Assistant member @MoffittNews studying redox biology, cancer metabolism and mitochondria.
Joined August 2023
- Tweets 303
- Following 339
- Followers 496
- Likes 681
8 Photos and videos
Chang Jiang 姜畅 retweeted
Looking for a postdoc? We are recruiting scientists who are finishing their PhD to study how metabolism shapes cancer progression, immunity, and therapeutic resistance. Recent highlight: our Nature paper on αKG tiny.cc/ur15101. Learn more at airdlab.com.
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Chang Jiang 姜畅 retweeted
A membrane homeostatic response to lipid overload coordinates fatty acid metabolism biorxiv.org/content/10.64898…
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Chang Jiang 姜畅 retweeted
Jun 11
NRF2-mediated inhibition of alveolar macrophage MHC II expression during Mycobacterium tuberculosis infection dlvr.it/TT02dT
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Chang Jiang 姜畅 retweeted
Jun 12
Online Now: RNA reinforces condensate nucleation on chromatin to amplify oncogenic transcription dlvr.it/TT0yzt
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Chang Jiang 姜畅 retweeted
Jun 12
Excited to share that our preprint 'RNA reinforces condensate nucleation on chromatin to amplify oncogenic transcription' is now online @MolecularCell cell.com/molecular-cell/full… @PennMedCSO @PennCancer @PennEpiInst
4 Aug 2025
(1/n) Excited to share our new preprint! We uncover that RNA actively promotes nucleation and function of pathogenic condensates, amplifying locus-specific oncogenic transcription and promoting tumorigenesis. #epigenetics #condensates #cancer #RNA biorxiv.org/content/10.1101/…
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Chang Jiang 姜畅 retweeted
Jun 11
RAS-ing the bar in the treatment of KRAS-mutant cholangiocarcinoma dlvr.it/TT0SfW
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Chang Jiang 姜畅 retweeted
Jun 10
Tissue tension fosters macrophage-driven lipid peroxidation-induced DNA damage dlvr.it/TSzVNC
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Chang Jiang 姜畅 retweeted
Hypoxia-driven lncRNA SHIELD promotes GPX4 translation and protects against ferroptosis in hepatocellular carcinoma dlvr.it/TSv82y
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Chang Jiang 姜畅 retweeted
Congrats to my friend and ex-@YatrikShahLab lab mate @ChestaJain5 on this impressive work!
New! Online now: Iron-addicted colorectal cancers exploit heme-complex II axis to resist oxidative cell death dlvr.it/TSlWK5
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Chang Jiang 姜畅 retweeted
Excited to share our new @biorxivpreprint from the @BradyLab led by Santanu Ghosh.
“Mitochondrial copper stabilizes lipoylated TCA cycle proteins to sustain metabolism and proliferation”
biorxiv.org/content/10.64898…
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Chang Jiang 姜畅 retweeted
Excited to share our new @biorxivpreprint from the @BradyLab & @PaulTitchenell lab on MASH, phosphatidylcholine metabolism, and copper biology with @JaclynE_x8 &
biorxiv.org/content/10.64898…
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Chang Jiang 姜畅 retweeted
May 2
Our lab is expanding and hiring both a postdoc and staff scientist! We study how metabolism and cell cycle states drive tumor progression, therapy response, and immune interactions. Philly is a great place to live and do research! See more at: airdlab.com.
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Apr 19
Congratulations! ❤️
Apr 17
Our new work by @shanshanliu1218 and @gadmark addresses a fundamental question: how does ER maintain its unique oxidizing environment, while rest of the cell is reducing? Here, we identify SLC33A1 as the major ER GSSG exporter in mammalian cells. nature.com/articles/s41556-0…
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Chang Jiang 姜畅 retweeted
Apr 17
Our new work by @shanshanliu1218 and @gadmark addresses a fundamental question: how does ER maintain its unique oxidizing environment, while rest of the cell is reducing? Here, we identify SLC33A1 as the major ER GSSG exporter in mammalian cells. nature.com/articles/s41556-0…
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Chang Jiang 姜畅 retweeted
Apr 17
Check out this amazing work by @shanshanliu1218 and @gadmark !
Thrilled to share our new paper: SLC33A1 is the long-sought ER GSSG exporter, maintaining redox homeostasis in the ER. Huge congratulations to my co-first author @shanshanliu1218 and my PIs @KivancBirsoy and @HiteLabMSKCC for leading this work. nature.com/articles/s41556-0… 🧵 1/9
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Congratulations Yuyang! 👏
Apr 3
Excited to share our work uncovering an unexpected player in ER protein homeostasis biorxiv.org/content/10.64898…
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Chang Jiang 姜畅 retweeted
New! Online now: Tissue and CD4 T cell subset dependence on the amino acid transporter SLC38A1 dlvr.it/TRfVjQ
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Chang Jiang 姜畅 retweeted
Mar 13
1/3 Thrilled to see our paper led by Kirandeep Deol is out! We used CRISPR screens to uncover regulators of the ferroptosis suppressor FSP1. key discovery: vitamin B2 metabolism stabilizes FSP1 via FAD, revealing a new way vitamins regulate ferroptosis.
nature.com/articles/s41594-0…
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Chang Jiang 姜畅 retweeted
Neutrophil-mediated anti-tumoral effects of caloric restriction dlvr.it/TRQxhh
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