@moitrayee_lab profile picture
Bhattacharyya Lab @moitrayee_lab

science enthusiasts in Pharmacology @Yale studying molecular mechanisms of cell signaling in cancer and neurodegeneration (bhattacharyya-lab.org/)

Joined February 2020
  • Tweets 468
  • Following 1,225
  • Followers 1,148
12 Photos and videos
Pinned Tweet
Bhattacharyya Lab@moitrayee_lab
17 Dec 2025
Preprint from my lab @YalePharm uncovers the molecular mechanisms of uncoupling nociceptive and neurotrophic TrkA signaling using #singleMolecule #microscopy, #cryoEM, #ephys, #signaling, offering a clear blueprint to target this much sought-after pathway! doi.org/10.1101/2025.11.18.6…

1
4
23
2,009
Bhattacharyya Lab retweeted
Avner Schlessinger@SchlessingerLab
Jun 3
New paper from the lab. Using AI-guided modeling and experiments, we identified a hidden allosteric pocket in the cancer kinase PKMYT1. Led by @NHerrington24 in collaboration with @LazarusLab pubs.acs.org/doi/full/10.102…

Allosteric Inhibition of PKMYT1 Induces a Unique, Inactive ATP Binding Site Conformation

The protein kinase PKMYT1 regulates a key cell cycle checkpoint as part of the cell’s DNA-damage repair response, but in cancer, this function can promote tumor cell survival through avoiding mitotic...

pubs.acs.org
2
7
15
521
Bhattacharyya Lab retweeted
Prof. Michael Lin@MichaelLinLab
May 22
For those keeping track of kinases and brain diseases, LRRK2 inhibitor fails to benefit idiopathic Parkinson’s patients. Trial for PD caused by LRRK2 mutations still ongoing. statnews.com/2026/05/21/park…

Closely watched experimental Parkinson’s drug fails key clinical trial

Biogen and Denali Therapeutics said a closely watched experimental therapy for Parkinson’s disease failed to slow the degenerative brain disorder in a randomized trial.

statnews.com
2
4
16
2,166
Bhattacharyya Lab retweeted
Yale Pharmacology@YalePharm
Apr 7
Join us in welcoming our next 2025–2026 Pharmacology Seminar Series speaker, Dr. Aashish Manglik of the University of California, San Francisco. He will be presenting his work at 12 pm on Thursday, April 16th in the Brady Auditorium.
Flyer for the Yale Pharmacology Seminar Series 2025–2026. This flyer indicates that Aashish Manglik, MD, PhD will be presenting his work at 12:00 pm on Thursday, April 16, 2026 in the Brady Auditorium. Dr. Manglik is an Associate Professor of Pharmaceutical Chemistry at the University of California, San Francisco. The title of his talk is "Cracking Codes in Cellular Communication."

ALT Flyer for the Yale Pharmacology Seminar Series 2025–2026. This flyer indicates that Aashish Manglik, MD, PhD will be presenting his work at 12:00 pm on Thursday, April 16, 2026 in the Brady Auditorium. Dr. Manglik is an Associate Professor of Pharmaceutical Chemistry at the University of California, San Francisco. The title of his talk is "Cracking Codes in Cellular Communication."
2
5
339
Bhattacharyya Lab retweeted
proteinsociety
@ProteinSociety
Mar 6
March 17 is the deadline for abstract submission for Open Talks (in every session) and Travel Grants (up to 100) for our 40th Anniversary Symposium in Boston, MA. Don't miss it! Abstract fees are $15 for student members and $30, for non-members. proteinsociety.org
3
4
2,104
Bhattacharyya Lab retweeted
Taekjip Ha@taekjip
Jan 22
Consider applying for this Gordon conference on single molecule approaches to biology! Suliana Manley is the keynote speaker.
Quentin Smith@Q_M_Smith
Jan 22
🔬 Calling all early-career researchers (ECRs) for the GRS Single Molecule Approaches to Biology! 🌎 Location: Les Diablerets, Switzerland 📆 Save the date: June 27-28, 2026 🔗 More information: grc.org/single-molecule-appr… #biology #biophysics #singlemolecule #microscopy #ECR
Visual advertisement providing details for the 2026 Single Molecule Approaches to Biology GRS in Les Diablerets, Switzerland in June 27-28, 2026. Two-day event for early-career single-molecule biophysicists, with a keynote session, 12 selected talks, 2 poster sessions, and mentorship component. For more information contact Alba or Quentin or see the official GRS website.

