Do all older pts with MCL need 1L BR BTKi? #lymsm - 755 pts: all 1L BR - mEFS after 1L BR 34 mo - mEFS2 (1L BR➡️2L BTKi) 65 mo - 5-yr OS 58%, 7-yr OS: 51% - 76% received BTKi in 2L, mEFS after 2L BTKi 10 mos - worse outcomes:⬆️sMIPI, Ki67 ≥50%, blastoid/pleomorphic, TP53mut, complex karyotype Sequencing BR then BTKi appropriate in MCL, especially if no high-risk features. #lymsm pubmed.ncbi.nlm.nih.gov/4203…

🔥NeoPancOne🇨🇦 ➡️mFFX in resectable PDAC ➡️exploring GATA6&subtypes ➡️mEFS &OS 16.3 &34.2mths ➡️1yr EFS 90% in GATA6 hi vs 50% lo ➡️1yr OS classical 95% vs.57% basal-like ⭐️Time to subtype upfront in all PDAC recognising plasticity @OncoAlert #ASCO25 @OICR_news @pmcancercentre

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What if your data no longer begged for permission—to be moved, accessed, or kept safe? With #DecentralizedStorage, you're not just the owner—you're the infrastructure. #DataSovereignty #MEFS

Airspace to the army and marines, and is trying to figure out whether they want to even have a unified lead command for UAS operations or whether they want to divy it up between ACC AFSOC and AFCEC but have yet to even develop METs/MEFs and JMETLs for UAS operations…

#オタギャル　10話 コスプレ喫茶 メイド服姿で接客する伊地知の姿、瀬尾がアース様を扮した状態で接客する姿、どちらも映える姿に その後、天音が大帝ヴァンプのコスプレをして登場 この姿もまた、捨てがたい

The BOSS knows how to reward hard work! Make everyone feel special, MEFS!

Can your agency deliver Mission Essential Functions when systems are degraded? Join @FedInsider on 6/10 to explore resilience strategies that move agencies from “MEFs documented” to “MEFs deliverable” w/ @USDA & @OrbusSoftware. tinyurl.com/4237ue77 @PegHosky @Carahsoft @cpsgwu

Mefs will do that. 🤣

Yeah. I can imagine how that would go... "Hey luv. I've just been watching these shitty arsed mefs from America, talking about their bathroom habits. How dya fancy only flushing the bog once every Friday and we all wipe our arses with the same sponge on a stick? The wife........

Boat mefs?

📄 Full MARADMIN text: Released 09 JUN 2026 at 19:16 UTC (Zulu) / MARADMIN 271/26 Subject: Fy24 special technical operations planner selection panel results 1. Per reference (c), the Special Technical Operations Free MOS (8016) Selection Panel convened from 01-04 Jun 2026. The panel reviewed 19 applications and selected 19 Marines. A memorandum with the list of Marines selected is posted on the SIPRNET SharePoint site: https:(slash)(slash)intelshare.intelink.sgov.gov…. A copy of the memorandum will be distributed to the STO Chiefs at all MEFs and MARFORs. 2. Marines are instructed to submit this memorandum via EPAR to their local administration center, which will enter the appropriate entry in their Official Military Personnel File to reflect the FMOS. 3. Commanders are encouraged to utilize Marines with the 8016 FMOS in accordance with reference (a) to provide material contribution to service STO efforts through exercise support, wargaming, and crisis and contingency operations planning. 4. Questions concerning the Special Technical Operations Planner FMOS can be directed to the POCs given above. 5. Release authorized by BGen Daniel B. Taylor, Director, Strategy and Plans Division, Plans, Policies and Operations, Headquarters U.S. Marine Corps. REF/A/DOC/MCO S003120.2A/20DEC2022// REF/B/NAVMC/1200.1M/02MAR2026// REF/C/MARADMIN/173.26/14APR2026// REF/D/DIR PL LTR/1000/17AUG2015// POC1/LIVINGSTON, ALEXANDER J./MAJ/CMC PPO PL WASHINGTON DC/DSN 222-4331/703-692-4331/ALEXANDER.LIVINGSTON@USMC.MIL.// POC2/COCHRANE, BURKE/CIV/CMC PPO PL WASHINGTON DC/DSN 224-0285/703-695-0187/BURKETT.COCHRANE@USMC.MIL.// Source: marines.mil/News/Messages/Me… 🤖 This text was reformatted for readability.

