Does the immune system protect against cancer? Today our study on HLA immunogenetics and lung cancer risk has been published in @ScienceMagazine led by @chirag_msk @AnniinaTervi @MiriamSaffern @EricWil39327976 @HannaMOllila @rsamstein science.org/doi/10.1126/scie…

📣 New VHIO-@CaixaResearch Scientific Seminar‼️ 🔹 Learning the language of tumor evolution and immune recognition 👩‍🔬 @diegochowell - @IcahnMountSinai 🎤 Host: Dr. Fran Martínez 🗓 Friday, 15th May at 12h Register at 👉 scientific.seminars@vhio.net

Thrilled to see a new paper led by the outstanding @Brown_lab1, now out in Nature Biotechnology. We provide mechanistic insights into how mRNA vaccines work. challenging key assumptions and offering new ways to control vaccine activity. (1/3) Read here: nature.com/articles/s41587-0…

Thrilled to share our new @NatureGenet paper! We mapped human skin at single-cell spatial resolution and found that anatomy is encoded in cell states and neighborhoods, led by PhD student @paularstrpo. Link: nature.com/articles/s41588-0… 1/9

New paper in Cancer Discovery @CD_AACR reports on SPP1⁺ macrophage–IL-6–CRP inflammatory axis linked to resistance to checkpoint blockade in #bladdercancer. pubmed.ncbi.nlm.nih.gov/4174… mountsinai.org/about/newsroo… @michelle_a_tran @diegochowell @BhardwajLab @IcahnMountSinai

Our new paper is online in Cancer Discovery @CD_AACR! Excited to share the final first-author paper of my PhD. We identify an SPP1⁺ macrophage–IL-6–CRP inflammatory axis linked to resistance to checkpoint blockade in bladder cancer. doi.org/10.1158/2159-8290.CD…

Now online in @CD_AACR: A Tumor-Promoting Inflammatory SPP1 Macrophage—IL-6—CRP Axis Drives Immune Dysfunction in Bladder Cancer - by @michelle_a_tran, Byuri Angela Cho, @sudeh9, Seong-Keun Yoo, @diegochowell, Matthew Galsky, @BhardwajLab, & colleagues @TischCancer @SinaiImmunol

Our new Nature study, lead by @yuexing identifies a brief early-life window when skin dendritic cells sense common allergens and trigger inflammation right in the skin without migrating to lymph nodes. We define this in-situ activation state as peripheral immune inducer (pii)DC, and show it emerges because of a still-maturing HPA axis and low systemic glucocorticoids. #Naiklab 👉Key takeaways: 1. Early-life immunity plays by different rules. During this window, innate responses to allergens in skin are heighted. 2. Hormones shape immunity in real time. Developmental neuroendocrine states profoundly tune how the immune system reacts, and can set the stage for inflammatory disease. Thanks our incredible collaborators @niroanandalab @EmmaGuttman @kamalkhanna @Teresalu @Amandalund and others. Our funders @NIAIDNews @NIH @DermalCell @SinaiImmunol @MSHSDerm nature.com/articles/s41586-0…

STmut is now working on Visium HD data! Infer copy number from spatial transcriptomics data at unparalleled accuracy and resolution

Excited to share our review highlighting how loss/dysregulation of resident tissue macrophages drives tissue damage in aging. Together with enhanced myelopoiesis & reduced lymphopoiesis, this creates a vicious cycle we aim to target to promote healthier aging. @SinaiImmunol

🚨Today in @CellCellPress, we show that RNA splicing factor mutations in myeloid cancers generate splicing-derived public neoantigens targetable by #TCR tx. Amazing collaboration co-led by @AbdelWahablab, @bradleybio, and @KlebanoffLab. #Tcellpower cell.com/cell/fulltext/S0092…

Excited to share our paper out today in @CellPressNews discovering RNA mis-splicing derived neoantigens & their cognate T cell receptors (TCRs) as well as characterization of endogenous neoantigen T cells in leukemia patients. authors.elsevier.com/sd/arti…

cancer.gov/news-events/cance… To build and test SCORPIO, @diegochowell and colleagues used data from nearly 10,000 people who had been treated with one or a combination of immune checkpoint inhibitors at @MountSinaiNYC and @MSKCancerCenter.

Who would benefit from checkpoint inhibitor immunotherapy for cancer? A machine learning model based on routine lab tests and basic clinical data outperformed FDA approved biomarkers (such as PD-L1) nature.com/articles/s41591-0… @NatureMedicine from nearly 10,000 patients @MSKCancerCenter and @MountSinaiNYC

What unique insights can modeling approaches capture about the immune system? cell.com/cell-systems/fullte… Voices @CellSystemsCP

To find out how genetic immune escape alterations interact with environmental factors in cancer, and understanding this relationship informs approaches to early detection and therapy, check out this REVIEW in @trendscancer by @diegochowell & @fran_mj88 >>> cell.com/trends/cancer/fullt…

For your reading pleasure…the latest from the lab. rdcu.be/dVyiU. First large scale neoantigen reactivity landscape in patients treated with anti-pd1.