Cell biologist with an interest in pretty much everything
Joined March 2017
- Tweets 1,256
- Following 326
- Followers 7,631
- Likes 6,036
109 Photos and videos
Lydia Finley retweeted
May 26
We are thrilled to share our latest work out today @Dev_Cell! Appendiceal adenocarcinoma (AC) is a rare, aggressive cancer that frequently spreads to the peritoneum. Until now, lack of robust preclinical models has severely limited drug discovery. cell.com/developmental-cell/…🧵👇 🔗
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Lydia Finley retweeted
May 21
Congratulations to Dr. Shimaa Soliman and colleagues in our @ShilatifardLab as they performed detailed biochemical studies of chromatin and RNAPII under normoxic and hypoxic conditions and identified hypoxia-responsive transcriptional axis linking P-TEFb, BHLHE40, and nuclear-localized Tim8–Tim13 complexes. Our study shows that chromatin-associated interaction is required for efficient hypoxic gene transcription and operates at least partly independently of canonical HIF signaling. Disrupting Tim8–Tim13 or silencing BHLHE40 impairs acute hypoxia responses. These findings identify a new regulatory mechanism coordinating RNAPII pause release during hypoxic stress. #Hypoxia #Transcription #CancerBiology #RNApolII #PTEFb @NU_BMG_SQE @CellPressNews @ScienceMagazine @ScienceAdvances @Nature @NatMetabolism @MolecularCell @NUFeinbergMed science.org/doi/10.1126/scia…
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Lydia Finley retweeted
New review from our group taking a critical look at OxPhos as a cancer target......and suggestions for where the field goes next. Published in @Biochem_Journal
portlandpress.com/biochemj/a…
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May 15
“Uncertainly isn’t a flaw in what we do. It is what we do.”
Check out Juliana Delgado’s commencement speech @MSKCancerCenter
An ode to becoming a scientist. A reminder that questions are power, doubt is discipline, and the journey really is the point 🌟f.io/KVQKeHjT
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May 15
Overall, yesterday was really special day @MSKCancerCenter celebrating @GSKGradSchool graduates, including our very own Abby Xie!! Congratulations Dr. Xie!
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May 15
AND to our newest @GSKGradSchool student in the lab, Monika Komza, on her fellowship award! Feeling grateful to spend an afternoon celebrating the amazing scientists who move through our labs and on to new horizons!
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Lydia Finley retweeted
New out this week from our lab in @NatMetabolism. We measured dynamic aspartate changes following mitochondrial inhibition, finding that SDH inhibition causes a counterintuitive rebound effect mediated by succinate impairing pyrimidine synthesis.
nature.com/articles/s42255-0…
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Lydia Finley retweeted
Check out our Spotlight in @MolecularCell on @lydfinley lab's recent work on Aconitase 2 and its protective role against impaired cell fitness and ISR activation due to mitochondrial citrate accumulation authors.elsevier.com/c/1n3Nn…
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Lydia Finley retweeted
Thank you to organisers Lydia Finley @lydfinley and Wilhelm Palm @WilhelmPalm and everyone who joined us at this week's Workshop on 'Revisiting Metabolic Fundamentals'
biologists.com/workshops
#BiologistsWorkshops
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Lydia Finley retweeted
@shouval_lab @SnehaPramod @hagargir and I reflect on the work of the ✨ TME community in a new review re fibroblasts in cancer @NatureCancer. 2025 was my yr to 🩵 the distraction of writing (IYKYK), so thx to all whose discoveries made this so gratifying. nature.com/articles/s43018-0…
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Thrilled to share our new paper: SLC33A1 is the long-sought ER GSSG exporter, maintaining redox homeostasis in the ER. Huge congratulations to my co-first author @shanshanliu1218 and my PIs @KivancBirsoy and @HiteLabMSKCC for leading this work. nature.com/articles/s41556-0… 🧵 1/9
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Lydia Finley retweeted
Pleased to share our recent work out today in @NatMetabolism. This study addresses a longstanding mystery - NRF2-driven cancers increase cysteine acquisition (via xCT) by ~5x - so where does all that cysteine go?
Excess cysteine drives conjugate formation and impairs proliferation of NRF2-activated cancer cells dlvr.it/TRwLTT
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Lydia Finley retweeted
Mar 24
🗽Another inspiring Cancer Metabolism and Signaling Symposium @NYASciences. Thanks to the speakers & participants!
@lydfinley @RichPossemato
@lab_manning @bensahralab @MarcusDGon @airdlab @KanarekNaama @JaviGBermudez @SantoshVardhana, et al
You would have enjoyed it, Steven. We missed ya ✌🏼
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Lydia Finley retweeted
Mar 20
The first approved GLP1 (Byetta) came from a desert reptile, the Gila monster. Inspired by this, our work on Burmese pythons 🐍🐍 is now out @NatMetabolism. An “extreme”-ly fun collaboration with Leinwand and @DrYongXu1. Congratulations @Shuke_Xiao!
nature.com/articles/s42255-0…
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Lydia Finley retweeted
I’m excited to share new work out of the lab at @NYULangone led by @kenjifujihara! We took a first principles approach to evaluating #ferroptosis induction for cancer therapy via targeting the SLC7A11-glutathione-GPX4 axis. biorxiv.org/content/10.64898…
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Lydia Finley retweeted
#NatMetabPicks | In @CellCellPress led by @lydfinley (@mskcancercenter)
Citrate clearance is an essential function of the TCA cycle via the activity of aconitase 2.
cell.com/cell/fulltext/S0092…
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Lydia Finley retweeted
Metastasis kills most cancer patients and grows from invisible seeds. How do these seeds escape from attack by immune cells? These seeds harness stress hormones!🤯
thanks to @nyscf @parkerici for their support. Today at @Nature nature.com/articles/s41586-0…
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Feb 27
Out today in @cellcellpress new work from the lab led by Abby Xie and @jules_stef asks, when and why do cells use the TCA cycle?
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Feb 27
Huge congratulations to Abby and Julia for their incredible collaborative effort. I am also very grateful to our funders who’ve enabled our basic science studies into fundamental metabolic pathways especially @nyscf @pershingsqfdn
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Feb 27
Many thanks also to all lab members who helped along the way incl. Sangita, Angela, Anna, @__btjackson, @paigearnold2, @kiparas21, Maider, Monika, and friends and colleagues at @mskcancercenter!
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