Medical Oncologist; clinical and translational researcher pancreatic and hepatobiliary cancers. Views are my own 🇮🇪🇨🇦

Joined August 2013
159 Photos and videos
Grainne O'Kane retweeted
Jun 10
#ILCA26 is supporting the next generation of liver cancer experts! We are offering free student registrations and travel grants for Brussels this September. Key details: ➡️Under 35 & an ILCA member ➡️First come, first served! ➡️Deadline: 29th June 2026 🔗ilcalive.org/annual-conferen…
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Grainne O'Kane retweeted
Jun 7
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Novel MEK1/2i (atebimetinib) GnP 1L #PDAC;single arm ph2 Drug anticachexia properties ➡️36% peritoneal met; 50%Liver ➡️n=55; ORR 42% 50pts median FU 10.4mths ➡️mPFS 8.3 mths,mOS 17.3mth ➡️manageable tox; combo strategies? ✅Ph3 MAPKeeper301 recruiting #ASCO26 @OncoAlert @ASCO
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SWOG S2001:maintenance olaparib/pembro v olaparib gBRCA1/2 #PDAC ➡️closed due to futility ➡️n = 73 mPFS 8.2 v6.4mths ➡️mOS 20 v 22.1mths Higher ORR but need understand TiME HRD-PDAC better for better combo! #ASCO26 @ASCO @OncoAlert @pancanireland @KReissMD
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Grainne O'Kane retweeted
Great discussion by @StephenLChan1 on new phase 3 studies of #immunotherapy combinations for #HCC at #ASCO26. How to combine in the intermediate stage and sequence in the advanced stage. @ASCO
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1st-line QLS31905 chemo in #PDAC & gastric ca -phase 1b/2 study. ➡️Claudin 18.2/CD3 Bispecific ➡️N=88 PDAC N=43 Gastric ca, ➡️82 PDAC pts mPFS 8.7 &mOS 15.9, ➡️43 GC pts mPFS 10.1 mths &mOS NR ✅tolerable & v promising activity! #ASCO26 @ASCO @OncoAlert
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Phase 3 IMbrave251:#ASCO26 Atezo/Len or Sora v Len/Sora 2nd line post atezo/bev ➡️Mostly Lenvatinib (92%) ➡️mOS 14.6 v 12.5; mPFS 4.3 v 4.8 ❎no role continue PD-L1i in 2nd line while switching to TKI➡️similar other ca  ✅new benchmark OS 2nd-line @ASCO @ILCAnews @OncoAlert
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EMERALD-3: STRIDE/Len/TACE v STRIDE TACE v TACE #HCC #ASCO26 N=760 , prim endpoint PFS arm A v C(multiple testing) ➡️ includes BCLC A/B/C ➡️mPFS arm A v C 13.0 v 9.8 mths ➡️mPFS arm B v C 12.9 v 8.1 mths ?OS benefit? 👇Mature data needed! @ASCO @OncoAlert
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Grainne O'Kane retweeted
Following the practice changing RASolute 302 pancreas discussion success @ASCO #ProfJenniferKnox with past Irish fellows & current fellow and colleagues from @pmcancercentre @PMResearch_UHN @RonanAndrewMcL1 @zaccoyne @graokane @EricaTsangMD @MCRCnews
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Adjuvant HAIP resectable #CRCLM with low CRS #ASCO26 ➡️n=110 resection pump v 108pts resection alone ❎no ⬆️in mPFS 15.0 v 16.0 mths ➡️hepatic PFS 37.6 v 21.8mths 90 day postop mortality 4pts v 1pt No role in this setting but feasible @ASCO @OncoAlert Imp study & 👏🏻presentation
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Special day #PDAC #ASCO26 ➡️RASolute302 plenary today &👇NEJM ➡️n=500, 2nd line Daraxonrasib v chemo ➡️mPFS RAS G12 7.3 v 3.5mth ➡️mOS 13.2 v 6.7mth(all) ➡️gd 3/4 AEs 61.8 v 69.6% ⭐️dawning new era⭐️ Congrats to authors! nejm.org/doi/full/10.1056/NE… @OncoAlert
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Not just one but two posters for the fabulous @orlaffitz 🇮🇪#ASCO26 🎉 ➡️genomic predictors outcome frontline BTC for chemo/IO-nb impact of KRASm! #BTC Also needs RAS strategies ➡️tracking genomic evolution HER2- altered #BTC - evolving field @CholangioIre @cancertrials_ie
Replying to @OrlaFitz10
@OrlaFitz10 Great work! Critical foundational work for our ongoing #R01. @GABOUALFA @EileenMOReilly @YJanjigianMD.
