Geneticist and research scientist at Mayo Clinic working to better understand, diagnose and treat B-cell malignancies. Opinions on Twitter are my own.

Joined April 2009
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An incredible experience. 30 miles of hiking with new friends. The best part: the team raised $75K for MM research! So grateful for the opportunity @GD_251
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Great seeing all of you!
Myeloma team at hematologicalmalignancies health and disparities meeting Great programme
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Super cool study. A good reason not to fast.
Dearest gentle reader, we are delighted to announce a new story from our lab published in @Nature describing how a meal's systemic metabolic changes are interpreted by your immune system to enhance adaptive immunity. A thread 1/ nature.com/articles/s41586-0…
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Thrilled about this collaborative project evaluating venetoclax response in the myeloma subtype I’m so curious about-t(11;14). Grateful to all of the collaborators included here.
Excited to share our first 2026 paper from the lab! In a collaboration with @MayoClinic @MSKCancerCenter @EmoryUniversity @SylvesterCancer @OsuChsd & @MSK_DeptOfMed, we investigated the drivers of venetoclax resistance in t(11;14) Multiple Myeloma #mmsm. ashpublications.org/blood/ar…
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Standardizing FISH testing in myeloma is critical to reduce lab to lab variability and misinterpretation. We propose guidelines for FISH panel design and reporting to align with the new IMS/IMWG risk stratification. @CG_Consortium @MayoMyeloma
Just out: Guidelines for testing and reporting cytogenetic results in myeloma @BloodCancerJnl#OpenAccess Bookmark! Allows you to incorporate latest IMS/IMWG high risk criteria in practice. ⁦@lbaughn⁩ ⁦@RahulBanerjeeMD⁩ ⁦@Rfonsi1nature.com/articles/s41408-0…
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Linda B. Baughn retweeted
We will also be providing recommendations to other labs on how to perform and interpret to meet the IMS/IMWG definition with a publication led by @lbaughn in @BloodCancerJnl shortly. Stay tuned.
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Linda B. Baughn retweeted
Visualize genomic data with ease using gggenomes, an R package that extends ggplot2 to handle and display genomic information intuitively. Whether you’re comparing genomes, analyzing features, or showcasing synteny, gggenomes provides the tools you need to turn complex genomic data into clear, informative visualizations. Why use gggenomes? ✔️ Genomic-focused visualizations: Specifically designed for handling genomic data, including features, alignments, and comparative analysis. ✔️ Versatile and modular: Create detailed and layered plots for diverse genomic scenarios with flexibility for customization. ✔️ Built on ggplot2: Leverages ggplot2’s familiar framework, making it easy for users to adapt and enhance their visualizations. The example visualization shown here is taken directly from the gggenomes GitHub repository, demonstrating how it transforms genomic data into compelling plots: github.com/thackl/gggenomes Curious to learn more about creating data visualizations in R and using tools like ggplot2 and its extensions? Check out my online course, "Data Visualization in R Using ggplot2 & Friends!" Take a look here for more details: statisticsglobe.com/online-c… #datascienceeducation #Statistical #datastructure #RStats
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FISH testing for MYC is part of routine clinical evaluation for high grade B-cell lymphomas. We showed a high false negative rate for the MYC break apart FISH probe (4%) or the MYC/IGH probe (22%). Thus, FISH will not detect all MYC rearrangements in B-cell lymphomas.
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We propose interpreting unbalanced MYC-r by FISH in HGBCL as “likely positive”. I hope future testing will incorporate WGS and/or RNA seq.
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A recently published paper supports the reporting of these unbalanced MYC-R as positive. Nice to see additional support for unbalanced MYC-R as being real abnormalities sciencedirect.com/science/ar…

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Linda B. Baughn retweeted
The MMRF Immune Atlas team describes immune cells & clinical outcomes in myeloma. Emory, Beth Israel, WUSTL, MSSM, Mayo & MMRF profiled >1.1 million marrow cells from CoMMpass patients. Preprint at biorxiv.org/content/10.1101/… has details. #myeloma
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We are eager to hear from the community clinicians!
We have to reach physicians in the community to see how we can get their input. Can @ACCCBuzz help to get this survey out and partnering with them. Apart from risk stratification, can we report that BCL2 inhibitors can be used in the FISH report. @PedalheadPHX @lbaughn
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Thank you to those who have completed the myeloma FISH survey! We are so grateful. If you haven’t yet completed the survey, we ask you to please consider making your voice heard. Your responses are so valuable. #MMSM @RahulBanerjeeMD
Our goal is to improve FISH reporting for myeloma. If you are a myeloma clinician, please consider this survey. Your responses will be helpful as we propose solutions for standardization and improve reporting clarity. Thank you! @MayoMyeloma
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Linda B. Baughn retweeted
Grand challenge of moving cancer whole-genome sequencing into the clinic. Comment on the largest whole-genome sequencing study- a myriad of actionable alterations and logistical,technical and economic challenges #precisionmedicine @NatureMedicine bit.ly/3NY4yWo

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Linda B. Baughn retweeted
Excited to see our new paper entitled "Genomic Classification and Individualized Prognosis in Multiple Myeloma" out on @JCO_ASCO! A fantastic collaboration between @SylvesterCancer, @univmiami, @MSKCancerCenter, @nyulangone, @MoffittNews, @HDMyeloma and many others!! #mmsm (1/x)
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Our goal is to improve FISH reporting for myeloma. If you are a myeloma clinician, please consider this survey. Your responses will be helpful as we propose solutions for standardization and improve reporting clarity. Thank you! @MayoMyeloma
Are you a myeloma clinician who orders FISH tests? If so, the CGC Plasma Cell Neoplasm Working Group is interested in your feedback! FISH reports can be confusing and we want to learn about your experiences to help optimize cytogenetic reports. Survey: surveymonkey.com/r/VKTFVTS
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Linda B. Baughn retweeted
single-cell folks, what's the cell annotation tool do you recommend for immune cells and tumor cells? singleR? Seurat based label transfer? or sc-best-practices.org/cellul… I still find myself using marker genes manually quite often

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A great opportunity at University of Minnesota
We have just launched a new faculty recruitment in bacteriology at the University of Minnesota. Check it out! Assistant or Associate Professor - Bacteriology jobs.sciencecareers.org/job/…
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