Urologist & Director of GU Oncology, Peter MacCallum Cancer Centre | Professor, University of Melbourne | Podcasting at GU Cast. Views my own. RT = endorsement
Joined March 2011
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Declan Murphy retweeted
Great to see #PRIMARY2 paper in @TheLancetOncol. ICYMI our GU Cast here @ButeauJames @drlouiseemmett @DrDanielMoon @declangmurphy youtu.be/jvWis1RcXz0?si=67Dj…
Jun 10
Thrilled to share #PRIMARY2 Trial Results. This is the first randomised trial to show that adding [⁶⁸Ga]Ga-PSMA-11 PET-CT to MRI can safely halve the number of men needing a prostate biopsy.
Hot off the press in @TheLancetOncol 🎉
In 660 men across Australian sites with PI-RADS 2-3 but high clinical risk, PSMA-PET:
- Avoided biopsy in nearly half (49%)
- Was non-inferior for detecting clinically significant cancer (12% vs 16%)
- Halved the overdiagnosis of insignificant cancer (32% to 14%)
Fewer biopsies, less overdiagnosis, whilst not missing clinically significant prostate cancer: a real step forward for the diagnostic pathway.
Enormous congratulations to @ButeauJames @PeterMacCC , who led this as the centrepiece of his PhD and presented it as a plenary at #EAU26 in London. And to my brilliant co-lead @drlouiseemmett - this was a true partnership across our two centres.
Thank you to the UROLOGISTS @DrDanielMoon @declangmurphy (& many others), nuclear medicine physicians, technologists, radiopharmaceutical scientists across every site, and to @AnnetteVDHeyden and the @pros_tic who held it all together.
We are grateful to our funders: @PCF_Science, @nhmrc, St Vincent's Curran Foundation, Peter MacCallum Cancer Foundation, and @ANZUPtrials
Most of all, thank you to the 660 men who took part.
Open Access article: thelancet.com/journals/lanon…
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Declan Murphy retweeted
Jun 8
@pros_tic #26 is approaching!! Register NOW before places run out. There are still sponsorship opportunities available as well. Don't miss the premier THERANOSTICS meeting of 2026: Sep 3-5 in Melbourne spring. prostic26.org
Abstract submission extended. @PCF_Science @gu_onc
Invited speakers include @CaPsurvivorship @MatthiasEiber @Albert0Briganti @drlouiseemmett @AmarUjalaNews @yao_zhu_sh @declangmurphy & many many more
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Declan Murphy retweeted
Jun 6
@ASTRO_org @devos_gaetan @TheGiesen ADT control was deliberate: isolates apalutamide effect AND enables the pathological co-primary endpoint (pCR/MRD) — impossible without it. OS is immature, but disease-specific survival already trends favourably: 26 vs 42 cancer deaths. /1
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ICYMI - PROTEUS Discussion at #ASCO26. A new journey for high risk prostate cancer patients. Perioperative hormone therapy, space exploration, what is progress, and a bit of Greek mythology throw in @adamkibel_uro youtu.be/7n7PFmpAlVY?si=FeG7…
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I love Aboriginal art. I wore this tie for my @ASCO Plenary this week to celebrate that. Kulyakartu Ngurra tie by deceased Martu man, Wokka Taylor. Had compliments from the big crowd #asco26. Links in thread if you want to learn more or buy similar! #ascofashion @RenuEapen
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More about Wokka Taylor oneoftwelve.com/artists__tra…
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One of Twelve online store oneoftwelve.com/
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Declan Murphy retweeted
May 31
ASTRO notes the PROTEUS trial presentation at #ASCO2026. The results contribute to an evolving evidence base for high-risk prostate cancer — one that includes long-term data supporting radiotherapy with ADT. Patients should discuss all options with their care team. #ProstateCancer @NehaVapiwala @AmarUKishan @RTAnswers_org @SpeedofLightFdn
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Phase 3 PROTEUS study, presented at #ASCO26, found a potential new targeted treatment (apalutamide ADT) option for ppl w local High⬆️ risk #ProstateCancer. @WilliamOhMD weighs in.
Read the abstract: bit.ly/3Rz7vl2
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#ASCODailyNews covers the #ASCO26 Plenary Session: Phase 3 PROTEUS study met both dual primary endpoints, suggesting perioperative apalutamide ADT could redefine treatment of high-risk #prostatecancer.