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ASCO/AACR joint session:KRAS journey drug dvpt-to beyond G12C ➡️combining G12Ci with IO in NSCLC Nb toxicity! ➡️incredible journey of pan-RASi-1st line already ➡️Allele specific &pan-RAS combos inc degraders& vaccines ➡️how can we optimise trial design! #ASCO26 @ASCO @OncoAlert
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Grainne O'Kane retweeted
A HUGE Round of thanks! The #OncoAlert5k 🚨Continues to Grow year after year, with a lot of new faces but also all the regulars🏃‍♂️ Thank you all of the great support! WE ARE INDEED ALL OncoAlert!! @Icro_Meattini @BalazsHalmosMD @alitimumab @MikeSerzanMD @barrosonco @DrVilmaPBarcia @DonjetaZeqa @crisonco @santcancela @golbretas @fedenichetti @crisonco @CathyEngMD @BenWestphalen @OncBrothers @graokane @realbowtiedoc @GaiaGriguolo @COR2EDMedEd @mirrorsmed @amerseburger @DrMirallas @ravikanesvaran @fabioturco92 @salvolarosa @KidneyCancer We Totally missed @to_be_elizabeth @ElisaAgostinett @nataliagandur and @CentralParkWMD @Latinamd @CathyEngMD @LaurenMachos @JooMouta2 @drteplinsky @matteolambe and many more but we look forward to seeing them at the 5k in Madrid🇪🇸 or during OUR HOMECOMING 5k in my HOME of San Antonio Tx🇺🇸for #SABCS26
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Early serial ctDNA dynamics resected stage I-IV CRC ➡️observational data GALAXY; tumor informed ➡️1915 pts ctDNA-ve at 4wks ✅persistent -ve:24mth DFS ~85% ➡️~3% ve (n=56) at 12wks -benefit chemo; more stg 4 ✅serial ctDNA early prognostic info #CRC #ASCO26 @ASCO @OncoAlert
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MCED testing in pop screening NHS-Galleri-RCT of 142,250 pts ➡️blood up to 3 visits ➡️aim to reduce stage III/IV Med FU 17mths ❎primary endpt not met-but ⬇️in stg4 ➡️52% PPV; 99.5% specificity ✅4 fold⬆️ in screen detected ca Huge effort from NHS #ASCO26 @ASCO @OncoAlert
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Grainne O'Kane retweeted
very fruitful discussion after super informative presentations! @EASLnews #HCC @NaultJc @EASLedu @SherrieBhoori @graokane @BCLC_group
Replying to @EASLnews
@EASLnews session devoted to systemic therapy for liver cancer ready to begin. @ma5RN displaying the BCLC expertise and vision within a panel of friends and also experts @hospitalclinic @idibaps @ContraCancerEs
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Grainne O'Kane retweeted
The OncoAlert🚨 GI faculty’s TOP 10 abstracts In GI Oncology for #ASCO26 are here — selected by our leads and finalized through a Delphi voting process with our senior experts across #ColorectalCancer #ColonCancer #LiverCancer #PancreaticCancer and more A snapshot of what will shape GI oncology at #ASCO26 👇 🚨 OncoAlert Top 10 — #GIcancer at #ASCO26 1️⃣ LBA5 | RASOLUTE 302 — Daraxonrasib vs chemo in previously treated metastatic pancreatic adenocarcinoma 2️⃣ #4017 | FIGHT-302 — Pemigatinib in untreated unresectable/metastatic FGFR2-rearranged cholangiocarcinoma (Ph3) 3️⃣ LBA4000 | EMERALD-3 — Tremelimumab durvalumab lenvatinib TACE in unresectable HCC (Ph3) 4️⃣ #3506 | PUMP Trial — Adjuvant HAIP floxuridine in resectable colorectal liver metastases 5️⃣ LBA3500 | CIRCULATE — ctDNA-guided adjuvant therapy in Stage II colon cancer 6️⃣ LBA3503 | BREAKWATER — Encorafenib cetuximab FOLFIRI as 1L in BRAF V600E mCRC (Ph3) 7️⃣ LBA3508 | EPISODE-III — Adjuvant aspirin vs placebo in Stage III CRC post-resection (Ph3) 8️⃣ #3505 — Trastuzumab rezetecan vs SOC in chemo-refractory HER2 advanced CRC (Ph3) 9️⃣ #4006 | ATTRACTION-6 — Nivo ipi chemo as 1L in HER2− advanced gastric/GEJ cancer 🔟 #3504 | SWOG S2107 — Encorafenib cetuximab nivo in MSS BRAF V600E mCRC (Ph2) Leads @realbowtiedoc @p_ciracimd @WeOncologists Senior faculty @CathyEngMD @ARosen380 @GillSharlene @BenWestphalen @graokane Participating AF @DrVilmaPBarcia @Erman_Akkus @GIMedOnc
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Grainne O'Kane retweeted
The International Liver Cancer Association (ILCA) Annual Conference is Sept. 3–5 in Brussels, gathering global experts advancing research, diagnosis, and management of liver cancer. Register using code ILCAAC26_CCF for 15% off: ilcalive.org/annual-conferen…
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