Noha El anwar retweeted
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Happy to share our new #PediPath contribution on diagnosing #Ovotestis #Uropath #DSD @clamsalgado @UMiamiPathology link.springer.com/article/10…
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🔎 Histo-cyto correlation!
👉 74-year-old female with hematuria and bladder mass
⚓️ Urine cytology showed features suspicious for High-Grade Urothelial Carcinoma (HGUC) with:
🔬 Hyperchromatic crowded cell clusters
🔬 Single scattered atypical cells
🔬 Marked pleomorphism, high N:C ratio
🔬 Irregular nuclear membranes & coarse chromatin
💎 Biopsy confirmed High-Grade Papillary Urothelial Carcinoma showing fused/complex papillae, loss of maturation, diffuse cytologic atypia, and numerous mitoses.
A nice histocytologic correlation case highlighting the importance of urine cytology in detecting HGUC.
#PathTwitter #Cytopathology #Uropath #Surgpath #UrineCytology #HGUC #UrothelialCarcinoma #Histopathology #MedEd #Pathology
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A nodule on the face. Sent as a skin biopsy. No clinical history provided. Spoiler: this is NOT a primary skin tumor. 👇
#pathtwitter #dermpath #uropath #pathology
ALT H&E staining. Skin biopsy: intact epidermis and a dermal tumor composed of clear cells, separated by a prominent network of thin-walled vessels.
ALT H&E staining. Skin biopsy: intact epidermis and a dermal tumor composed of clear cells, separated by a prominent network of thin-walled vessels.
ALT H&E stain. High-power view showing tumor cells with abundant clear cytoplasm and small, round, uniform nuclei. Thin-walled vessels are visible between tumor cell nests.
ALT H&E stain. High-power view showing tumor cells with abundant clear cytoplasm and small, round, uniform nuclei. Thin-walled vessels are visible between tumor cell nests.
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💫🌟 Redefining GU cancer precursors
@EUplatinum @OncoAlert
🌍 ISUP Consensus (Florence) sets a NEW framework for GU premalignant lesions:
🔵 Prostate: IDC → must report (aggressive biology)
🟡 Bladder: CIS remains key precursor
🟠 Kidney: Papillary adenoma = only established precursor
🟢 Testis: GCNIS → definitive precursor
🔴 Penis: PeIN unified classification
📌 Standardization = better diagnosis & clinical decision-making
🔗 europeanurology.com/article/…
🔗 authors.elsevier.com/a/1mtG5…
@ecancer @urotoday @MedicalwatchHQ
@ASCOPres @DrYukselUrun @montypal
@PGrivasMDPhD @tompowles1 @shilpaonc
@neerajaiims @UroDocAsh @TiansterZhang
@gbanna74 @katy_beckermann
@DrKarineTawagi
#GUOncology #UroPath #PrecisionMedicine #ProstateCancer #BladderCancer #OncoTwitter
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Malakoplakia of bladder: Sheets of histiocytes (von Hansemann cells) packed with granular cytoplasm and the pathognomonic Michaelis–Gutmann bodies—round, targetoid inclusions reflecting defective phagolysosomal activity and chronic E. coli infection.
#Pathology #UroPath #MedEd
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Happening this Wednesday! From morphology and basics to molecular advancements and more- This @GU_Path_Society webinar is a Do Not Miss!! #GUPath #PathResidents #UroPath
In case you haven't registered for the 1st GUPS/IAP (Arab Division) Joint Educational Series Webinar on Feb 4th, here are some reasons to do so right away!
🔸Practical topics relevant to daily sign outs
🔸Renowned expert speakers
🔸FREE registration: tinyurl.com/2smm5vnw
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In prostate adenocarcinoma...does anyone know what those basophilic cytoplasm cells are? Do you suggest any IHC? #pathology #pathologic #uropath #uropathology #prostate @SEAP_IAP @IntSocUropath @AbhijitSurgPath @
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Jan 18
1/ Dear #GUPath #Uropath
A 56-year-old male patient presents with a well-defined, oval renal nodule of homogeneous density, measuring up to 3 cm in diameter. Microscopically, multiple core biopsies cylinders are composed of epithelial neoplasm displaying both papillary and tubular structures, lined by cuboidal to columnar epithelium with variable cytoplasm, from clear and finely vacuolated to pale eosinophilic. The nuclei show slight size variability mostly in basal position without prominent nucleoli or significant mitotic activity, . The stroma is sparse and hyaline, with numerous aggregates of foamy macrophages, no pasamommas identified .
In view of the emerging spectrum of renal papillary entities, and that papillary renal carcinoma is known for being able to present clear cells, which can be a pitfall.
I would appreciate the opinion for this tumor, which I favor to be a papillary renal cell carcinoma.
What is your diagnoses ,would you sign out without IHC?
? What is your suggested immunohistochemistry.
🙂🙏,poll at the end of thread
@slusagar
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🌟🚨 New insights into a rare bladder cancer subtype🌟
Study in AJCP characterizes urothelial carcinoma with osteoclast-like giant cells (UCOGC), a poorly understood and exceptionally uncommon variant of #BladderCancer.
Key findings:
🔹 Distinct biphasic morphology (mononuclear cells osteoclast-like giant cells)
🔹 Unique immunophenotype: high CD68, CD163, SATB2, cathepsin K
🔹 GCs lack urothelial markers, supporting true osteoclast-like phenotype
🔹 NGS mutations align with conventional urothelial carcinoma
🔹 Evidence supports UCOGC as a unique, distinct subtype, not just “poorly differentiated UC”
💡 Takeaway: Improved recognition of UCOGC may refine diagnosis, prognostication, and future therapeutic strategies for this rare and aggressive entity.
📄 Rizkalla C.N., Tretiakova M., Suarez C.J., Williamson S.R., Al-Obaidy K.I., Acosta A.M., Idrees M.T., Chan E., Potterveld S., Sangoi A.R.
🔗 doi.org/10.1093/ajcp/aqaf044
@OncoAlert 🚨
#PathTwitter #UroPath #GUPath #BladderCancer #RareTumors
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