Uncovering How HCoV-229E Hijacks Host RNA-Processing Complexes Find More Research: pubmed.ai/?utm_source=X&utm_… A growing body of structural-proteomic evidence shows that HCoV-229E replication depends on its ability to remodel host RNA-processing complexes. The infection induces significant conformational rearrangements within key RNA-modifying assemblies, effectively redirecting host machinery to favor viral RNA synthesis. From a mechanistic standpoint, this raises important questions for the field: – Why are specific RNA-processing complexes uniquely vulnerable to viral remodeling? – Are these conformational shifts conserved across other human coronaviruses? – Could small molecules or peptides be engineered to “lock” these complexes in antiviral states? The work highlights a broader theme in viral pathogenesis: structural hijacking, not just transcriptional interference, is central to replication success. Targeting these dynamic complexes may offer a new therapeutic paradigm beyond traditional polymerase or protease inhibitors. #StructuralVirology #RNAProcessing #CoronavirusResearch #MolecularMechanisms #HostPathogenInteraction #AntiviralStrategy

How HCoV-229E Rewires Host RNA-Processing Machinery to Sustain Viral Replication Find More Research: pubmed.ai/?utm_source=X&utm_… Human coronavirus-229E (HCoV-229E) provides a striking example of how viruses exploit host-cell infrastructure with remarkable precision. Recent work using limited proteolysis–based mass spectrometry shows that infection triggers major conformational shifts in host RNA-processing complexes—changes that directly support viral genome replication and transcription. What makes this discovery compelling is its translational potential: 🔹 RNA-processing assemblies emerge as druggable structural nodes 🔹 Structural modulation—not just gene expression—becomes a therapeutic frontier 🔹 Mechanistic insights appear conserved across multiple coronaviruses, opening broader antiviral avenues As the field moves toward structure-aware antiviral design, understanding how pathogens manipulate dynamic host machinery will be central to forecasting the next generation of therapeutics. #Virology #Coronavirus #RNAProcessing #StructuralBiology #MassSpectrometry #AntiviralTargets #FutureOfMedicine

Ready to test your virology instincts? 🧬 Dig into the science, try the quiz, and explore the original papers faster with PubMed.ai — your smarter way to search biomedical literature. 🚀🔍 Which new technology now allows researchers to capture increasingly precise snapshots of host–virus interactions? 🤔 Just dropped a new deep-dive on how HCoV-229E hijacks human RNA-processing machinery — and why even “mild” coronaviruses matter for future pandemic preparedness. Find the answer here: medium.com/@harryblackwood/h… #Virology #Coronavirus #229E #RNAprocessing #MedicalResearch #PubMedAI

RESEARCH PAPER: A kinetic ruler controls mRNA poly(A) tail length By Gabs et al. and Matti Turtola ➡️ genesdev.cshlp.org/content/3… #RNAprocessing #mRNA #polyadenylation #ribonucleoprotein #CPAC

🔬 Breaking: Reduced intronic polyadenylation in #GLS triggers #CellularSenescence via mitochondrial dysfunction (↑#ROS ↓#ATP). Key finding: #CPSF6 regulates this #RNAProcessing pathway! #Mitochondria #GeneRegulation #Phenomics Full text link:🔗 link.springer.com/article/10…

"Single-molecule multimodal timing of in vivo mRNA synthesis" a collaboration with Rippei Hayashi's lab, work led by AJ Sethi @_AJSethi #RNA #premRNA #splicing #RNAprocessing #m6A #polyadenylation biorxiv.org/content/10.1101/…

Spliceosomes use quality control mechanisms to detect and correct mistakes during RNA processing. Our work explores how defective spliceosomes are identified and discarded. #RNA #RNAProcessing #Spliceosomes #QualityControlMechanisms #RMAP nature.com/articles/s41594-0…

What a day! The @FMIscience hosted the TriRhena Next Gene Regulation Club! More than 100 scientists from the TriRhena region gathered to discuss exciting topics in gene regulation, including #chromatin, #transcription, and #RNAprocessing. #ScienceCollaboration

What an amazing opportunity was to attend @ItsRMaP1 meeting on #RNAprocessing and #RNAmodifications in @imbmainz last week 🙌 exciting science and discussions 🚀🚀 glad to have met in person @koenig_lab ✨ special thanks to @cereda_lab @psychonaut 🌟

Kudos ✨ to @mchiaragrieco presenting today our ongoing work on the interplay between #genomicinstability and #RNAprocessing in #cancer at the progress report in @fpoirccs and @IIGMufficiale 🚀🔥🙌

Don`t forget to register for the 5th @NCCR_RNADisease #SummerSchool in the #SwissAlps.🏔️ ➡️Registration deadline: April 26th⬅️ #RNAModifications #Translation #Compartmentalisation #Development #RNAProcessing #RNALocalisation

Nuclear localization of #TDP43 is crucial for its function during #RNAprocessing & #neurodegeneration. @AyalaLab1 &co show that #RNAbinding & macromolecular assembly, including via #LLPS, play a central role in TDP-43 nuclear retention #PLOSBiology plos.io/3v372fT

Nuclear localization of #TDP43 is crucial for its function during #RNAprocessing & #neurodegeneration. @AyalaLab1 &co show that #RNAbinding & macromolecular assembly, including via #LLPS, play a central role in TDP-43 nuclear retention #PLOSBiology plos.io/3v372fT

Nuclear localization of #TDP43 is crucial for its function during #RNAprocessing & #neurodegeneration. @AyalaLab1 &co show that #RNAbinding & macromolecular assembly, including via #LLPS, play a central role in TDP-43 nuclear retention #PLOSBiology plos.io/3v372fT

Nice #Review ! #RNAProcessing #GenomeOrganization #GenomeStability #RNA #Genome #DIS3 #MultipleMyeloma #Bcell #RNAExosome

HIRN Webinar: RNA Processing in Metabolic Tissues Presentations by: Drs. Lori Sussel & Rohit Kulkarni Wed July 12 at 1pm EDT/10am PDT (1-hour) Register at: tinyurl.com/HIRN-July-2023 All Welcome! Please share/retweet! #RNA #RNAprocessing #tissues #data #T1D #diabetes

📢New issue celebrating work from the FEBS fellows! 🌟Review articles & Research Protocols authored by Long-Term Fellowships programme representatives 🔗buff.ly/3JM2D5b #PlantSci #RNAprocessing #Metabolism #ProteinDegradation #StructuralBiology #Immunology #Circadian

Check out this Hypothesis article in our June issue from authors at @amsterdamumc! Systematic analysis of splicing networks in the heart reveals common targets and pathways among splicing factors buff.ly/41zbHRQ #cardiomyocytes #RNAprocessing #CardioTwitter

Online today! 👉Multi-omic profiling reveals an #RNAprocessing rheostat that predisposes to #prostatecancer By M. Stentenbach, A. Filipovska & colleagues @FilipovskaLab @PerkinsComms 🗞️Read #openaccess: doi.org/10.15252/emmm.202317…

Congratulations, Dr. Maria Sterrett! 😊🎓🎉🍾@MariaCSterrett Wonderful Ph.D. Defense! Pleasure to have followed your scientific journey in the last few years and worked together on the #RNAExosome (Pacman) and #RNAProcessing in #BuddingYeast