Cancer Evolution and Genome Instability, Lung Oncologist Air Pollution and Drug Resistance Fair Weather 🚴
Joined January 2015
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491 Photos and videos
Charles Swanton retweeted
Jun 13
What if we could predict cancer 5 years ahead and prevent it? A new landmark study shows the way
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Charles Swanton retweeted
Jun 12
Getting to the root of age-related diseases. By studying a rare accelerated aging genetic disorder, gain-of-function mutations of DNMT3A were found to be causal.
DNA hyper-methylation was then linked to stem cells dysfunction and multiple age-related diseases (blood, bone, metabolic). Work in mice and humans. @NatureGenet
nature.com/articles/s41588-0…
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Charles Swanton retweeted
🔥14-protein plasma signature predicts lung cancer >5 years before diagnosis
🆙 @CellCellPress
☑Analysis of 48,000 samples; validated across 8 cohorts
🎯Anti-IL-1β therapy stratified by signature lowers NNT for prevention
🎙Dr. Tej Pandya @CharlesSwanton
#LCSM @OncoAlert @Larvol
cell.com/cell/fulltext/S0092…
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Charles Swanton retweeted
Jun 9
The primary is the source of first progression in >50% of cases of #lungcancer patients, and TRACERx showed us that in 32% of NSCLC the primary polyclonally seeds metastases. In our @IASLC consensus, now in JTO shorturl.at/GzAe2, makes the case for eradicating it with #radiotherapy. The EGFRm phase III data are the most compelling OS 34.4 vs 26.2 months with TKI RT. There are still unresolved questions in the non-AGA population. We are opening the phase III PRIME-LUNG trial shorturl.at/26apO @TROGfightcancer @TOGAANZ to answer this question! #radonc
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Charles Swanton retweeted
Thanks, this 14-protein plasma signature predicting IL-1β responsiveness years ahead of lung cancer diagnosis is genuinely exciting. How do you see it reshaping early detection strategies for people across all risk levels?
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Charles Swanton retweeted
Jun 4
The striking part isn’t just that a 14‑protein panel can flag lung cancer risk >5 years out, it’s that the signal is so IL‑1β‑centric. That neatly retrofits the CANTOS “accident” where canakinumab cut lung cancer incidence and mortality. We’re basically watching systemic inflammation turn the lung microenvironment pro‑tumor long before a nodule appears on CT. The next step isn’t more imaging, it’s immunoprevention trials in the high‑signature group.
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Charles Swanton retweeted
Jun 4
A very impressive study for how we could prevent lung cancer more than 5 years before it is diagnosed. Using machine learning, discovery of a 14-plasma protein signature of risk that predicts responsiveness to an antibody therapy to interleukin, IL-1β
Validated across 8 cohorts
@CellCellPress @CharlesSwanton
cell.com/cell/fulltext/S0092…
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Charles Swanton retweeted
Jun 4
If helpful to understand the importance of this study, I made an infographic with @NotebookLM
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Charles Swanton retweeted
May 22
Remarkable is an understatement!
#ASCO26 7-yr update (Abstract 8502, CROWN): 1L lorlatinib in advanced ALK NSCLC — median PFS STILL not reached at 7 years, the longest ever in advanced NSCLC. 7-yr PFS 55% vs 3% for crizotinib. Clear 24 mo and you have a 79% chance of being PFS at yr 7. No new brain progression after 30 mo.
#LCSM @OncoAlert @OncBrothers @StephenVLiu @Jani_Chinmay @asco @myESMO @glopesmd @SylvesterCancer @latinamd @iaslc @COlazagasti
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Charles Swanton retweeted
We’re pleased to announce that @LeanneLi_Crick, from @TheCrick, will be speaking at the Cancer Grand Challenges Conference: Cancer and the host at The @royalsociety in London next month.
If you’re interested in hearing Leanne speak on the bidirectional interplay between the nervous system and cancer, joining other leading experts to discuss cancer as a systemic disease, view the full programme and secure your place 👇
cancergrandchallenges.org/co…
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Charles Swanton retweeted
May 7
Happy to share our new manuscript: Whole-genome doubling drives immune evasion by silencing antigen presentation: Cancer Cell cell.com/cancer-cell/fulltex… @LabPolyak @DFCI_BreastOnc @oesterreichs @Adrianvlee @ZheqiL
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Top #LungCancer Trials of April 2026, curated by @Larvol CLIN based on most viewed 𝕏 posts.
Explore more about oncology conferences, top trials, and reactions from oncologists: clin.larvol.com
#LARVOL #Oncology #CancerResearch #CancerData #OncologyInsights #ClinicalTrials #LCSM | @M_Torasawa | @StephenVLiu | @ADesaiMD | @CharlesSwanton | @HHorinouchi | @SonyaHessey | @OscarTahuahua | @BenCreelan | @FernandoOnco | @Latinamd
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Charles Swanton retweeted
May 3
How Does Lung Cancer Actually Spread? - Charles Swanton
@TheMarkFdn @CharlesSwanton
oncodaily.com/voices/charles…
#OncoDaily #Oncology #Cancer #Health #Medicine #MedX #MedTwitter
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Charles Swanton retweeted
Evolutionary characterization of lung cancer metastasis Nature (2026) nature.com/articles/s41586-0…
-28.4% of lung and 30.6% of intrathoracic lymph node metastases seeded other metastases, compared with only 8.3% of peritoneal and 10.7% of liver metastases.
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Charles Swanton retweeted
“In studies published in Nature, Aerts and colleagues found that people with a healthier thymus were less likely to develop lung cancer or to die of heart disease — or any cause. They also responded better to cancer immunotherapy treatments.” washingtonpost.com/health/20…
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Charles Swanton retweeted
A new Nature paper shows how lung cancer metastases evolve and spread through the body. The study used sophisticated genomic analysis to reconstruct how one metastasis can seed another, and how the pattern of spread is shaped by anatomy, tumor evolution, and cancer biology. The same probably can be said with breast cancer.
nature.com/articles/s41586-0…
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Charles Swanton retweeted
May 4
The insights into how lung cancer spread in our recent manuscript in @Nature would not be possible without the courageous & altruistic individuals who participate the #PEACE study, like Lydia: express.co.uk/life-style/hea…
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Charles Swanton retweeted
Apr 29
Another tour de force by an incredible team studying evolution of #lungcancer metastasis. Congrats to the investigators! @CharlesSwanton #TRACERx #PEACE
Apr 29
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Charles Swanton retweeted
Apr 30
“Tour de force”
Every medical oncologist and trainee should read it
Online here: nature.com/articles/s41586-0…
Open access here: rdcu.be/ff6YJ
Key supporters of this work are @CR_UK , @CRUKLungCentre , @UCLHresearch alongside many others
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