Ph.D student at @LabVanni || Computational Bio-physics/chemistry || Intrinsically disordered proteins || Biomolecular Phase separation.
Joined April 2020
- Tweets 284
- Following 927
- Followers 316
- Likes 2,204
2 Photos and videos
Ashutosh Kumar retweeted
New preprint in which we built and simulated full-length models of α-Synuclein fibrils to reveal how the fuzzy coat mediates selective binding of peptides to amyloid fibrils
Work led by Carlos Pintado-Grima in a nice collaboration with Salvador Ventura's lab
Full-Length Molecular Models of Brain-Derived α-Synuclein Fibrils Reveal a Fuzzy-Coat-Mediated Mechanism for Selective Peptide Binding biorxiv.org/content/10.64898… #biorxiv_bioinfo
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Ashutosh Kumar retweeted
Jan 8
Can we design mutations that predictably bias proteins towards desired conformational states?
Today in @ScienceMagazine, we introduce Conformational Biasing (CB), a simple and scalable computational method that uses contrastive scoring by inverse folding models to identify conformation-biasing mutations.
science.org/doi/10.1126/scie…
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Ashutosh Kumar retweeted
(Part 1/2) Excited to share that our work, led by PhD student Keerthivasan Muthukumar (@kvasan452) and postdoc Dr. Dinesh S. Devarajan (@Dsundara993), is now published in PNAS (pnas.org/doi/10.1073/pnas.25…).
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Ashutosh Kumar retweeted
7 Nov 2025
Dystonia-associated Torsins sustain CLCC1 function to promote membrane fusion of the nuclear envelope for NPC biogenesis biorxiv.org/content/10.1101/… #biorxiv_cellbio
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Ashutosh Kumar retweeted
13 Sep 2025
I am hiring at the PhD or Postdoc level. I am looking for motivated candidates willing to work on a challenging project at the frontiers of what we understand of protein colloidal stability.
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Ashutosh Kumar retweeted
1 Aug 2025
Our collaborative work "The #Martini3 #Lipidome: Expanded and Refined Parameters Improve Lipid Phase Behavior" is now published in #ACSCentralScience! 🎉
📄 Read: pubs.acs.org/doi/10.1021/acs…
💾 GitHub: github.com/Martini-Force-Fie…
#MolecularDynamics #Biophysics #Simulations #Lipids
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Ashutosh Kumar retweeted
16 Jun 2025
If heterochromatin is really a liquid-like condensate, why is it not spherical?
We investigated whether mechanical interactions between a condensate and a fiber network can explain the variety of morphologies seen in phase-separated nuclear compartments.
biorxiv.org/content/10.1101/…
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Ashutosh Kumar retweeted
23 May 2025
Excited to share the new work from the Carvalho lab
@Dunn_School! 🎉This was part of my PhD & a collaboration with the @LabVanni
& Ernst labs!
Big thanks to everyone involved! 🙌
Read more: doi.org/10.1083/jcb.20240903… (1/2)
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Ashutosh Kumar retweeted
5 May 2025
Join our interdisciplinary team developing computational approaches to understand and engineer biomolecular condensates. We’re looking for a postdoc—please apply or share with interested persons! 👩🏽💻💧🧬 puwebp.princeton.edu/AcadHir…
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Nature research paper: Structural basis of lipid transfer by a bridge-like lipid-transfer protein
go.nature.com/4itODM4
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Ashutosh Kumar retweeted
24 Mar 2025
Martini 3 - IDP is out! Improved parameters for disordered proteins, great work from Liguo Wang: nature.com/articles/s41467-0…
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Ashutosh Kumar retweeted
14 Feb 2025
ABHD17 enzymes remove fatty acids from #membrane proteins like NRas. New work from Holme, Sapia, @LabVanni, Conibear @UBC et al. show that their activity depends on two mobile regions: an S-acylated N-terminal helix and a loop. hubs.la/Q036MbQS0
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Ashutosh Kumar retweeted
3 Jan 2025
After some work, we’ve now made the @github for our #Martini3 #LNP models and protocols publicly available: github.com/Martini-Force-Fie…
We also have a new @ChemRxiv with some minor updates: chemrxiv.org/engage/chemrxiv…
#LipidNanoparticles #MD #DrugDelivery #mRNA #Simulation
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Ashutosh Kumar retweeted
6 Dec 2024
In collaboration with @BanerjeeLab_UB, we dive a little deeper into the microscopic interactions and sequence patterns shaping condensate activation energies pubs.acs.org/doi/10.1021/acs…. For more context, see also our prior work science.org/doi/10.1126/scia…
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Ashutosh Kumar retweeted
6 Dec 2024
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Ashutosh Kumar retweeted
6 Dec 2024
Super excited to preprint our work on developing a Biomolecular Emulator (BioEmu): Scalable emulation of protein equilibrium ensembles with generative deep learning from @MSFTResearch AI for Science.
#ML #AI #NeuralNetworks #Biology #AI4Science
biorxiv.org/content/10.1101/…
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Ashutosh Kumar retweeted
27 Nov 2024
We did this crazy project where we tried to see if proteins could interact with their mirror image ligand. Seems impossible when proteins need to form 3D structures to interact. But what about if the interaction remains disordered???
nature.com/articles/s41586-0…
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Ashutosh Kumar retweeted
28 Nov 2024
A coarse-grained model of disordered RNA for simulations of biomolecular condensates biorxiv.org/cgi/content/shor… #biorxiv_biophys
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Ashutosh Kumar retweeted
21 Nov 2024
@JiaqiZhuDartmth and I are excited to share our new manuscript characterizing the conformational ensembles of covalent adducts formed by a disordered protein and small molecule drugs
biorxiv.org/content/10.1101/…
Code Ensembles:
github.com/paulrobustelli/Zh…
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Ashutosh Kumar retweeted
7 Nov 2024
Entropy can contribute to stability of RNA clusters! Find out more from Dilimulati Aierken’s new paper! Thrilled to have this work published @JCIM_JCTC pubs.acs.org/doi/10.1021/acs…
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