What Does Single-Cell RNA Sequencing Tell Us? Single-cell RNA sequencing offers a detailed snapshot of what each cell is doing at a given moment, revealing its genetic activity and potential protein functions. By analyzing transcriptomic data, researchers can predict how individual cells contribute to brain function and disease, even when RNA-protein correlations aren’t perfect. 🎥 Watch Episode #27 with Dr. Verena Haage to explore how #SingleCellRNASequencing, #Microglia, and #Transcriptomics are transforming our understanding of #brain health, #aging, and #disease. Neuroscience and Beyond: Episode Highlights We hosted Dr. Verena Haage, guest scientist at @ChariteBerlin and co-founder of @Sci_Lead, to discuss how cutting-edge tools like single-cell RNA sequencing are reshaping microglia research. She explained how these immune-like brain cells influence development, aging, and neurodegeneration, and highlighted the importance of linking molecular data with the exposome for a deeper understanding of brain health. #Neuroscience #BrainHealth #Neuroimmunology #Proteomics #Neurodegeneration #SciLead #WomenInScience Watch the full episode on this link: youtu.be/ZRQzm6BKyqo?si=nwD3… Find us on social media: linktr.ee/neurosciencebeyond

At Med #GrandRounds today @nyugrossman, Aristotelis Tsirigos, PhD (@artsinyc) gave an outstanding talk on how single-cell RNA sequencing can be leveraged to map tumor heterogeneity and guide therapeutic strategies in the future. Key Takeaways: ▶️ Single-cell RNA-seq in PDAC samples revealed extensive heterogeneity in the tumor epithelial compartment ▶️ This heterogeneity is linked to the presence of multiple major genetic clones ▶️ Each clone activates specific oncogenic pathways ▶️ Clones form their own distinct clone microenvironment in the vast majority of tumors ▶️ Tumor clones are highly dynamic and undergo continuous evolution ▶️ This makes PDAC tumors particularly challenging to treat #MedTwitter #PublicHealth #MedEd #MedResearch #PrecisionMedicine #PrecisionOncology #CancerResearch #SingleCellRNASequencing #Heterogeneity

Check eCM paper: Who drives the progress of osteoarthritis? – A descriptive study of synovium-meniscus crosstalk F Yu, TT Qi, J Weng, TB Wang, P Liu, YQ Chen, A Xiong, DL Wang, H Zeng #Osteoarthritis #synovium #meniscus #singlecellRNAsequencing ecmjournal.org/papers/vol048…

We are having a wonderful time in #Erlangen for #ICVPB! Fantastic presentations from Dr. @thibeaultlab , Vlasta Lungova, @AlexGavinFoote and @AnumithaVenkat1 ! #tissueengineering #singlecellRNAsequencing #microbiology #larynx #voicescience @WiscSurgery @WiscOtoHNS @NIDCD

Assoc. Prof. Iwata and colleagues have uncovered a novel mechanism of #ILC2development, using #singlecellRNAsequencing, which could lead to new treatment strategies for #allergicdiseases. cn.chiba-u.jp/en/news/press-… #Immuneregulation #lymphocyte #asthma #genetherapy @NatureComms

#NewNProt for #singlecellRNAsequencing and #functionalgenomics of murine #eosinophils bit.ly/4avUIEi @moorlab @lab_arnold

☕️NEW: @YoshiakiKubota, Takubo & co perform #SingleCellRNASequencing and identify a #BoneMarrow #EndothelialCell subtype that contributes to the acquisition of bone strength and offers a distinct #HematopoieticStemCell niche. @Keio_univ_PR nature.com/articles/s41556-0…

Learn how #SingleCellRNASequencing is used to develop novel treatments for conditions like dry skin, Alzheimer's, and cancer from #JournalOfPharmaceuticalAnalysis articles. Read more: prnewswire.com/news-releases…

Research featured in the #JournalOfPharmaceuticalAnalysisemploys #SingleCellRNASequencing to uncover causes of #DrySkin and Alzheimer’s, as well as the #AntiTumor effects of cannabidiol. Read more: eurekalert.org/news-releases…

Giacomo and @GiuliaCesaro4 are expanding their knowledge of #networkscience at the Mediterranean School of Complex Networks #MSCX in Catania, while also unveiling its potential in the fields of #singlecellRNAsequencing and #microbial interaction #networks. ☀️🔬

A tissue-resident #monocytic cell is discovered in #arthritis patients' synovium through #singlecellRNAsequencing Learn more here: cell.com/cell-reports/fullte… #phenomics @CellReports

🔓#SuggestedRead 📖Stiffness is associated with hepatic stellate cell heterogeneity during liver fibrosis by Vijay H. Shah et al. 🖱ow.ly/5zvE50Nbmop @EKostallari_PhD @dtschump1 #fibrosis #MagneticResonanceElastography #AtomicForceMicroscopy #SingleCellRNAsequencing

In de week dat ik langzaam weer mijn normale leven oppak na mijn operatie (#TLH), komt dit mooie onderzoek naar buiten in @NatureGenet: Cel-atlas is begin van betere aanpak endometriose nrc.nl/nieuws/2023/01/11/cel… #endometriose #SingleCellRNASequencing

Join us on 12th January at the Molecular & Clinical Cancer Medicine seminar series where @livuniISMIB's Dr @AinhoaMielgo outlines how her team use #flowcytometry, #spatialtranscriptomics, #singlecellRNAsequencing and other technologies to explore #metastasis in #pancreaticcancer

I wish you all a happy 2023!! With a lot of successful single-cell experiments! 😉 #singlecell #singlecelltranscriptomics #singlecellrnasequencing #singlecelltechnology

📢New in GeroScience Rapid emergence of #transcriptionalheterogeneity upon #molecularstress predisposes cells to two distinct states of #senescence by Nikolay Burnaevskiy, Junko Oshima & Alexander R. Mendenhall. link.springer.com/article/10… @UW #singlecellrnasequencing #aging

Happy RNA Day! Contact us to find out #RNAday special offer! 😊 RNA-related services here: bit.ly/3Q5ortm RNA-related webinar here: bit.ly/3PO8gkk #NGS #singlecellRNAsequencing #mRNAsequencing #ncRNAsequencing

📢Recommended Reading📖on the effect of #aging on #senescence in various #Braincell types measured by #singlecellrnasequencing.⬇ link.springer.com/article/10… @OUResearch @Uni_Szeged @semmelweishu @OMRF

Methods: To look at the impact of this variant on the developing brain, we differentiated patient and control induced pluripotent #stemcells to cerebral #organoids and then did #singlecellRNAsequencing. This allowed us to look at disease mechanisms in distinct neural cell types.

#SinglecellRNAsequencing, which facilitates the analyses of hundreds of #cells and ten thousands of #genes at once, has uncovered new mechanisms of #heartdisease and potential new therapeutic venues bit.ly/3w58jRA #scRNAseq #hypertrophiccardiomyopathy