1/🧵 New Paper Alert!! I am very excited to introduce the idea of Meta-Synergy in nanomedicine-out in @JCRnEDITORS!! sciencedirect.com/science/ar… led by @AzaguryDana together with @Ben_JFG @HarrisYuval at @TechnionLive

RevMed with huge news for pancreatic cancer (daraxonrasib). The headline is hard to ignore 👀 • Median OS 13.2 vs 6.7 months • HR ~0.4 📉 • Activity across KRAS variants (not just G12C) • Manageable safety If that signal is real, this isn’t incremental. It changes how we think about KRAS. But—caveat applies ⚠️ This is a press release! PR as a rule is rosier than real data. Still… an OS HR like that gets your attention. Feels like we may be moving from mutation-specific inhibition → broader KRAS control. That’s the difference between niche utility and something that touches CRC, pancreas, lung… everything we see. Now we wait for the data behind the headline. @TheGutOncLab @OncoAlert @Onco_Nexus ir.revmed.com/news-releases/…

Teachers weren't in our roadmap. 1.3 million education apps later, they're our biggest surprise. 870,000 of those builders are teachers, administrators, or students. It makes sense when you think about it. Teachers have the most specific, daily, unfixable problems. No edtech product fits the way their particular school runs. They've never had any way to build the exact tool they need. A teacher doesn't need Salesforce. He needs a parent communication app that works exactly the way his school does. A professor doesn't need a $10,000 LMS. She needs a course tracker that matches her grading system. A recent post by @tibo_maker made me think about it, and honestly, this might be the use case I'm most proud of.

Let's take a break from both war and AI, to discuss dithering in pixel graphics in games. in particular how it was invented, because I think it is a cool story. the pictures show dithered EGA graphics from the game LOOM, which was apparently the first game to use this technique.

🚨 New must-read from the AG Rauh group! Lessons from Structural Biology for Understanding Drug Resistance in Gastrointestinal Stromal Tumors (GIST)” by Mancino et al. 🔬🧬 👉 pubs.acs.org/doi/10.1021/acs… #GIST #CancerResearch #DrugResistance #MedChem #Oncology

I think one of the unexplored AI in movies is the kind in westworld(s3 the huge sphere) used to sync people's life path to reach optimal society. I would love to see it in a smaller scale.

🟢 Spotify: open.spotify.com/album/0Otsy… 🟦 Bandcamp: encapsulatedcapsula.bandcamp… ☁️ SoundCloud: soundcloud.com/capsula-israe…

The q.e.d feedback that you get when you run your paper via @biorxivpreprint.bsky.social is not posted there, it's private and for your eyes only. In the future we want to create a report that you'll be able to attach to your preprint like a cover letter (it's all opt in of course)

Excited to release BoltzGen which brings SOTA folding performance to binder design! The best part of this project has been collaborating with many leading biologists who tested BoltzGen at an unprecedented scale, showing success on many novel targets and pushing its limits! 🧵..

Remarkable!

I think the obsession with randomized controlled trials as the default of "doing science" has probably set us back a few decades

When we came to see our destroyed labs hit by an Iranian missile, we found that a piano had survived @WeizmannScience

My lab at @WeizmannScience was completely demolished by the Iranian missile a few days ago. This is hard and sad as nothing was left to save. We study heart regeneration and regenerative medicine. As such, we will regenerate, regrow and rebuild. The one thing that wasn't gone is our motivation said one of my student. It is true. Here, I would like to thank many of my friends around the globe that offer their help, space and support. I really appreciate that.

When 1 1 > 2 ✌️ In this Analysis, we show that (1) nanomedicines are useful to improve the efficacy of multi-drug cancer therapy, and that (2) co-delivering two drugs in one NP produces better outcomes than co-administering two single-drug-loaded NP 👉 rdcu.be/el86N

Some perspective amidst the news

What is considered to be the holy grail of biology—the virtual cell—now has potential for being actualized. erictopol.substack.com/p/the…

my unfinished paper watching me scrolling twitter

#GI25 Is it the hardest to pronounce name of any antibody? Yes. It is also probably the best new treatment for GI malignancies? Also, probably yes. Daraxonrasib, pan-KRASi Amazing responses in second line PDAC Making the undruggable druggable. (Someone please teach me how to pronounce this.)

This is crazy!!