New publication from the lab @pnas . With the collaboration of Dr. Ping Kang @pingkang0, we uncovered how developmental NF-kB signaling links developmental timing (time to maturity) to lifespan😊😊pnas.org/doi/10.1073/pnas.24…

Why do some organs age faster than others? By integrating multi-omics and genetic data, researchers mapped organ-specific aging clocks and uncovered distinct molecular pathways driving heterogeneous aging across the body. #Impactfulpapers @CellGenomics dlvr.it/TT0KPz

This is biblical. A woman in her eighties. Ten years into Alzheimer's. Hadn't spoken a full sentence in five years. Takes one, 5 gram dose of psilocybin. She slept 19 hours and woke up and spoke for hours about her life, recognized family and held real conversations. She regained bladder control after five years, walked on her own. and dressed herself. Gains held for weeks.

C盘最恶心的四大害虫 随便一清就是几十G

AI of radiologist read as normal mammograms shown to detect high-risk of breast cancer out several years "Artificial intelligence scores from sequential mammograms in individuals diagnosed with breast cancer showed elevated scores up to 10 years before diagnosis" a retrospective study, but supported by prospective study in 3-5 year time horizon pubs.rsna.org/doi/10.1148/ra… erictopol.substack.com/p/why…

Join Dr. Regina Barzilay for the 2026 Joseph Leiter NLM/MLA Lecture on how AI is revolutionizing disease discovery! 🧬💻 🗓️ June 10, 2026 | 2-3 PM ET 🔗 Join here: bit.ly/4v0FSQK #MLA26

当女子加班回家，却看到家人没有等自己一起吃饭，下一秒……这就是婚姻的意义吧！

Really interesting study showing that disrupting vgll3 (a gene associated with age at maturity in humans) accelerates growth and maturation in male killifish but shortens lifespan. A striking example of antagonistic pleiotropy 👀

五分钟学会八字

In a paper just published in @sciencemagazine, we teamed up with @teichlab to construct the most detailed atlas to date of hormone production and action in humans at cellular resolution. (1/8) Link: science.org/doi/10.1126/scie…

耿同学被招安了。他的目的达到了，他的本硕母校吉林大学把他叫了回去，说是答应安排他本校工作。他答应暂停打假。估计是有关部门和好多院校与吉大商量的办法。不能让他这么搞下去了。

Just published @Nature Very impressive study of gene expression and hallmarks of aging across 4 mammalian species (including humans), by @gladyshev_lab. Transcriptomic clocks add to epigenetic, organ and cellular clocks for predicting health outcomes. Example of a few proteins found with prediction of disease/event risk in Figure below nature.com/articles/s41586-0…

From whole-body to organ-specific biological age clocks nature.com/articles/s43587-0…

I’m thrilled to share that our paper is out in Molecular Cell! We developed Ribo-Tweezer, a new technology that lets us rapidly and reversibly remove specific proteins from mature ribosomes to ask what they actually do in translation.

I’m thrilled to announce my new podcast, Longevity Science with Matt Kaeberlein. Episode 1 is now live and takes a deep dive into the story of dinitrophenol (DNP) — an experimental weight loss drug linked to hundreds of deaths and a cautionary reminder of what can happen when enthusiasm for new therapies gets ahead of the science. Episode 2 drops Friday and features a Longevity Roundtable with @BKennedy_aging and @docmranney . We discuss proactive healthcare, rapamycin, peptides, epigenetic reprogramming, biological age testing, and where the field of longevity medicine may be headed next. My goal with this channel is simple: thoughtful, evidence-based conversations that separate signal from noise in the rapidly evolving world of longevity science. I hope you’ll check it out — and subscribe on YouTube, Spotify, or wherever you listen to podcasts. YouTube: youtube.com/@mkaeberlein Spotify: open.spotify.com/show/7DRRH5…

NAD probably doesn't actually decline with age. This is one of the problems in NAD-world that I've been warning about for years. I'm glad to see it finally reaching publication. nature.com/articles/s42255-0… The myth that NAD levels broadly change with age in humans and other animals has been propagated by some high-profile people in the field, both in the scientific literature (mostly review articles not real data, which should tell you something) and in the pop-sci podcast world. This has generated hundreds of millions of dollars in sales for NAD precursors and hundreds of millions of dollars in grant funding for those investigators. To be clear, NAD biology is real and important. There are likely specific disease states, tissues, or individuals where NAD availability becomes limiting and where interventions targeting NAD metabolism may prove useful. But that is very different from the much broader claim that declining NAD is a universal driver of normal aging in otherwise healthy people. The evidence increasingly suggests that NAD precursors like NR and NMN do not extend lifespan in mice under standard conditions and likely provide limited or no meaningful benefit to the average healthy person. This is a good reminder of how science should work. Strong claims require strong evidence, especially when they become the basis for major commercial industries and public health narratives. Aging biology is complex, and we need to be careful not to confuse plausible mechanisms with demonstrated outcomes.

Today in @Nature, we report MouseMapper: foundation-model AI to map disease perturbations across the entire mouse body cell-by-cell. In obesity, it revealed body-wide inflammation & unexpected facial nerve damage. 🧵👇🔉 nature.com/articles/s41586-0… led by @Dorie00 & @yingchen733

Albumin in urine, even as low as 1.1mg/mmol, is an independent risk factor for cardiovascular diseases , even in healthy individuals without any other risk factors such as diabetes etc

How do mitochondrial ribosomes keep pace with membrane insertion? We address this question in our paper “Membrane insertion of mitochondrial-encoded proteins regulates ribosome decoding speed,” now out in Nature Structural & Molecular Biology (Link).

I wrote this piece to promote thoughtful, respectful, and rational engagement with controversial science topics. I hope it fosters constructive dialogue in the scientific community—thank you for reading and sharing 🙏🏼 @NatRevImmunol nature.com/articles/s41577-0…