ALT Visual advertisement providing details for the 2026 Single Molecule Approaches to Biology GRS in Les Diablerets, Switzerland in June 27-28, 2026. Two-day event for early-career single-molecule biophysicists, with a keynote session, 12 selected talks, 2 poster sessions, and mentorship component. For more information contact Alba or Quentin or see the official GRS website.
6
30
4,615
Bhattacharyya Lab retweeted
Mahipal Ganji@mahipal_ganji
Jan 6
🚨 Postdoc Position Open 🚨 Study protein-DNA interactions w/ cutting-edge single-molecule imaging in our lab! Exciting projects perfect for ANRF-NPDF apps. Motivated postdoc candidates: Approach us! Mahipal Ganji ganji@iisc.ac.in ganjilab.org

Home

DNA Biophysics and Chromatin Structure

ganjilab.org
2
22
59
5,820
Super cool work! I can see so many applications!!! Congratulations 🎉
Abhishek Chatterjee@AChemSynBio
Jan 6
Starting 2026 with Quan Pham's paper expanding the chemical toolbox for engineering AAV - New bioorthogonal labeling, including IEDDA, for efficient macromolecule attachment - Incorporation of two different chemistries for dual capsid labeling & much more: onlinelibrary.wiley.com/doi/…
1
1
447
Bhattacharyya Lab retweeted
Vijay Sankaran
@bloodgenes
Jan 2
Delighted to have our work on 🧬 resilience to 🩸cancer led by @GauravA_UK & amazing collaborators, including @KharasLab, published in @ScienceMagazine: science.org/doi/10.1126/scie… 🧵
20
58
320
31,840
Bhattacharyya Lab retweeted
Cell@CellCellPress
27 Dec 2025
In the latest issue! Inhibition of oligomeric BAX by an anti-apoptotic dimer dlvr.it/TQ2MJy
23
74
10,324
Bhattacharyya Lab retweeted
Hồng Minh Triết@atonidascs
20 Dec 2025
Super excited to share our latest finding on the EGFR activation mechanism. In our paper, we found that cholesterol in the inner leaflets of the plasma membrane is essential for ligand dependent EGFR activation. science.org/doi/10.1126/scia…

EGFR activation requires cholesterol interaction at the inner leaflet of the plasma membrane

EGFR activation requires cholesterol interaction at the inner leaflet of the plasma membrane.

science.org
2
6
200
Preprint from my lab @YalePharm uncovers the molecular mechanisms of uncoupling nociceptive and neurotrophic TrkA signaling using #singleMolecule #microscopy, #cryoEM, #ephys, #signaling, offering a clear blueprint to target this much sought-after pathway! doi.org/10.1101/2025.11.18.6…

1
4
23
2,009
Our findings have outsized implications for selective targeting of #ChronicPain without adverse effects on trophic signaling OR treatment of #neurodegeneration without eliciting dose-limiting pain. A detailed step-by-step description of this preprint is coming soon!
1
145
This project was led by the very talented Dr. Shailesh Kumar and Harry Jung in my lab, with outstanding collaborative support from what was truly a dream team! Special thanks to Drs. Shyamal Mosalaganti and Yamuna Krishnan for making this fun!
141
Bhattacharyya Lab retweeted
Lemmon and Ferguson Labs@LemmonFerguson
13 Dec 2025
FDA approves 100th small-molecule kinase inhibitor nature.com/articles/d41573-0…

FDA approves 100th small-molecule kinase inhibitor

Nature Reviews Drug Discovery - Industry is still trawling the kinome for drug targets, 24 years on from the landmark approval of imatinib.

nature.com
2
3
370
Bhattacharyya Lab retweeted
Lemmon and Ferguson Labs@LemmonFerguson
16 Nov 2025
Please join us on Nov 20th at noon in Brady Auditorium to hear about Moi Bhattacharyya's exciting work.
2
7
531
We now provide a molecular framework to uncouple the nociceptive from neurotrophic TrkA signaling, using #singleMolecule #microscopy, #cryoEM, #electrophysiology, #signaling. This finding has outsized implications for selective targeting of chronic pain and neurodegeneration.
119
Bhattacharyya Lab retweeted
Rockefeller University@RockefellerUniv
10 Nov 2025
Researchers in the Vosshall lab have discovered the first evidence of what happens when a female mosquito chooses to mate for the one and only time in her life. We spoke to @leslievosshall and @LeahHouri about their unexpected findings. See the full Q&A:rockefeller.edu/news/38495-w…

1
11
32
3,421
Bhattacharyya Lab retweeted
Bewersdorf Lab@bewersdorflab
16 Oct 2025
Super-resolution single-molecule fluorescence meets quantitative phase contrast! This powerful combo enables ~0.05 nm optical path difference detection, < 20 nm resolution, and continuous live-cell imaging with digital staining, opening new windows into molecular dynamics!🔬
#Microscopy #CellBiology #OI-DIC #SMLM

ALT #Microscopy #CellBiology #OI-DIC #SMLM

Cell Biology J-Club@cell_club
15 Oct 2025
A correlative quantitative phase contrast and fluorescence super-resolution microscope for imaging molecules in their cellular context biorxiv.org/content/10.1101/…
2
2
17
2,577
Bhattacharyya Lab retweeted
Giovanni D'Angelo
@Gio_Dangel0
21 Aug 2025
This is a game changer
André Nadler@nadlerlab
21 May 2024
Here’s the big one: In collaboration with @Honigmann_Lab, @LabShevchenko, Björn Drobot and Martin Hof we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism. biorxiv.org/content/10.1101/…
1
2
9
958
Many congratulations @JunLiuLab for this beautiful work!
Jun Liu Lab@JunLiuLab
30 Jun 2025
Exciting findings from @JunLiuLab #postdoc @YueJianUSTC @YaleMed Architecture and activation of the Legionella Dot/Icm type IVB secretion machine #cryoEM #cryoET #Legionella biorxiv.org/content/10.1101/…
433
Load more