🧬 Neoadj GOLP in resectable high-risk iCCA GemOx toripalimab lenvatinib → surgery (Ph II–III) 📈 mEFS 18.0 vs 8.7 mo (P<0.001) 📊 24-mo OS 79% vs 61% (HR 0.43) ⚠️ G3–4 AEs 28% in neoadj phase 👉 1st RCT supporting neoadj tx in high-risk iCCA 🔗 doi.org/10.1056/NEJMoa250843… @OncoAlert

He's just feeling a bit groggy after being poked and prodded yesterday and the mefs are making him feel a bit scrappy, but hes still eating so that's good. Thank you for asking 💜🙏🏽

Can your agency deliver Mission Essential Functions when systems are degraded? Join @FedInsider on 6/10 to explore resilience strategies that move agencies from “MEFs documented” to “MEFs deliverable” w/ @USDA & @OrbusSoftware. tinyurl.com/4237ue77 @PegHosky @Carahsoft @cpsgwu

The #OncoAlertTopTweet 🚨Day Three #ASCO26 Post by @OncoAlert Faculty @HHorinouchi 🇯🇵 🔥LIBRETTO-432: Event-Free Survival with Adjuvant Selpercatinib in Stage IB-IIIA RET Fusion-Positive NSCLC ✅Stage II-IIIA EFS HR 0.172 (95%CI 0.058-0.509; p=0.0003) ✅2-yr EFS 91.5% vs 61.1%; mEFS NR vs 31.8mo ✅No deaths on study treatment Ping: OncoAlert ❤️Pulse @DrChoueiri 🇺🇸 @hoperugo 🇺🇸 @matteolambe 🇮🇹 @TiansterZhang 🇺🇸 @CathyEngMD 🇺🇸 @stolaney1 🇺🇸 @montypal 🇺🇸 @tompowles1 🇬🇧 @brian_rini 🇺🇸 @cdanicas 🇪🇸 @NiuSanford 🇺🇸 @amerseburger 🇩🇪 @GlopesMd 🇺🇸 @Icro_Meattini 🇮🇹 @PGrivasMDPhD 🇺🇸 @DrYukselUrun 🇹🇷 @nataliagandur 🇦🇷 @ElisaAgostinett 🇧🇪 @HHorinouchi 🇯🇵 @realbowtiedoc 🇺🇸 @to_be_elizabeth 🇮🇹 @UOzkerim 🇹🇷 @p_ciracimd 🇮🇹 @DrVilmaPBarcia 🇪🇸 @DraMartinezLago 🇪🇸 @DrMirallas 🇺🇸 @GaiaGriguolo 🇮🇹 @MarioBalsaMD 🇪🇸 @scocmem 🇬🇧 @AmandaNizamMD 🇺🇸 & @weoncologists 🇺🇸

🆙 #ASCO26 #LCSM Plenary Session 🔥LIBRETTO-432: Event-Free Survival with Adjuvant Selpercatinib in Stage IB-IIIA RET Fusion-Positive NSCLC ✅Stage II-IIIA EFS HR 0.172 (95%CI 0.058-0.509; p=0.0003) ✅2-yr EFS 91.5% vs 61.1%; mEFS NR vs 31.8mo ✅No deaths on study treatment 🎙️Dr. Jonathan W. Goldman 🔢LBA3 ☑️NCT04819100 🔗 asco.org/abstracts-presentat… @OncoAlert @Larvol @ASCO @IASLC @RetRenegades

🔥BREAKING‼️ @NEJM 🆙 🔥LIBRETTO-432: Adjuvant Selpercatinib vs Placebo in Stage IB-IIIA RET Fusion NSCLC (N=151) ✅Stage II-IIIA EFS HR 0.172 (95%CI 0.058-0.509; p=0.0003) ✅2-yr EFS 91.5% vs 61.1%; mEFS NR vs 31.8mo ✅No deaths on study treatment 🎙️ Dr. Jonathan W. Goldman Dr. Yi-Long Wu 🔜 #ASCO26 #LCMS, Plenary @OncoAlert @Larvol @ASCO @IASLC @RetRenegades