Interleukin-10 Autoantibodies and HLA-DRB1*01:03 in Inflammatory Bowel Disease | New England Journal of Medicine nejm.org/doi/full/10.1056/NE… Maybe one of the most important IBD papers - 3-5% of CD disease caused by IL10 autoantibodies... B-cell therapies???

A whole genome sequencing assay named HPV-DeepSeek sniffs out signs of residual disease after surgery in patients with #HPV head and neck cancer, and detects recurrence earlier than digital PCR and standard clinical criteria. @FadenLab @BIDharvardOHNS scim.ag/3S52VLF

A landmark study shows that latent #HIV can convert CD4 T cells to CD8 T cells and identifies the latter as a previously overlooked component of the viral reservoir—a surprising finding with critical implications for HIV cure efforts. @sysu_1924 scim.ag/4uklbhB

In the last year, we’ve: ✅Developed a next-generation in vivo CAR-T platform of high specificity & efficacy ✅Entered the second half of recruitment in our first in-human clinical trial, CARxALL ✅Built and strengthened collaborations with research institutions & global partners

Wow just heard about new clinical trials of a new drug for hep B infection at the European HIV hepatitis meeting - antisense oligo nucleotides showing promising results in those already taking nucleotide/side inhibitors. And for hep D a new entry inhibitor.@hkjcghi @MedCambridge

1/ Congratulations to our UK colleagues on this landmark @NEJM study: “Interleukin 10 Autoantibodies and HLA DRB1*01:03 in IBD”nejm.org/doi/full/10.1056/NE… A powerful example of how discoveries from rare monogenic #VEOIBD can illuminate mechanisms relevant to common #IBD.

I am super proud to post a BEAUTIFUL review in Nature Reviews Microbiology that started as Dinh's PhD thesis introduction, and matured over a two year period, into a view on how he studies RNA virus evolution and how those concepts can be used in applied virology. Dinh Tran joined my group as a PhD student coming from a background of solid evolutionary sciences and population genetics, and trying to transform his wisdom to us and how we develop antiviral approaches. He is now a postdoctoral fellow, applying all these concepts to his own research program. This is a very useful review, I hope you enjoy it. It is written for a broad audience, for students and scientists in the field and in related fields. rdcu.be/fiHde Share it with everyone!

Today my laboratory is thrilled to announce a major breakthrough in the fight against the common cold and other diseases like hand,foot, and mouth disease acute flaccid myelitis caused by picornaviruses. We present the first structure of picornaviral 2C, bound to ssRNA (1/n)

don’t type pymol commands urself, now there’s co-pymol available for claude code and cursor ⬇️

Interactome mapping has been stuck at a few hundred baits over months. HIP-MS changes the regime: ~10,000 pulldowns/week at 500 samples/day, fully automated. A new era for interactomics — and a precursor to high-throughput proteomics writ large. doi.org/10.64898/2026.06.03.…

Lipid droplets are key immunometabolic platforms in early antiviral defence @NatureComms @ebony_monson @TimetogoZ @Latrobe @JayLaws15 @HelbigLab nature.com/articles/s41467-0…

📝 A new @MolecularCell study led by Dr. Leo James demonstrate that TRIM21 rapidly intercepts antibody-pathogen complexes, leading to ubiquitin ligase activation. bit.ly/4odCa3J They propose that TRIM21 evolved through competition with pathogens to induce autophagy of diverse and complex substrates. 🦠 #OpenAccess

Can AI predict which flu strains will jump to humans? New preprint uses protein language models to forecast influenza host tropism & zoonotic risk, across 9 animal families. No subtype assumptions. Full proteome. 90% accuracy. A step toward proactive pandemic prevention.

1/5 Cell identity is written in the proteome, not in the DNA, and not always in the RNA. Out on bioRxiv today: The first cell type-resolved, MS-based proteomic atlas of the human body. biorxiv.org/content/10.64898…

Comprehensive review on COVID-19: etiology, pathogenicity, and treatment. September 2025 frontiersin.org/journals/med…

Want to do a PhD combining cryo-EM, AI-driven binder design, and deep virology in a cutting-edge environment and in an international team? We're hiring @CSSB_Hamburg 🔬 You: curious, rigorous, MSc in biochem, biophysics, virology, or related. Interested? DM me. Please RT 🙏 #PhDposition #cryoEM #virology

The ISG Atlas: a loss-of-function analysis characterizes antiviral properties of interferon stimulated genes nature.com/articles/s41467-0… @NatureComms @a_pichlmair 🇩🇪

Acaban de secuenciar al virus que ha causado el brote de Hanta en el crucero. virological.org/t/complete-s… Resulta que es prácticamente idéntico al virus que causó la epidemia que duró 4 meses en Argentina en 2018. nejm.org/doi/10.1056/NEJMoa2… No es un virus nuevo ni su transmisión de 🧵

🧬 New paper out in @Nature! We used CRISPR to selectively kill cancer cells based on a single-letter mutation in their RNA. The story I want to highlight: KRAS — one of the most notorious drivers of human cancer. A short thread on what we found 🧵

Autoantibodies cause autoimmune disease, shape infection outcomes, and alter cancer immunotherapy. But what role might they play in neuropsychiatric disease? In our new preprint, Katlyn Nemani and @JillianRJaycox take on this question in schizophrenia. 🧵 biorxiv.org/content/10.64898…