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🧠 New Research on #Nrsn2 #Knockout & Brain Connectivity in #NeurodevelopmentalDisorders 🐭🔬✨ Ultra-high-field 11.7T MRI reveals that loss of Neurensin-2 alters functional brain networks without changing brain structure! 🎯🧩 Key Insights: ✅ #Nrsn2 is a neuro-specific gene linked to autism, Alzheimer's, and 20p13 microdeletion syndrome 🧬 ✅ #CRISPR_Cas9 generated Nrsn2-/- mice – mRNA of exon 3 reduced by nearly 100% ✂️ ✅ No significant changes in gray/white matter volume or regional activity (VBM, ALFF, DTI) 📉 ✅ Major alterations in functional connectivity within sensory systems (gustatory in juveniles, auditory in adults) 🔊👅 ✅ Adult Nrsn2-/- mice show reduced connectivity in #DefaultModeNetwork regions – possible link to stress resilience 🧘‍♂️ 📚Published by: Yuan Yi, Fei Dai, Yuwen Zhang, Jiawei Han, Jialu Wei, Lingbo Wang, He Wang, Yu An 📅 Published in: 2024 📄 Full Study: doi.org/10.1007/s43657-024-0… #MRI #FunctionalConnectivity #Neurogenetics #SensoryProcessing #Depression #GeneEditing #TranslationalNeuroscience 🚀
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연구자들이 사람들의 뇌에 전극을 직접 삽입해 조사한 결과, 창의적 사고를 담당하는 뇌 네트워크가 집중된 작업이나 콘텐츠 소비 중에는 완전히 꺼져버리는 것을 발견했습니다. 이 네트워크는 오직 아무것도 하지 않을 때('do nothing')에만 활성화됩니다. 🔬 더 정확히 말하면: DMN(Default Mode Network)은 “완전 휴식”뿐 아니라, **먼저 미친 듯이 고민(준비 단계)** 한 후에 산책·놀이·샤워 같은 순간에 진짜 폭발합니다. Elon Musk가 말하는 “샤워할 때 아이디어가 번뜩인다”는 바로 이 메커니즘! 화면 내려놓기 사전 분투 노력 = 창의력 풀충전 🔥 #DefaultModeNetwork #창의성과학
Researchers put electrodes in people’s brains and found the network responsible for creative thinking shuts off completely during focused tasks and content consumption. It only fires when you do nothing. Your best ideas are behind the screen you won’t put down.
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More precisely: The DMN is suppressed during intense focus and scrolling — that part is spot on. But it’s not *only* when you “do nothing.” True creativity kicks in when you first go all-in on the problem (Elon-style deep struggle), then let incubation happen during walks, hobbies, or showers. Preparation Downtime = the real “aha” moments 🔥 #DefaultModeNetwork #CreativityScience
Researchers put electrodes in people’s brains and found the network responsible for creative thinking shuts off completely during focused tasks and content consumption. It only fires when you do nothing. Your best ideas are behind the screen you won’t put down.
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Many people report “otherworldly” experiences during deep chanting or immersive music sessions — sensations of bliss, silence, lightness, emotional release, or tingling in the head. While these states feel mystical, neuroscience offers insight into what may be happening. Slow, repetitive sound patterns can reduce activity in the Default Mode Network — the brain region associated with ego, rumination, and constant self-referencing. At the same time, rhythmic sound waves can increase neural synchronization and alter sensory processing. This shift often corresponds to deeper nervous system regulation, extended exhalation patterns, and reduced cognitive overload. In other words, what feels transcendent may also be a measurable neurological state. Sound is not only emotional — it is structural. It reorganizes rhythm in the brain. And when brain rhythm changes, perception changes. #soundhealing #neuroscienceofmusic #defaultmodenetwork #brainwaves #chantingmeditation #musictherapy #nervoussystemhealth #brainregulation
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Caminado con mi husky pensaba en comprar audiolibros para aprovechar este tiempo, pero este video me abrió los ojos. 🤯 El cerebro necesita aburrirse para ser creativo (activa la #DefaultModeNetwork). ¡Adiós audiolibros, hola DMN! 🚶‍♀️🧠 Véanlo: youtu.be/Z60IsB2awms
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#Boredom, Managing our Internal Experience and Underlying Important Internal Cognitive Experiences: What Your #Brain Is Doing When #DoingNothing; The highlighted brain regions, a collection of seemingly unrelated areas shown here: - dorsal and ventral-#MedialPrefrontalCortices - #PosteriorCingulateCortex - #Precuneus - #AngularGyrus, become more active when we’re doing nothing, in managing our #InternalExperience. This “#DefaultModeNetwork” is associated with #InternalCognitiveExperiences including: - #Memory, - #ExperienceReplay, - #ActionConsideration - #Prediction - #Reward/#Punishment - #InformationIntegration quantamagazine.org/what-your… via @QuantaMagazine
