Life Science Venture Capitalist @ForbionLifeSci | Ph.D. in Stem Cell Biology & Medicine from @Cambridge_Uni @ReikLab
Joined February 2017
- Tweets 93
- Following 444
- Followers 263
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5 Photos and videos
Tim Lohoff retweeted
8 Apr 2024
New preprint! π¨@KeckMedicineUSC @uzh_irem
We started with the simple question: What happens when we transplant stem cells into a mouse model of #stroke, and what are the interactions between graft and host?
Took us only 5 yrs to find outπ:
biorxiv.org/content/10.1101/β¦
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New preprint! π₯³
biorxiv.org/content/10.1101/β¦
Led by @AledJohnParry & @ChristelKrueger we asked why #DNAmethylation and oxidation often target overlapping genomic regions at the exit of #pluripotency.
Great collaboration with @Tim_Lohoff, @StevenWingett & @stefanschoenfe1.
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29 Sep 2022
Happy to see another piece of my PhD work published in @GenomeBiology! π₯³ Amazing collaboration with @RArgelaguet and Stephen Clark πͺ#DreamTeam Big thanks to everybody involved @ReikLab @SCICambridge @Cambridge_Uni @BabrahamInst! Finally, check out the great tweetorial below π:
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1 Aug 2022
Great work @rust_ruslan and team! ππ
1 Aug 2022
Preprint π¨ How does immune suppression alter the molecular 𧬠and anatomical π§ roadmap of #stroke pathology?
We detect distinct changes in different pharmacological and genetic immunodeficient models of stroked mice πβ‘οΈπ
Read more here: biorxiv.org/content/10.1101/β¦
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20 Jan 2022
Wow π€― Congratulations @felix_lansing and team π Amazing work. Looking forward to following the path of designer-recombinases towards the clinic π©ΈπͺπΌ Keep the exciting work up! π Check out the great tweetorial below π
20 Jan 2022
Our work just got published in @NatureComms. We developed a dual designer-recombinase system that efficiently corrects a 140 kb inversion frequently found in patients with severe Hemophilia A. 1/11 @BuchholzLab_TUD @TakebeLab @tudresden_de @Medizin_TUD
rdcu.be/cFmeD
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Tim Lohoff retweeted
30 Sep 2021
Our work is out in @ScienceMagazine! Using integrated spatial genomics technology, we have extensively investigated the single-cell nuclear architecture across cell types in the mouse brain cortex with a great team @LongCai_Lab @gc_yuan @swzheng29 #seqFISH
science.org/doi/10.1126/scieβ¦
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Tim Lohoff retweeted
13 Sep 2021
Incredibly happy to share that our work, co-led with @Tim_Lohoff is now available online at @NatureBiotech π
Feeling very grateful to everyone who was involved in this project π
Explore the data here: marionilab.cruk.cam.ac.uk/Spβ¦
7 Sep 2021
Integration of spatial and single-cell transcriptomic data elucidates mouse organogenesis go.nature.com/3DRM6rY
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Paper alert! π By combining SeqFISH and scRNA-seq data we've generated a spatially-resolved map of cell types and gene expression in the early mouse embryo. doi.org/10.1038/s41587-021-0β¦
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Tim Lohoff retweeted
7 Sep 2021
Our work "Integration of spatial and single-cell transcriptomic data elucidates mouse organogenesis" is now out at @NatureBiotech ! Congratulations to all the authors! nature.com/articles/s41587-0β¦ #seqfish #spatial #singlecell #transcriptomics
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Tim Lohoff retweeted
7 Sep 2021
Integration of spatial and single-cell transcriptomic data elucidates mouse organogenesis go.nature.com/3DRM6rY
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13 Aug 2021
Impressive and important work π Congratulations to @rust_ruslan and all other authors! π€©π₯³ check it out ππ₯
12 Aug 2021
Preprint alert!π¨ We as neuroscientists highly depend on behavioral testing in rodents π. Still, assessing motor function or recovery can be so challengingβ‘οΈ.
We aimed to change that using #deeplearning @DeepLabCut assisted 3D behavioral profiling
biorxiv.org/content/10.1101/β¦ π§΅1/
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Tim Lohoff retweeted
27 Apr 2021
Happy to share our latest preprint for imaging-based single-cell multimodal measurements to understand nuclear architecture in mouse brain cortex!
Integrated spatial genomics in tissues reveals invariant and cell type dependent nuclear architecture biorxiv.org/content/10.1101/β¦
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Tim Lohoff retweeted
25 Mar 2021
We are delighted to announce that Professor Wolf Reik has been appointed Director of the Babraham Institute, following an open and international search.
Read the full announcement here:
ow.ly/mXhb50E8930
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Job alert! We're looking for three postdoctoral researchers to lead exciting projects investigating the #epigenetic regulation underlying lineage specification during #development. Apply here: babrahaminstitute.livevacanc⦠#academicjobs @IHEC_Epigenomes
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10 Feb 2021
Did you ever wonder if there are any biomarker for brain injuries π§ ? Read the nice commentary from the talented @rust_ruslan to learn more!ππ¬π
10 Feb 2021
Many of us have heard about #biomarker - But why are they so tremendously important to manage a brain injury? Have a look at my recent commentary in @_JCBFM about the recent developments of promising new blood biomarker for stroke. 1/6 ππ§ π€
journals.sagepub.com/doi/fulβ¦
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Tim Lohoff retweeted
2 Feb 2021
Really excited to share our paper on @NatureGenet about the impact of mitochondrial metabolism on nuclear DNA methylation. Thanks to @ERC_Research ,@ArmeniseHarvard, @Telethonitalia, @UniPadova for the amazing support.
go.nature.com/39CU7Ur
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Tim Lohoff retweeted
27 Jan 2021
Check out our latest work of DNA seqFISH now published @nature nature.com/articles/s41586-0β¦
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You wanna build muscles? πͺπΌ
At least in vitro we know how π Check out our latest paper @eLife investigating forces during muscle development!
Huge shout out to @GilbertLab and @JoergEnderlein for making it so beautiful!
elifesciences.org/articles/6β¦
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Tim Lohoff retweeted
19 Jan 2021
E8.5 seqFISH data from @Tim_Lohoff/@shazanfar/@LongCai_Lab is on MouseGastrulationData devel now! Count matrices, annotation, spot locations, cell segmentation masks, imputed Tx-wide counts - the whole shebang. Give it a go for methods work or dev bio! bioconductor.org/packages/deβ¦
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18 Jan 2021
Congratulations @Diljeet_Gill @aledjohnparry and all other authors π₯³. One of the most exciting projects from the lab showing that transient reprogramming leads to rejuvenation of human fibroblast! Check out the preprint π:
Preprint alert! π By expressing the Yamanaka factors until the maturation phase of iPSC reprogramming and then withdrawing them, we were able to rejuvenate human cells (many features suggest by ~30 years!) whilst retaining their initial cell identity.
biorxiv.org/content/10.1101/β¦
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