Professor @UMich_MCDB dept of @umichLSA College at the University of Michigan (@umich) Views/posts are JK's
Joined April 2019
- Tweets 2,250
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- Likes 6,830
8 Photos and videos
JK Nandakumar lab retweeted
May 28
Beyond thrilled to welcome our inaugural cohort of #CechFellows — 176 talented undergrads who will spend 9 weeks this summer contributing to real scientific discovery alongside leading HHMI scientists across the country, & at our Janelia Research Campus! hhmi.news/4dBq7tb
ALT Summer undergraduate researchers in the lab of Dr. Xin Chen, HHMI Investigator.
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JK Nandakumar lab retweeted
May 6
For undergrad students, a single summer of research can be transformative.
The @UMich_MCDB's Horizons Summer Research Internship Program is dedicated to expanding opportunities for students: bit.ly/4f7zRwh
ALT Sydney Richardson
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JK Nandakumar lab retweeted
20 Aug 2025
Happy to share our community note published in Nature Communications. In this 14-page article (34 authors from 9 countries), we discuss current practices in biomolecular phase separation and hope it will be useful to the biomolecular condensate community.
nature.com/articles/s41467-0…
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JK Nandakumar lab retweeted
22 Aug 2025
MCDB Opens Search for Faculty | U-M LSA Molecular, Cellular, and Developmental Biology (MCDB) lsa.umich.edu/mcdb/news-even…
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Tenure-track assistant professor position in neuroscience or physiology at University of Michigan LSA Molecular, Cellular, and Developmental Biology (MCDB) lsa.umich.edu/mcdb/news-even…
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JK Nandakumar lab retweeted
12 Jun 2025
BBO-10203 is currently being evaluated in the Phase 1 BREAKER-101 trial (NCT06625775) in patients with HER2 and HR /HER2- breast cancer, KRAS mutant colorectal cancer, and KRAS mutant non-small cell lung cancer.
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JK Nandakumar lab retweeted
12 Jun 2025
This publication describes how BBO-10203 disrupts the RAS–PI3Kα interaction without impairing insulin signaling, resulting in broad antitumor activity across multiple cancer models. It also shows enhanced efficacy in combination with other targeted agents.
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JK Nandakumar lab retweeted
12 Jun 2025
We are excited to share our collaborative work on the first-in-class RAS:PI3Kα breaker, BBO-10203, which has now been published online in @ScienceMagazine !
🔗 Read the full article here: science.org/doi/10.1126/scie…
BridgeBio Oncology Therapeutics (BBOT) @FredNatLab @Livermore_Lab
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JK Nandakumar lab retweeted
9 Jun 2025
Happy to share our new paper! 🎉
We show that #cGAS–#STING inflammation drives premature #aging in response to telomere shortening in #zebrafish.
🧬 Telomere-driven aging occurs in 2 stages:
1️⃣ Senescence, inflammaging, cancer
2️⃣ Genome instability, death
tinyurl.com/34rhn67z
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JK Nandakumar lab retweeted
10 Dec 2024
New paper from the lab. We collaborated with the legendary Stuart Kornfeld lab to study the molecular mechanisms of how TMEM251/LYSET regulates the M6P pathway.
Molecular Insights into the Regulation of GNPTAB by TMEM251 biorxiv.org/content/10.1101/…
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JK Nandakumar lab retweeted
7 Dec 2024
Our structural-guided insights contributed to the design of BBO-8520, a first-in-class dual inhibitor targeting both GTP-bound (ON) and GDP-bound (OFF) KRAS G12C.
Excited to see this work now published in @CD_AACR! @FredNatLab @BridgeBioPharma
6 Dec 2024
Now online in @CD_AACR: Discovery of BBO-8520, a First-in-Class Direct & Covalent Dual Inhibitor of GTP-Bound (ON) & GDP-Bound (OFF) KRAS G12C - by Anna Maciag, James Stice, Bin Wang, @frankpmccormick, Pedro Beltran, et al. doi.org/10.1158/2159-8290.CD… @FredNatLab @BridgeBioPharma
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JK Nandakumar lab retweeted
3 Dec 2024
Last week, we said farewell to the first postdoc of our lab, George Ghanim @AutomneNine who will start his own lab at Princeton in 2025. We are proud of you and thankful for all your contributions. Please watch out for exciting future opportunities from the Ghanim lab!
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JK Nandakumar lab retweeted
30 Nov 2024
“We highlight the differences between human and mouse telomere biology that may contribute to discrepancies between human diseases and mouse models. Finally, we discuss recent efforts to generate new ‘humanized’ mouse models to better model human telomere biology.” 👇
29 Nov 2024
Now Online: Telomere function and regulation from mouse models to human ageing and disease go.nature.com/3D2Cu1m
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JK Nandakumar lab retweeted
29 Nov 2024
In @ScienceMagazine - great collaborative work w/ @AlbertW_Lab & @RappsilberLab showing that bacterial RNA polymerase can thread nascent mRNA into the pioneering ribosome from two sides for higher translation initiation efficiency - target for antibiotics?
eurekalert.org/news-releases…
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JK Nandakumar lab retweeted
28 Nov 2024
Happy to share Elise and Tarah’s work on building a facile selection system to engineer E. coli leucyl synthetase for site-specific incorporation of many new noncanonical amino acids into proteins in eukaryotes, including ornithine and N-acetyl-methyllysine!
28 Nov 2024
Optimized directed evolution of E. coli leucyl-tRNA synthetase adds many noncanonical amino acids into the eukaryotic genetic code ... biorxiv.org/cgi/content/shor… #biorxiv_synbio
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JK Nandakumar lab retweeted
7 Nov 2024
MCDB's Kozik Honored by Microbiology Society | U-M LSA Molecular, Cellular, and Developmental Biology (MCDB) lsa.umich.edu/mcdb/news-even…
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JK Nandakumar lab retweeted
8 Oct 2024
In our #RNA focus issue, we invited viewpoints from three groups on the controversy over PRC2-RNA interactions and asked how they might reconcile the findings on the topic. dlvr.it/TF7h5W dlvr.it/TF7h5h dlvr.it/TF7h6G
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JK Nandakumar lab retweeted
9 Oct 2024
Ratan Tata ’59, B.Arch. ’62, the university’s most generous international donor and one of India's most respected business leaders and philanthropists, passed Oct. 9. We will remember his legacy of transformative giving to Cornell.
news.cornell.edu/stories/202…
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1/8 ❄️🔬Excited to share our latest work published in @NatureComms! Led by @kaitlyn_m_abe and in colab with @GrantCryoEMLab, we've discovered a simple, cost-effective way to mitigate sample damage at the air-water interface during grid preparation. #CryoEM rdcu.be/dSWfn
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JK Nandakumar lab retweeted
31 Aug 2024
I've submitted my first ever tenure-track job application. Officially, I'm on tenure-track job market. My major interest is membrane protein structure & function. As a first-gen immigrant scientist, even being able to apply is a long way from a working-class family home in India.
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