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#BrainImaging Series-9 🧠 How does consciousness connect to the brain’s default mode network? New study reveals strong correlations between CRS-R scores and neural integrity in the mPFC–PCun/PCC pathways in TBI patients with disorders of consciousness. 🔍 DTT shows mPFC–PCun network plays a key role. 🔗 Read more: doi.org/10.31083/j.jin220203… Explore the full collection: 1️⃣ Relationship between the Consciousness State and the Default Mode Network in Traumatic Brain Injury: doi.org/10.31083/j.jin220203… 2️⃣ Effects of the Left M1 iTBS on Brain Semantic Network Plasticity in Patients with Post-Stroke Aphasia: A Preliminary Study: doi.org/10.31083/j.jin220102… 3️⃣ Altered Effective Connectivity of the Pain Matrix in Herpes Zoster and Postherpetic Neuralgia Patients: Granger Causality Analysis of Resting-State fMRI: doi.org/10.31083/j.jin230814… 4️⃣ Association between Enhanced Effective Connectivity from the Cuneus to the Middle Frontal Gyrus and Impaired Alertness after Total Sleep Deprivation: doi.org/10.31083/j.jin230917… #BrainImaging #Neuroimaging #TBI #Consciousness #DefaultModeNetwork #DTI #DTT #CRSR #mPFC #PosteriorCingulate #TraumaticBrainInjury #Neurology #FunctionalConnectivity #JINjournal #BrainHealth
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#Boredom Is Good for You: Why Embracing It Calms the Brain Boredom, often seen as a negative state to avoid, may actually serve an important role in #EmotionalRegulation & #BrainHealth. When we’re bored, the brain shifts away from #ExternalAttentionNetworks & activates #IntrospectiveSystems like the #DefaultModeNetwork; Short-#IntentionalPauses from #Stimulation may foster #Creativity, strengthen #EmotionalResilience, Reduce #Anxiety/Dependence-on-#ExternalGratification. neurosciencenews.com/boredom… via @neurosciencenew
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I very much enjoyed meeting with Chris Ching and members of his @PTenigma lab team at @USC. I now understand the secret behind the great success of their work: With such a workplace environment (their offices are just a stone's throw away), one's #DefaultModeNetwork sure is in good shape😉. Looking forward to joint projects on #Lithium response in #BipolarDisorder! Thanks for an inspiring Southern California morning, folks!
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Your self-esteem isn’t shaped by others’ words or actions but by how you let them influence your beliefs. #psychology #selfesteem #defaultmodenetwork #selfappraisalsystem #social #virtue #virtuesignaling
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📢New Open🔓 Access Article Alert Compensation versus deterioration across functional networks in amnestic mild cognitive impairment subtypes by Benxamín Varela-López (@BenxaminL) & Santiago Galdo-Alvarez et al. rdcu.be/dXvip #restingstatefunctionalmagneticresonanceimaging #amnesticmci #defaultmodenetwork #frontoparietalcontrolnetwork #cognitiveimpairment
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#BCMNeurosurgery's Drs. Eleonora Bartoli, @KBijanki, @SameerShethMD and @AdrishAnand, in collaboration with a team from @UofUNeurosurg, seek to explain the role the #brain's #DefaultModeNetwork (DMN) plays in #creativethinking 🧠 Read more in @PsyPost: tinyurl.com/4ybejwdt
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Wo sitzt die Kreativität in unserem Gehirn? Hirnwellen enthüllen neuronale Schaltstelle des kreativen Denkens scinexx.de/news/psychologie/… #Wissen #Neurowissenschaft #Gehirn #Kreativität #Ruhezustand #Tagtraum #DefaultModeNetwork

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Creativity’s Neural Origin Revealed Researchers have identified how the brain’s #DefaultModeNetwork (#DMN) collaborates with other regions to produce #CreativeThought. By using advanced brain imaging techniques, they tracked real-time brain activity during creative tasks. This study reveals that : -the DMN initiates creative ideas, -which are then evaluated by other brain regions. Understanding this process could lead to interventions that enhance #Creativity and aid #MentalHealth treatments. neurosciencenews.com/creativ… via @neurosciencenew
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