & Ten63 Tx

New in Nature Reviews Genetics: my Review on how advanced genomic technologies are redefining cellular reprogramming: mapping trajectories, dissecting chromatin dynamics, lineage tracing & synthetic circuits to push the boundaries of cell identity. rdcu.be/eLv1Z

Ever wondered how the 3D shape of DNA influences nucleosome spacing along chromatin? Dr. Vijay Ramani from the Gladstone Institute, will reveal fresh, unpublished insights on this topic, featuring a new method – LASSI – that tracks single-molecule sequence interactions in 3D.

We like to introduce map3C, developed by Joseph Galasso, that drastically improves the mapping and contact calling performance of snm3C-seq and now enables accurate 3D genome modeling. map3C was developed in collaboration with @jernst98 and Frank Alber biorxiv.org/content/10.1101/…

Here's the link to the system, try it! qedscience.com/ @qedScience

Science leader job in the UK 🤩

Choose your human genome reference wisely. #HumanGenome #ReferenceGenome @naturemethods #TechnologyFeature nature.com/articles/s41592-0…

Comprehensive benchmarking with guidelines for analyzing transposable element-derived RNA expression. #TransposableElements #Benchmarking #RNAexpression @biorxivpreprint biorxiv.org/content/10.1101/…