Read more: bit.ly/4nVfuop
@DanaFarber @declangmurphy @PeterMacCC
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Declan Murphy retweeted
The most important paper of #ASCO26 just dropped in Nature Med! Or any other @asco or @myESMO meetings to be honest. When you hear someone present “the toxicities were acceptable”, please respond “downplaying toxicities is not acceptable”. Thank you @NatureMedicine for publishing this piece.
nature.com/articles/s41591-0…
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Declan Murphy retweeted
May 31
Another provocative Q from @declangmurphy: does RP explain the diff across these parallel trials? #PROTEUS #ASCO26
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Is there a name for that condition where people are incontinent of thoughts and words on Twitter?!! You see it on other platforms. Must be some meds or some sort of sphincter you can put on the post button. Or just focus on day job. THANK YOU FOR YOUR ATTENTION TO THIS MATTER 😀
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Declan Murphy retweeted
May 31
Only @declangmurphy can give a cancer surgery commentary kicked off with astronomy and mythology slides 😁#PROTEUS #ASCO26
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Declan Murphy retweeted
May 31
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Declan Murphy retweeted
#PROTEUS presentation excellently discussed by @declangmurphy focusing on the right aspects to be discussed in early stage #ProstateCancer studies #Enzarad #Proteus next steps to be implemented - including the development of #FFCD Freedom From Clinical Detriment as an endpoint to prove true benefit for patients
Thank you for generating visibility for this important upcoming endpoint work @declangmurphy
@ChrisSweens1 #ASCO2026 @OncoDailyGU @oncodaily @urotoday
Finally #PROTEUS (#MyBaby) presents results. Significantly improved outcomes reported by Mary-Ellen Taplin for #neoadjuvant/perioperative treatment with #Apalutamide prior to #RadicalProstatectomy
PCR/MFS ( based on #PSMAPET), Time to subsequent treatment, to distant mets significantly improved
#ProstateCancer #ASCO2026
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Declan Murphy retweeted
🗣️ ASCO discussant @declangmurphy:
🎯 Control arm matters
⏳ OS still immature
📊 MFS by composite imaging ≠ OS
🌍 Real-world toxicity, recovery, low post-op RT rates matter
👉 Not "treat everyone more." Better-selected treatment.
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Declan Murphy retweeted
Jun 1
🎯 Excellent discussion @ASCO @declangmurphy as usual!! @gu_onc !! @ASCOPres It’s practice changing? Yes or no we have a new opportunity for our pts! We need more information to better define a HRPCa➡️ baseline PET-PSMA, biomarkers, bpMRI! @DrChoueiri @GuardConsortium
May 31
An @OncoAlert 🚨 @gu_onc Exclusive for #ASCO26
Straight from the podium to your screen, we are proud to introduce @declangmurphy 🇦🇺Discussing PROTEUS
Perioperative Apalutamide in High-Risk Localized Prostate Cancer From #ASCO26 to NEJM buff.ly/BAj6DlM
A phase 3 trial randomized 2,109 patients with newly diagnosed high-risk localized or locally advanced #ProstateCancer to perioperative ADT plus apalutamide💊 or placebo before and after radical prostatectomy
@marty_gleave
@EfstathiouEleni
@DrPaulNguyen
@Albert0Briganti
@ProfHadaschik
@ashleyrossmdphd
@adamkibel_uro
@montypal @crisbergerot @DrDanielHeng @apolo_andrea @DrChoueiri @PGrivasMDPhD @TiansterZhang @HHammersMD @ravikanesvaran @neerajaiims @amerseburger @sonpavde @drenriquegrande @scserendipity1 @Silke_Gillessen
@EfstathiouEleni @tompowles1 @BraunMDPhD @nataliagandur @cdanicas @brian_rini @AOmlin
@yekeduz_emre @DrYukselUrun @scocmem @AmandaNizamMD
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Declan Murphy retweeted
Enjoyed the wonderful talk on “Radioligand Revolutions” in #prostatecancer by @RenuEapen @ASCO #ASCO26 👉New Isotopes, New Targets, and Upcoming Combination Therapy👇Congratulations. @gu_onc @declangmurphy @urotoday @PCF_Science @OncoAlert @OpenMedicineHQ
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