Cost-effectiveness of immediate versus postponed interventionfor infected necrotizing pancreatitis: planned secondaryanalysis of the POINTER trial
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doi.org/10.1093/bjs/znaf071
In patients with infected necrotizing pancreatitis, immediate catheter drainage does not offer a cost-effective or clinically superior alternative to postponed drainage
Findings from the POINTER trial-based economic analysis show:
💶 Immediate drainage costs ~€10K more per patient (healthcare & societal).
❌ No significant improvement in complication severity (CCI) or quality of life (QALYs).
💸 Low probability of cost-effectiveness even at high willingness-to-pay thresholds.
Work by Michiel F G Francken , Lotte Boxhoorn , Sven M van Dijk , Janneke van Grinsven , Robert C Verdonk , Marja A Boermeester , Thomas L Bollen , Stefan A W Bouwense , Marco J Bruno , Vincent C Cappendijk , Peter van Duijvendijk , Casper H J van Eijck , Paul Fockens , Harry van Goor , Muhammed Hadithi , Nora D L Hallensleben , Jan Willem Haveman , Maarten A J M Jacobs , Jeroen M Jansen , Marnix P M Kop , Krijn P van Lienden , Eric R Manusama , J Sven D Mieog , I Quintus Molenaar , Vincent B Nieuwenhuijs , Alexander C Poen , Jan-Werner Poley , Marcel van de Poll , Rutger Quispel , Tessa E H Römkens , Matthijs P Schwartz , Tom C Seerden , Martijn W J Stommel , Jan Willem A Straathof , Hester C Timmerhuis , Niels G Venneman , Rogier P Voermans , Wim van de Vrie , Hjalmar C van Santvoort , Marc G Besselink , Marcel G W Dijkgraaf on behalf of the Dutch Pancreatitis Study Group
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